Coxph analysis Adi C1A-C1B

Result

Analysis details

Demographic information

load("/mnt/data/lab/gmt_data/data_brain/gmt_analysis/compare_mouse_signatures_with_human/annotation_gbm_lgg_July2021.RData")
colnames(ann3)[1]<-"Samples"

annotation_mut<-ann3[ann3$type%in%"LGG" & (ann3$IDH1==1 | ann3$IDH2==1)  & (ann3$TP53==1 & ann3$ATRX==1),]
print(paste("The number of samples LGG with IDH*, TP53, ATRX is:",nrow(annotation_mut)))

## [1] "The number of samples LGG with IDH*, TP53, ATRX is: 164"

annotation_only_idh<-ann3[ann3$type%in%"LGG" & (ann3$IDH1==1 | ann3$IDH2==1),]
print(paste("The number of samples LGG with IDH* is:",nrow(annotation_only_idh)))

## [1] "The number of samples LGG with IDH* is: 411"

annotation_gbm_lgg<-ann3
print(paste("The number of samples LGG  and GBM:",nrow(annotation_gbm_lgg)))

## [1] "The number of samples LGG  and GBM: 794"

annotation_idh_codel_nocodel<-ann3[ann3$type%in%"LGG" & (ann3$IDH_codel_subtype=="IDHmut-codel" | ann3$IDH_codel_subtype=="IDHmut-non-codel"),]
print(paste("The number of samples LGG IDHmut-codel and IDHmut-non-codel is:",nrow(annotation_idh_codel_nocodel)))

## [1] "The number of samples LGG IDHmut-codel and IDHmut-non-codel is: 414"

annotation_idh_codel<-ann3[ann3$type%in%"LGG" & (ann3$IDH_codel_subtype=="IDHmut-codel"),]
print(paste("The number of samples LGG with IDHmut-codel is:",nrow(annotation_idh_codel)))

## [1] "The number of samples LGG with IDHmut-codel is: 169"

annotation_idh_nocodel<-ann3[ann3$type%in%"LGG" & (ann3$IDH_codel_subtype=="IDHmut-non-codel"),]
print(paste("The number of samples LGG with IDHmut-non-codel is:",nrow(annotation_idh_nocodel)))

## [1] "The number of samples LGG with IDHmut-non-codel is: 245"

annotation_gbm_only<-ann3[ann3$type%in%"GBM",]
print(paste("The number of samples GBM is:",nrow(annotation_gbm_only)))

## [1] "The number of samples GBM is: 285"

Analysis

• Step1: Select the genes with cox proportional hazard models in IDH_NOCODEL (logRank p-value < 0.05)
• Step2: Select a group of samples (e.g. IDH*/TP53/ATRX)
• Step3: Consider different tresholds of logRank 0.01,0.001,0.05
• Step4: Select the genes according with Step3
• Step5: Compute the gsva scores (default parameters) using 1) up and down genes 2) only up 3) only down
• Step6: If there is a sufficent number of genes, compute the difference between the scores computed using the up-regulated genes and down-regulated genes (up-down) (C1A is the numerator). This whati I call “global_score”.
• Step7: The stratification of the samples is perfomed using 0 as cut-off value to distinguish (MCP). The classification are stored in a column (“status_C1AC1B”).
• Step8: Plot the Kaplan Meier curve with the overall survival as outcome
• Step9: Use surv_cutpoint and column global_score to define automatically a cut-point for the groups

FAQ report

• The order of the rows is based on the logRank cut-off (0.05, 0.01, 0.01)
• First column: overall survival using manual cut-point (0) see Step7
• Second-third columns: results surv_cutpoint
• Second-third columns: results surv_cutpoint
• Table-genes: results of cox proportional hazard model with IDH_NOCODEL samples (logRank p-value < 0.05). Use column logRank to select the genes.

IDH TRIPLE MUT

UP and DOWN

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UP

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DOWN

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Table genes

	Variable	Term	Beta	StandardError	Z	P	LRT	Wald	LogRank	HR	HRlower	HRupper	mm	status
47	GPR139	GPR139	2.9954716	0.5459944	5.486268	0.0000000	0.0000008	0.0000000	0.0000000	1.999479e+01	6.8574946	5.829993e+01	Gpr139	up
11	BVES	BVES	0.7842063	0.1424517	5.505070	0.0000000	0.0000025	0.0000000	0.0000001	2.190667e+00	1.6569958	2.896220e+00	Bves	up
22	CHIC2	CHIC2	1.1744777	0.2267115	5.180495	0.0000002	0.0000079	0.0000002	0.0000002	3.236452e+00	2.0753531	5.047152e+00	Chic2	down
62	LRRK2	LRRK2	0.6724442	0.1341983	5.010825	0.0000005	0.0000059	0.0000005	0.0000002	1.959020e+00	1.5059447	2.548406e+00	Lrrk2	up
21	CEP135	CEP135	1.1901584	0.2479228	4.800520	0.0000016	0.0000491	0.0000016	0.0000014	3.287602e+00	2.0223064	5.344554e+00	Cep135	down
133	ZBTB8B	ZBTB8B	1.1045218	0.2349319	4.701455	0.0000026	0.0000192	0.0000026	0.0000022	3.017781e+00	1.9042034	4.782579e+00	Zbtb8b	up
86	PI4K2B	PI4K2B	1.0371524	0.2498474	4.151143	0.0000331	0.0015532	0.0000331	0.0000217	2.821172e+00	1.7288568	4.603626e+00	Pi4k2b	down
102	SERINC2	SERINC2	0.6263722	0.1610620	3.889012	0.0001007	0.0002453	0.0001007	0.0000827	1.870811e+00	1.3643749	2.565230e+00	Serinc2	up
104	SH3GL2	SH3GL2	-0.7907620	0.2005988	-3.942008	0.0000808	0.0000695	0.0000808	0.0001115	4.534991e-01	0.3060740	6.719337e-01	Sh3gl2	up
15	CCDC87	CCDC87	-0.7788043	0.2036870	-3.823535	0.0001316	0.0001516	0.0001316	0.0001223	4.589545e-01	0.3078867	6.841452e-01	Ccdc87	up
80	PCDHGA3	PCDHGA3	0.6336887	0.1854916	3.416266	0.0006349	0.0047731	0.0006349	0.0001990	1.884549e+00	1.3101371	2.710805e+00	Pcdhga3	up
101	SEPSECS	SEPSECS	1.0745060	0.2684215	4.003055	0.0000625	0.0004790	0.0000625	0.0002610	2.928546e+00	1.7304985	4.956017e+00	Sepsecs	down
78	PAX5	PAX5	4.3732708	1.3013911	3.360458	0.0007781	0.0111408	0.0007781	0.0002911	7.930259e+01	6.1878707	1.016327e+03	Pax5	down
54	KCNG1	KCNG1	-0.5347163	0.1540201	-3.471731	0.0005171	0.0001938	0.0005171	0.0004520	5.858355e-01	0.4331851	7.922784e-01	Kcng1	up
85	PHKG1	PHKG1	-0.3998301	0.1165522	-3.430480	0.0006025	0.0009269	0.0006025	0.0004617	6.704339e-01	0.5335149	8.424913e-01	Phkg1	up
50	HHIP	HHIP	0.5367070	0.1575686	3.406179	0.0006588	0.0014311	0.0006588	0.0005304	1.710365e+00	1.2559323	2.329225e+00	Hhip	up
36	EFCAB6	EFCAB6	-7.0065194	2.0604116	-3.400543	0.0006725	0.0002490	0.0006725	0.0005886	9.060000e-04	0.0000160	5.139640e-02	Efcab6	up
68	METTL11B	METTL11B	2.6216611	0.8373169	3.131026	0.0017420	0.0097680	0.0017420	0.0007621	1.375856e+01	2.6659224	7.100655e+01	Mettl11b	up
89	PLCXD1	PLCXD1	0.6979770	0.2051305	3.402601	0.0006675	0.0009493	0.0006675	0.0007977	2.009683e+00	1.3443743	3.004242e+00	Plcxd1	up
25	CLEC18A	CLEC18A	2.0090652	0.6175386	3.253344	0.0011406	0.0037224	0.0011406	0.0009366	7.456344e+00	2.2226761	2.501357e+01	Clec18a	up
82	PCDHGA8	PCDHGA8	4.5064285	1.4663795	3.073167	0.0021180	0.0114419	0.0021180	0.0016940	9.059767e+01	5.1160230	1.604359e+03	Pcdhga8	up
79	PCDH7	PCDH7	-0.7147787	0.2368258	-3.018163	0.0025431	0.0019136	0.0025431	0.0024481	4.893004e-01	0.3076020	7.783268e-01	Pcdh7	up
17	CCNB2	CCNB2	0.3221457	0.1089420	2.957039	0.0031061	0.0046368	0.0031061	0.0027830	1.380086e+00	1.1147424	1.708589e+00	Ccnb2	down
1	ABCA8	ABCA8	0.4256288	0.1413422	3.011336	0.0026010	0.0059862	0.0026010	0.0030725	1.530552e+00	1.1602125	2.019105e+00	Abca8b	up
43	GDF10	GDF10	-0.3061819	0.1055962	-2.899555	0.0037369	0.0022250	0.0037369	0.0032660	7.362527e-01	0.5986090	9.055460e-01	Gdf10	up
44	GJA1	GJA1	-0.4050831	0.1380017	-2.935349	0.0033317	0.0035724	0.0033317	0.0034714	6.669214e-01	0.5088706	8.740613e-01	Gja1	up
29	CRTAC1	CRTAC1	-0.5539521	0.1912721	-2.896147	0.0037778	0.0040257	0.0037778	0.0037843	5.746742e-01	0.3950123	8.360510e-01	Crtac1	up
74	NRG3	NRG3	-2.4032161	0.8375289	-2.869413	0.0041123	0.0031459	0.0041123	0.0039243	9.042670e-02	0.0175142	4.668770e-01	Nrg3	up
123	TPSAB1	TPSAB1	-0.7426437	0.2748043	-2.702446	0.0068831	0.0004653	0.0068831	0.0039419	4.758542e-01	0.2776899	8.154320e-01	Tpsb2	down
128	TUB	TUB	-0.5196510	0.1808249	-2.873780	0.0040559	0.0047320	0.0040559	0.0041056	5.947281e-01	0.4172535	8.476897e-01	Tub	up
103	SFTPC	SFTPC	0.4223342	0.1487355	2.839498	0.0045185	0.0058762	0.0045185	0.0041667	1.525518e+00	1.1397603	2.041838e+00	Sftpc	up
120	TCHH	TCHH	-0.5988549	0.2142769	-2.794771	0.0051936	0.0025865	0.0051936	0.0050215	5.494404e-01	0.3610171	8.362064e-01	Tchh	up
130	VWC2	VWC2	-0.8118496	0.2985573	-2.719242	0.0065432	0.0042834	0.0065432	0.0057806	4.440360e-01	0.2473351	7.971695e-01	Vwc2	up
27	CNGA4	CNGA4	-1.0359853	0.3821171	-2.711172	0.0067046	0.0040296	0.0067046	0.0063590	3.548765e-01	0.1678103	7.504746e-01	Cnga4	up
114	SPHKAP	SPHKAP	-0.4625777	0.1721975	-2.686321	0.0072244	0.0065275	0.0072244	0.0068047	6.296585e-01	0.4492936	8.824291e-01	Sphkap	up
46	GLT8D2	GLT8D2	-1.6440659	0.6170412	-2.664435	0.0077118	0.0045787	0.0077118	0.0071151	1.931929e-01	0.0576454	6.474670e-01	Glt8d2	up
40	FAM186B	FAM186B	2.7648858	1.0270985	2.691938	0.0071038	0.0102688	0.0071038	0.0071928	1.587723e+01	2.1208349	1.188618e+02	Fam186b	up
5	ADCY2	ADCY2	-0.5091532	0.1915128	-2.658586	0.0078469	0.0086014	0.0078469	0.0075234	6.010043e-01	0.4129159	8.747693e-01	Adcy2	up
87	PLA2G4E	PLA2G4E	19.0823473	7.2463960	2.633357	0.0084545	0.0379296	0.0084545	0.0081310	1.938019e+08	131.5875091	2.854313e+14	Pla2g4e	up
96	RAB42	RAB42	0.5038644	0.1915025	2.631111	0.0085106	0.0086515	0.0085106	0.0084776	1.655105e+00	1.1371513	2.408978e+00	Rab42	up
73	NR3C2	NR3C2	-1.1889369	0.4523989	-2.628072	0.0085870	0.0066070	0.0085870	0.0085969	3.045449e-01	0.1254783	7.391523e-01	Nr3c2	up
60	LRRC18	LRRC18	0.8248612	0.3172093	2.600369	0.0093124	0.0202333	0.0093124	0.0094480	2.281564e+00	1.2252469	4.248560e+00	Lrrc18	up
66	MAP6D1	MAP6D1	0.3520670	0.1365555	2.578198	0.0099317	0.0104100	0.0099317	0.0094586	1.422004e+00	1.0880893	1.858390e+00	Map6d1	up
69	MGAT4C	MGAT4C	-1.3821722	0.5241332	-2.637063	0.0083627	0.0040005	0.0083627	0.0095399	2.510327e-01	0.0898643	7.012506e-01	Mgat4c	up
106	SLAIN2	SLAIN2	0.8455718	0.3292619	2.568083	0.0102263	0.0111327	0.0102263	0.0096223	2.329309e+00	1.2216841	4.441149e+00	Slain2	down
113	SPAG17	SPAG17	10.0872014	4.2371258	2.380671	0.0172812	0.0574988	0.0172812	0.0110288	2.403344e+04	5.9452191	9.715474e+07	Spag17	up
37	EFEMP1	EFEMP1	-0.2914440	0.1149583	-2.535214	0.0112379	0.0122232	0.0112379	0.0111204	7.471839e-01	0.5964510	9.360093e-01	Efemp1	up
12	CACNA2D2	CACNA2D2	-0.8043295	0.3205444	-2.509261	0.0120984	0.0098839	0.0120984	0.0118147	4.473878e-01	0.2386911	8.385559e-01	Cacna2d2	up
55	KLF14	KLF14	1.6071670	0.6370812	2.522703	0.0116457	0.0346226	0.0116457	0.0119965	4.988658e+00	1.4311964	1.738875e+01	Klf14	up
127	TTLL7	TTLL7	0.4510948	0.1808449	2.494374	0.0126179	0.0140847	0.0126179	0.0121624	1.570030e+00	1.1014697	2.237914e+00	Ttll7	up
28	CPA3	CPA3	-2.6676371	1.2839007	-2.077760	0.0377315	0.0010779	0.0377315	0.0122039	6.941610e-02	0.0056053	8.596431e-01	Cpa3	down
94	PRIMA1	PRIMA1	0.6222890	0.2488279	2.500881	0.0123885	0.0134312	0.0123885	0.0122378	1.863188e+00	1.1440737	3.034306e+00	Prima1	up
110	SLC7A11	SLC7A11	-0.5173928	0.2068672	-2.501087	0.0123813	0.0111473	0.0123813	0.0128561	5.960726e-01	0.3973869	8.940974e-01	Slc7a11	up
83	PDGFRA	PDGFRA	0.3197732	0.1282574	2.493214	0.0126593	0.0114151	0.0126593	0.0129613	1.376815e+00	1.0707863	1.770307e+00	Pdgfra	down
65	MAGEE2	MAGEE2	0.2072085	0.0847911	2.443752	0.0145354	0.0121291	0.0145354	0.0129998	1.230239e+00	1.0418739	1.452659e+00	Magee2	up
26	CLMN	CLMN	0.5914685	0.2374123	2.491314	0.0127272	0.0186262	0.0127272	0.0131366	1.806639e+00	1.1344511	2.877115e+00	Clmn	up
93	PPP2R2B	PPP2R2B	-0.7571162	0.3070699	-2.465615	0.0136778	0.0122080	0.0136778	0.0135049	4.690170e-01	0.2569273	8.561837e-01	Ppp2r2b	up
70	MSR1	MSR1	0.6293928	0.2584362	2.435390	0.0148758	0.0257520	0.0148758	0.0144026	1.876471e+00	1.1307343	3.114032e+00	Msr1	down
16	CCL27	CCL27	-10.1807420	4.9394362	-2.061114	0.0392921	0.0011244	0.0392921	0.0147958	3.790000e-05	0.0000000	6.067582e-01	Ccl27a	up
111	SLITRK5	SLITRK5	-0.4852339	0.1987193	-2.441806	0.0146140	0.0166802	0.0146140	0.0148097	6.155532e-01	0.4169802	9.086900e-01	Slitrk5	up
121	TFCP2L1	TFCP2L1	0.4640884	0.1932673	2.401277	0.0163379	0.0254705	0.0163379	0.0148488	1.590564e+00	1.0890344	2.323060e+00	Tfcp2l1	up
100	SCUBE3	SCUBE3	0.5114631	0.2125001	2.406884	0.0160893	0.0256815	0.0160893	0.0148709	1.667729e+00	1.0996264	2.529333e+00	Scube3	up
134	ZCCHC3	ZCCHC3	0.8449587	0.3501292	2.413277	0.0158098	0.0144719	0.0158098	0.0157013	2.327882e+00	1.1720075	4.623719e+00	Zcchc3	up
6	AHCYL2	AHCYL2	-0.4618186	0.1916865	-2.409239	0.0159858	0.0144949	0.0159858	0.0157534	6.301366e-01	0.4327837	9.174842e-01	Ahcyl2	up
84	PELI3	PELI3	-0.5361502	0.2219673	-2.415447	0.0157159	0.0125532	0.0157159	0.0158807	5.849960e-01	0.3786292	9.038405e-01	Peli3	up
117	SYT12	SYT12	-0.3974626	0.1658915	-2.395919	0.0165787	0.0103877	0.0165787	0.0161174	6.720231e-01	0.4854864	9.302320e-01	Syt12	up
61	LRRC6	LRRC6	-1.2100537	0.5083194	-2.380499	0.0172892	0.0148202	0.0172892	0.0162693	2.981813e-01	0.1101027	8.075373e-01	Lrrc6	up
77	OSR1	OSR1	0.2144682	0.0905432	2.368683	0.0178516	0.0251440	0.0178516	0.0166777	1.239203e+00	1.0377000	1.479834e+00	Osr1	up
90	PLK5	PLK5	-0.5414021	0.2291631	-2.362518	0.0181512	0.0166165	0.0181512	0.0175387	5.819318e-01	0.3713711	9.118766e-01	Plk5	up
59	LIX1	LIX1	-0.2840070	0.1205932	-2.355083	0.0185186	0.0237242	0.0185186	0.0177018	7.527614e-01	0.5943034	9.534687e-01	Lix1	up
45	GLRA3	GLRA3	-0.6180356	0.2634646	-2.345801	0.0189862	0.0133041	0.0189862	0.0185040	5.390022e-01	0.3216097	9.033416e-01	Glra3	up
71	NIPAL3	NIPAL3	0.3068599	0.1315510	2.332631	0.0196675	0.0202769	0.0196675	0.0189767	1.359150e+00	1.0502462	1.758911e+00	Nipal3	up
75	NSUN7	NSUN7	2.8988354	1.2476243	2.323484	0.0201532	0.0274793	0.0201532	0.0194083	1.815299e+01	1.5738687	2.093765e+02	Nsun7	up
3	ABLIM3	ABLIM3	-0.4204272	0.1804536	-2.329836	0.0198148	0.0196918	0.0198148	0.0196757	6.567662e-01	0.4611141	9.354340e-01	Ablim3	up
98	RNF32	RNF32	-0.7549155	0.3244026	-2.327095	0.0199602	0.0195812	0.0199602	0.0197767	4.700503e-01	0.2488928	8.877207e-01	Rnf32	up
30	CRYBB1	CRYBB1	-0.6109657	0.2598025	-2.351655	0.0186901	0.0162412	0.0186901	0.0199216	5.428264e-01	0.3262246	9.032443e-01	Crybb1	up
122	TNNI1	TNNI1	2.8923203	1.3335905	2.168822	0.0300962	0.0799377	0.0300962	0.0199732	1.803511e+01	1.3211876	2.461915e+02	Tnni1	up
91	POPDC3	POPDC3	0.3123546	0.1361879	2.293555	0.0218161	0.0284385	0.0218161	0.0201892	1.366639e+00	1.0464789	1.784749e+00	Popdc3	up
14	CAMSAP3	CAMSAP3	-0.2662145	0.1163447	-2.288152	0.0221286	0.0232764	0.0221286	0.0215514	7.662747e-01	0.6100307	9.625368e-01	Camsap3	up
42	FZD2	FZD2	0.3875964	0.1688566	2.295418	0.0217092	0.0214499	0.0217092	0.0216465	1.473435e+00	1.0582785	2.051455e+00	Fzd2	up
135	ZCCHC4	ZCCHC4	0.7571164	0.3109674	2.434713	0.0149036	0.0324878	0.0149036	0.0221649	2.132119e+00	1.1590857	3.921998e+00	Zcchc4	down
124	TPSB2	TPSB2	-0.4678065	0.2090684	-2.237576	0.0252487	0.0102559	0.0252487	0.0225107	6.263747e-01	0.4157908	9.436123e-01	Tpsb2	down
109	SLC4A4	SLC4A4	-0.4141597	0.1824616	-2.269846	0.0232169	0.0246088	0.0232169	0.0226269	6.608954e-01	0.4621906	9.450271e-01	Slc4a4	up
52	HTR2C	HTR2C	-3.1565775	1.3995778	-2.255378	0.0241096	0.0133067	0.0241096	0.0232918	4.257120e-02	0.0027403	6.613610e-01	Htr2c	up
108	SLC35F4	SLC35F4	6.9660928	3.4145385	2.040127	0.0413377	0.1207829	0.0413377	0.0234941	1.060073e+03	1.3148471	8.546653e+05	Slc35f4	up
39	FAM111A	FAM111A	0.4931808	0.2189509	2.252472	0.0242925	0.0261799	0.0242925	0.0238429	1.637517e+00	1.0661403	2.515110e+00	Fam111a	down
118	SYT17	SYT17	-0.6691720	0.2974328	-2.249826	0.0244600	0.0230309	0.0244600	0.0240354	5.121324e-01	0.2858953	9.173975e-01	Syt17	up
95	PROK2	PROK2	1.8148931	0.8212733	2.209853	0.0271154	0.0412250	0.0271154	0.0258169	6.140420e+00	1.2278037	3.070911e+01	Prok2	up
136	ZNF519	ZNF519	0.7099944	0.3196717	2.221011	0.0263502	0.0282681	0.0263502	0.0258965	2.033980e+00	1.0870303	3.805850e+00	Zfp941	up
92	PPIL6	PPIL6	-0.8190445	0.3663250	-2.235841	0.0253622	0.0228182	0.0253622	0.0262949	4.408527e-01	0.2150191	9.038782e-01	Ppil6	up
67	MEIG1	MEIG1	-1.4153405	0.6416480	-2.205790	0.0273987	0.0165410	0.0273987	0.0263250	2.428429e-01	0.0690484	8.540773e-01	Meig1	up
41	FRY	FRY	-0.6736747	0.3074954	-2.190845	0.0284630	0.0283663	0.0284630	0.0281425	5.098316e-01	0.2790527	9.314667e-01	Fry	up
24	CHST15	CHST15	-0.4167445	0.1902333	-2.190702	0.0284734	0.0278526	0.0284734	0.0281733	6.591893e-01	0.4540287	9.570553e-01	Chst15	up
19	CDH7	CDH7	-0.6616486	0.3054743	-2.165971	0.0303134	0.0216067	0.0303134	0.0286263	5.160000e-01	0.2835499	9.390093e-01	Cdh7	up
57	KNDC1	KNDC1	-0.2969632	0.1366881	-2.172560	0.0298134	0.0279141	0.0298134	0.0293196	7.430714e-01	0.5684358	9.713588e-01	Kndc1	up
125	TTC34	TTC34	-3.7733836	1.7457180	-2.161508	0.0306561	0.0235946	0.0306561	0.0297951	2.297420e-02	0.0007504	7.033933e-01	Ttc34	up
49	HHATL	HHATL	0.2470745	0.1144943	2.157963	0.0309307	0.0303280	0.0309307	0.0308650	1.280274e+00	1.0229287	1.602363e+00	Hhatl	up
53	KCNB1	KCNB1	-0.4829054	0.2251743	-2.144585	0.0319861	0.0281475	0.0319861	0.0316609	6.169882e-01	0.3968333	9.592804e-01	Kcnb1	up
51	HS6ST2	HS6ST2	0.8537621	0.4008883	2.129676	0.0331984	0.0357143	0.0331984	0.0317125	2.348466e+00	1.0704032	5.152535e+00	Hs6st2	up
126	TTLL11	TTLL11	1.3664702	0.6377193	2.142745	0.0321335	0.0412975	0.0321335	0.0321406	3.921484e+00	1.1236286	1.368605e+01	Ttll11	up
72	NLRP6	NLRP6	0.5442128	0.2548265	2.135621	0.0327103	0.0448962	0.0327103	0.0322133	1.723251e+00	1.0457789	2.839601e+00	Nlrp6	up
64	LUZP2	LUZP2	-0.3671389	0.1727341	-2.125457	0.0335485	0.0367364	0.0335485	0.0323780	6.927134e-01	0.4937670	9.718185e-01	Luzp2	up
10	BRINP1	BRINP1	-0.3392242	0.1600891	-2.118972	0.0340928	0.0305033	0.0340928	0.0324119	7.123227e-01	0.5204856	9.748658e-01	Brinp1	up
56	KLHDC9	KLHDC9	-0.2353128	0.1106619	-2.126413	0.0334689	0.0371299	0.0334689	0.0330566	7.903236e-01	0.6362230	9.817491e-01	Klhdc9	up
88	PLCB1	PLCB1	-0.6420079	0.3024846	-2.122448	0.0338001	0.0324093	0.0338001	0.0333069	5.262348e-01	0.2908735	9.520392e-01	Plcb1	up
105	SIDT1	SIDT1	-0.4174642	0.1983770	-2.104398	0.0353437	0.0278401	0.0353437	0.0339631	6.587150e-01	0.4465178	9.717541e-01	Sidt1	up
107	SLC1A2	SLC1A2	-0.2124443	0.1003561	-2.116904	0.0342680	0.0375824	0.0342680	0.0340428	8.086053e-01	0.6642221	9.843735e-01	Slc1a2	up
38	EMID1	EMID1	-0.4502308	0.2133506	-2.110287	0.0348337	0.0338802	0.0348337	0.0343860	6.374810e-01	0.4196265	9.684374e-01	Emid1	up
13	CACNA2D4	CACNA2D4	1.0245697	0.4891258	2.094696	0.0361980	0.0427101	0.0361980	0.0350024	2.785896e+00	1.0681207	7.266237e+00	Cacna2d4	up
76	NXPH3	NXPH3	-0.3774392	0.1806948	-2.088822	0.0367238	0.0409742	0.0367238	0.0363733	6.856149e-01	0.4811412	9.769850e-01	Nxph3	up
129	UNC13B	UNC13B	-0.7827685	0.3736143	-2.095125	0.0361599	0.0336327	0.0361599	0.0369294	4.571387e-01	0.2197996	9.507559e-01	Unc13b	up
132	WNT9A	WNT9A	0.6958626	0.3367280	2.066542	0.0387773	0.0463104	0.0387773	0.0378423	2.005438e+00	1.0365397	3.880008e+00	Wnt9a	up
112	SMIM1	SMIM1	0.5206950	0.2527491	2.060126	0.0393865	0.0428917	0.0393865	0.0385225	1.683197e+00	1.0256390	2.762329e+00	Smim1	up
9	BAIAP3	BAIAP3	-0.2794113	0.1351514	-2.067396	0.0386969	0.0418946	0.0386969	0.0390339	7.562288e-01	0.5802460	9.855853e-01	Baiap3	up
33	DMKN	DMKN	-0.3291229	0.1606125	-2.049173	0.0404452	0.0368210	0.0404452	0.0393216	7.195546e-01	0.5252307	9.857741e-01	Dmkn	up
115	SPRY3	SPRY3	0.4960903	0.2418322	2.051382	0.0402298	0.0386226	0.0402298	0.0404007	1.642288e+00	1.0223540	2.638136e+00	Spry3	up
2	ABHD3	ABHD3	0.5955091	0.2929307	2.032935	0.0420591	0.0407117	0.0420591	0.0409840	1.813954e+00	1.0216055	3.220842e+00	Abhd3	up
18	CD5L	CD5L	0.7754014	0.3848963	2.014572	0.0439495	0.1129359	0.0439495	0.0414056	2.171464e+00	1.0212410	4.617181e+00	Cd5l	down
58	LGI3	LGI3	0.1822722	0.0897599	2.030665	0.0422890	0.0443037	0.0422890	0.0414997	1.199941e+00	1.0063663	1.430749e+00	Lgi3	up
99	RSPO3	RSPO3	-0.6746499	0.3363098	-2.006037	0.0448523	0.0301619	0.0448523	0.0427121	5.093347e-01	0.2634728	9.846247e-01	Rspo3	up
32	DCHS2	DCHS2	-1.0486217	0.5210343	-2.012577	0.0441591	0.0349509	0.0441591	0.0427312	3.504204e-01	0.1262072	9.729591e-01	Dchs2	up
35	DNAH12	DNAH12	3.9025793	1.9420087	2.009558	0.0444780	0.0681526	0.0444780	0.0436603	4.953004e+01	1.1011029	2.227971e+03	Dnah12	up
31	CYB561	CYB561	-0.3508557	0.1754585	-1.999651	0.0455380	0.0350770	0.0455380	0.0445372	7.040854e-01	0.4992003	9.930608e-01	Cyb561	up
48	GPR176	GPR176	0.3455603	0.1729604	1.997916	0.0457257	0.0478815	0.0457257	0.0446132	1.412781e+00	1.0065858	1.982892e+00	Gpr176	up
34	DMRTC1	DMRTC1	98.5643120	49.8616264	1.976757	0.0480691	0.0630351	0.0480691	0.0448591	6.396418e+42	2.3101676	1.771047e+85	Dmrtc1a	up
116	SPTBN5	SPTBN5	0.6025659	0.3021065	1.994548	0.0460922	0.0585582	0.0460922	0.0449381	1.826800e+00	1.0105029	3.302513e+00	Sptbn5	up
8	ARPP21	ARPP21	-0.3743726	0.1867061	-2.005144	0.0449477	0.0462126	0.0449477	0.0451881	6.877206e-01	0.4769661	9.916001e-01	Arpp21	up
7	ALDOC	ALDOC	-0.2765491	0.1381129	-2.002341	0.0452480	0.0542366	0.0452480	0.0455496	7.583964e-01	0.5785413	9.941643e-01	Aldoc	up
23	CHST1	CHST1	-0.2144981	0.1081277	-1.983748	0.0472839	0.0521806	0.0472839	0.0467366	8.069463e-01	0.6528391	9.974316e-01	Chst1	up
131	WNT4	WNT4	-0.7042827	0.3598625	-1.957089	0.0503371	0.0247391	0.0503371	0.0469690	4.944631e-01	0.2442409	1.001035e+00	Wnt4	up
20	CDK6	CDK6	0.3824756	0.1938366	1.973185	0.0484744	0.0528413	0.0484744	0.0485995	1.465909e+00	1.0025661	2.143389e+00	Cdk6	down
97	RASGRF1	RASGRF1	-0.2693178	0.1370775	-1.964712	0.0494476	0.0439386	0.0494476	0.0487218	7.639004e-01	0.5839238	9.993493e-01	Rasgrf1	up
4	ADAMTS3	ADAMTS3	1.9769091	0.9586936	2.062086	0.0391995	0.0865033	0.0391995	0.0488657	7.220391e+00	1.1028571	4.727180e+01	Adamts3	up
119	SYT3	SYT3	-0.3410561	0.1739619	-1.960522	0.0499348	0.0391895	0.0499348	0.0489593	7.110190e-01	0.5055971	9.999029e-01	Syt3	up
81	PCDHGA4	PCDHGA4	1.0331251	0.5206786	1.984190	0.0472347	0.0638059	0.0472347	0.0497464	2.809833e+00	1.0126938	7.796199e+00	Pcdhga4	up
63	LSAMP	LSAMP	-0.6089189	0.3110885	-1.957382	0.0503026	0.0520013	0.0503026	0.0499826	5.439386e-01	0.2956316	1.000804e+00	Lsamp	up

ONLY IDH

Gene-sets considered

UP and DOWN

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Table genes

	Variable	Term	Beta	StandardError	Z	P	LRT	Wald	LogRank	HR	HRlower	HRupper	mm	status
47	GPR139	GPR139	2.9954716	0.5459944	5.486268	0.0000000	0.0000008	0.0000000	0.0000000	1.999479e+01	6.8574946	5.829993e+01	Gpr139	up
11	BVES	BVES	0.7842063	0.1424517	5.505070	0.0000000	0.0000025	0.0000000	0.0000001	2.190667e+00	1.6569958	2.896220e+00	Bves	up
22	CHIC2	CHIC2	1.1744777	0.2267115	5.180495	0.0000002	0.0000079	0.0000002	0.0000002	3.236452e+00	2.0753531	5.047152e+00	Chic2	down
62	LRRK2	LRRK2	0.6724442	0.1341983	5.010825	0.0000005	0.0000059	0.0000005	0.0000002	1.959020e+00	1.5059447	2.548406e+00	Lrrk2	up
21	CEP135	CEP135	1.1901584	0.2479228	4.800520	0.0000016	0.0000491	0.0000016	0.0000014	3.287602e+00	2.0223064	5.344554e+00	Cep135	down
133	ZBTB8B	ZBTB8B	1.1045218	0.2349319	4.701455	0.0000026	0.0000192	0.0000026	0.0000022	3.017781e+00	1.9042034	4.782579e+00	Zbtb8b	up
86	PI4K2B	PI4K2B	1.0371524	0.2498474	4.151143	0.0000331	0.0015532	0.0000331	0.0000217	2.821172e+00	1.7288568	4.603626e+00	Pi4k2b	down
102	SERINC2	SERINC2	0.6263722	0.1610620	3.889012	0.0001007	0.0002453	0.0001007	0.0000827	1.870811e+00	1.3643749	2.565230e+00	Serinc2	up
104	SH3GL2	SH3GL2	-0.7907620	0.2005988	-3.942008	0.0000808	0.0000695	0.0000808	0.0001115	4.534991e-01	0.3060740	6.719337e-01	Sh3gl2	up
15	CCDC87	CCDC87	-0.7788043	0.2036870	-3.823535	0.0001316	0.0001516	0.0001316	0.0001223	4.589545e-01	0.3078867	6.841452e-01	Ccdc87	up
80	PCDHGA3	PCDHGA3	0.6336887	0.1854916	3.416266	0.0006349	0.0047731	0.0006349	0.0001990	1.884549e+00	1.3101371	2.710805e+00	Pcdhga3	up
101	SEPSECS	SEPSECS	1.0745060	0.2684215	4.003055	0.0000625	0.0004790	0.0000625	0.0002610	2.928546e+00	1.7304985	4.956017e+00	Sepsecs	down
78	PAX5	PAX5	4.3732708	1.3013911	3.360458	0.0007781	0.0111408	0.0007781	0.0002911	7.930259e+01	6.1878707	1.016327e+03	Pax5	down
54	KCNG1	KCNG1	-0.5347163	0.1540201	-3.471731	0.0005171	0.0001938	0.0005171	0.0004520	5.858355e-01	0.4331851	7.922784e-01	Kcng1	up
85	PHKG1	PHKG1	-0.3998301	0.1165522	-3.430480	0.0006025	0.0009269	0.0006025	0.0004617	6.704339e-01	0.5335149	8.424913e-01	Phkg1	up
50	HHIP	HHIP	0.5367070	0.1575686	3.406179	0.0006588	0.0014311	0.0006588	0.0005304	1.710365e+00	1.2559323	2.329225e+00	Hhip	up
36	EFCAB6	EFCAB6	-7.0065194	2.0604116	-3.400543	0.0006725	0.0002490	0.0006725	0.0005886	9.060000e-04	0.0000160	5.139640e-02	Efcab6	up
68	METTL11B	METTL11B	2.6216611	0.8373169	3.131026	0.0017420	0.0097680	0.0017420	0.0007621	1.375856e+01	2.6659224	7.100655e+01	Mettl11b	up
89	PLCXD1	PLCXD1	0.6979770	0.2051305	3.402601	0.0006675	0.0009493	0.0006675	0.0007977	2.009683e+00	1.3443743	3.004242e+00	Plcxd1	up
25	CLEC18A	CLEC18A	2.0090652	0.6175386	3.253344	0.0011406	0.0037224	0.0011406	0.0009366	7.456344e+00	2.2226761	2.501357e+01	Clec18a	up
82	PCDHGA8	PCDHGA8	4.5064285	1.4663795	3.073167	0.0021180	0.0114419	0.0021180	0.0016940	9.059767e+01	5.1160230	1.604359e+03	Pcdhga8	up
79	PCDH7	PCDH7	-0.7147787	0.2368258	-3.018163	0.0025431	0.0019136	0.0025431	0.0024481	4.893004e-01	0.3076020	7.783268e-01	Pcdh7	up
17	CCNB2	CCNB2	0.3221457	0.1089420	2.957039	0.0031061	0.0046368	0.0031061	0.0027830	1.380086e+00	1.1147424	1.708589e+00	Ccnb2	down
1	ABCA8	ABCA8	0.4256288	0.1413422	3.011336	0.0026010	0.0059862	0.0026010	0.0030725	1.530552e+00	1.1602125	2.019105e+00	Abca8b	up
43	GDF10	GDF10	-0.3061819	0.1055962	-2.899555	0.0037369	0.0022250	0.0037369	0.0032660	7.362527e-01	0.5986090	9.055460e-01	Gdf10	up
44	GJA1	GJA1	-0.4050831	0.1380017	-2.935349	0.0033317	0.0035724	0.0033317	0.0034714	6.669214e-01	0.5088706	8.740613e-01	Gja1	up
29	CRTAC1	CRTAC1	-0.5539521	0.1912721	-2.896147	0.0037778	0.0040257	0.0037778	0.0037843	5.746742e-01	0.3950123	8.360510e-01	Crtac1	up
74	NRG3	NRG3	-2.4032161	0.8375289	-2.869413	0.0041123	0.0031459	0.0041123	0.0039243	9.042670e-02	0.0175142	4.668770e-01	Nrg3	up
123	TPSAB1	TPSAB1	-0.7426437	0.2748043	-2.702446	0.0068831	0.0004653	0.0068831	0.0039419	4.758542e-01	0.2776899	8.154320e-01	Tpsb2	down
128	TUB	TUB	-0.5196510	0.1808249	-2.873780	0.0040559	0.0047320	0.0040559	0.0041056	5.947281e-01	0.4172535	8.476897e-01	Tub	up
103	SFTPC	SFTPC	0.4223342	0.1487355	2.839498	0.0045185	0.0058762	0.0045185	0.0041667	1.525518e+00	1.1397603	2.041838e+00	Sftpc	up
120	TCHH	TCHH	-0.5988549	0.2142769	-2.794771	0.0051936	0.0025865	0.0051936	0.0050215	5.494404e-01	0.3610171	8.362064e-01	Tchh	up
130	VWC2	VWC2	-0.8118496	0.2985573	-2.719242	0.0065432	0.0042834	0.0065432	0.0057806	4.440360e-01	0.2473351	7.971695e-01	Vwc2	up
27	CNGA4	CNGA4	-1.0359853	0.3821171	-2.711172	0.0067046	0.0040296	0.0067046	0.0063590	3.548765e-01	0.1678103	7.504746e-01	Cnga4	up
114	SPHKAP	SPHKAP	-0.4625777	0.1721975	-2.686321	0.0072244	0.0065275	0.0072244	0.0068047	6.296585e-01	0.4492936	8.824291e-01	Sphkap	up
46	GLT8D2	GLT8D2	-1.6440659	0.6170412	-2.664435	0.0077118	0.0045787	0.0077118	0.0071151	1.931929e-01	0.0576454	6.474670e-01	Glt8d2	up
40	FAM186B	FAM186B	2.7648858	1.0270985	2.691938	0.0071038	0.0102688	0.0071038	0.0071928	1.587723e+01	2.1208349	1.188618e+02	Fam186b	up
5	ADCY2	ADCY2	-0.5091532	0.1915128	-2.658586	0.0078469	0.0086014	0.0078469	0.0075234	6.010043e-01	0.4129159	8.747693e-01	Adcy2	up
87	PLA2G4E	PLA2G4E	19.0823473	7.2463960	2.633357	0.0084545	0.0379296	0.0084545	0.0081310	1.938019e+08	131.5875091	2.854313e+14	Pla2g4e	up
96	RAB42	RAB42	0.5038644	0.1915025	2.631111	0.0085106	0.0086515	0.0085106	0.0084776	1.655105e+00	1.1371513	2.408978e+00	Rab42	up
73	NR3C2	NR3C2	-1.1889369	0.4523989	-2.628072	0.0085870	0.0066070	0.0085870	0.0085969	3.045449e-01	0.1254783	7.391523e-01	Nr3c2	up
60	LRRC18	LRRC18	0.8248612	0.3172093	2.600369	0.0093124	0.0202333	0.0093124	0.0094480	2.281564e+00	1.2252469	4.248560e+00	Lrrc18	up
66	MAP6D1	MAP6D1	0.3520670	0.1365555	2.578198	0.0099317	0.0104100	0.0099317	0.0094586	1.422004e+00	1.0880893	1.858390e+00	Map6d1	up
69	MGAT4C	MGAT4C	-1.3821722	0.5241332	-2.637063	0.0083627	0.0040005	0.0083627	0.0095399	2.510327e-01	0.0898643	7.012506e-01	Mgat4c	up
106	SLAIN2	SLAIN2	0.8455718	0.3292619	2.568083	0.0102263	0.0111327	0.0102263	0.0096223	2.329309e+00	1.2216841	4.441149e+00	Slain2	down
113	SPAG17	SPAG17	10.0872014	4.2371258	2.380671	0.0172812	0.0574988	0.0172812	0.0110288	2.403344e+04	5.9452191	9.715474e+07	Spag17	up
37	EFEMP1	EFEMP1	-0.2914440	0.1149583	-2.535214	0.0112379	0.0122232	0.0112379	0.0111204	7.471839e-01	0.5964510	9.360093e-01	Efemp1	up
12	CACNA2D2	CACNA2D2	-0.8043295	0.3205444	-2.509261	0.0120984	0.0098839	0.0120984	0.0118147	4.473878e-01	0.2386911	8.385559e-01	Cacna2d2	up
55	KLF14	KLF14	1.6071670	0.6370812	2.522703	0.0116457	0.0346226	0.0116457	0.0119965	4.988658e+00	1.4311964	1.738875e+01	Klf14	up
127	TTLL7	TTLL7	0.4510948	0.1808449	2.494374	0.0126179	0.0140847	0.0126179	0.0121624	1.570030e+00	1.1014697	2.237914e+00	Ttll7	up
28	CPA3	CPA3	-2.6676371	1.2839007	-2.077760	0.0377315	0.0010779	0.0377315	0.0122039	6.941610e-02	0.0056053	8.596431e-01	Cpa3	down
94	PRIMA1	PRIMA1	0.6222890	0.2488279	2.500881	0.0123885	0.0134312	0.0123885	0.0122378	1.863188e+00	1.1440737	3.034306e+00	Prima1	up
110	SLC7A11	SLC7A11	-0.5173928	0.2068672	-2.501087	0.0123813	0.0111473	0.0123813	0.0128561	5.960726e-01	0.3973869	8.940974e-01	Slc7a11	up
83	PDGFRA	PDGFRA	0.3197732	0.1282574	2.493214	0.0126593	0.0114151	0.0126593	0.0129613	1.376815e+00	1.0707863	1.770307e+00	Pdgfra	down
65	MAGEE2	MAGEE2	0.2072085	0.0847911	2.443752	0.0145354	0.0121291	0.0145354	0.0129998	1.230239e+00	1.0418739	1.452659e+00	Magee2	up
26	CLMN	CLMN	0.5914685	0.2374123	2.491314	0.0127272	0.0186262	0.0127272	0.0131366	1.806639e+00	1.1344511	2.877115e+00	Clmn	up
93	PPP2R2B	PPP2R2B	-0.7571162	0.3070699	-2.465615	0.0136778	0.0122080	0.0136778	0.0135049	4.690170e-01	0.2569273	8.561837e-01	Ppp2r2b	up
70	MSR1	MSR1	0.6293928	0.2584362	2.435390	0.0148758	0.0257520	0.0148758	0.0144026	1.876471e+00	1.1307343	3.114032e+00	Msr1	down
16	CCL27	CCL27	-10.1807420	4.9394362	-2.061114	0.0392921	0.0011244	0.0392921	0.0147958	3.790000e-05	0.0000000	6.067582e-01	Ccl27a	up
111	SLITRK5	SLITRK5	-0.4852339	0.1987193	-2.441806	0.0146140	0.0166802	0.0146140	0.0148097	6.155532e-01	0.4169802	9.086900e-01	Slitrk5	up
121	TFCP2L1	TFCP2L1	0.4640884	0.1932673	2.401277	0.0163379	0.0254705	0.0163379	0.0148488	1.590564e+00	1.0890344	2.323060e+00	Tfcp2l1	up
100	SCUBE3	SCUBE3	0.5114631	0.2125001	2.406884	0.0160893	0.0256815	0.0160893	0.0148709	1.667729e+00	1.0996264	2.529333e+00	Scube3	up
134	ZCCHC3	ZCCHC3	0.8449587	0.3501292	2.413277	0.0158098	0.0144719	0.0158098	0.0157013	2.327882e+00	1.1720075	4.623719e+00	Zcchc3	up
6	AHCYL2	AHCYL2	-0.4618186	0.1916865	-2.409239	0.0159858	0.0144949	0.0159858	0.0157534	6.301366e-01	0.4327837	9.174842e-01	Ahcyl2	up
84	PELI3	PELI3	-0.5361502	0.2219673	-2.415447	0.0157159	0.0125532	0.0157159	0.0158807	5.849960e-01	0.3786292	9.038405e-01	Peli3	up
117	SYT12	SYT12	-0.3974626	0.1658915	-2.395919	0.0165787	0.0103877	0.0165787	0.0161174	6.720231e-01	0.4854864	9.302320e-01	Syt12	up
61	LRRC6	LRRC6	-1.2100537	0.5083194	-2.380499	0.0172892	0.0148202	0.0172892	0.0162693	2.981813e-01	0.1101027	8.075373e-01	Lrrc6	up
77	OSR1	OSR1	0.2144682	0.0905432	2.368683	0.0178516	0.0251440	0.0178516	0.0166777	1.239203e+00	1.0377000	1.479834e+00	Osr1	up
90	PLK5	PLK5	-0.5414021	0.2291631	-2.362518	0.0181512	0.0166165	0.0181512	0.0175387	5.819318e-01	0.3713711	9.118766e-01	Plk5	up
59	LIX1	LIX1	-0.2840070	0.1205932	-2.355083	0.0185186	0.0237242	0.0185186	0.0177018	7.527614e-01	0.5943034	9.534687e-01	Lix1	up
45	GLRA3	GLRA3	-0.6180356	0.2634646	-2.345801	0.0189862	0.0133041	0.0189862	0.0185040	5.390022e-01	0.3216097	9.033416e-01	Glra3	up
71	NIPAL3	NIPAL3	0.3068599	0.1315510	2.332631	0.0196675	0.0202769	0.0196675	0.0189767	1.359150e+00	1.0502462	1.758911e+00	Nipal3	up
75	NSUN7	NSUN7	2.8988354	1.2476243	2.323484	0.0201532	0.0274793	0.0201532	0.0194083	1.815299e+01	1.5738687	2.093765e+02	Nsun7	up
3	ABLIM3	ABLIM3	-0.4204272	0.1804536	-2.329836	0.0198148	0.0196918	0.0198148	0.0196757	6.567662e-01	0.4611141	9.354340e-01	Ablim3	up
98	RNF32	RNF32	-0.7549155	0.3244026	-2.327095	0.0199602	0.0195812	0.0199602	0.0197767	4.700503e-01	0.2488928	8.877207e-01	Rnf32	up
30	CRYBB1	CRYBB1	-0.6109657	0.2598025	-2.351655	0.0186901	0.0162412	0.0186901	0.0199216	5.428264e-01	0.3262246	9.032443e-01	Crybb1	up
122	TNNI1	TNNI1	2.8923203	1.3335905	2.168822	0.0300962	0.0799377	0.0300962	0.0199732	1.803511e+01	1.3211876	2.461915e+02	Tnni1	up
91	POPDC3	POPDC3	0.3123546	0.1361879	2.293555	0.0218161	0.0284385	0.0218161	0.0201892	1.366639e+00	1.0464789	1.784749e+00	Popdc3	up
14	CAMSAP3	CAMSAP3	-0.2662145	0.1163447	-2.288152	0.0221286	0.0232764	0.0221286	0.0215514	7.662747e-01	0.6100307	9.625368e-01	Camsap3	up
42	FZD2	FZD2	0.3875964	0.1688566	2.295418	0.0217092	0.0214499	0.0217092	0.0216465	1.473435e+00	1.0582785	2.051455e+00	Fzd2	up
135	ZCCHC4	ZCCHC4	0.7571164	0.3109674	2.434713	0.0149036	0.0324878	0.0149036	0.0221649	2.132119e+00	1.1590857	3.921998e+00	Zcchc4	down
124	TPSB2	TPSB2	-0.4678065	0.2090684	-2.237576	0.0252487	0.0102559	0.0252487	0.0225107	6.263747e-01	0.4157908	9.436123e-01	Tpsb2	down
109	SLC4A4	SLC4A4	-0.4141597	0.1824616	-2.269846	0.0232169	0.0246088	0.0232169	0.0226269	6.608954e-01	0.4621906	9.450271e-01	Slc4a4	up
52	HTR2C	HTR2C	-3.1565775	1.3995778	-2.255378	0.0241096	0.0133067	0.0241096	0.0232918	4.257120e-02	0.0027403	6.613610e-01	Htr2c	up
108	SLC35F4	SLC35F4	6.9660928	3.4145385	2.040127	0.0413377	0.1207829	0.0413377	0.0234941	1.060073e+03	1.3148471	8.546653e+05	Slc35f4	up
39	FAM111A	FAM111A	0.4931808	0.2189509	2.252472	0.0242925	0.0261799	0.0242925	0.0238429	1.637517e+00	1.0661403	2.515110e+00	Fam111a	down
118	SYT17	SYT17	-0.6691720	0.2974328	-2.249826	0.0244600	0.0230309	0.0244600	0.0240354	5.121324e-01	0.2858953	9.173975e-01	Syt17	up
95	PROK2	PROK2	1.8148931	0.8212733	2.209853	0.0271154	0.0412250	0.0271154	0.0258169	6.140420e+00	1.2278037	3.070911e+01	Prok2	up
136	ZNF519	ZNF519	0.7099944	0.3196717	2.221011	0.0263502	0.0282681	0.0263502	0.0258965	2.033980e+00	1.0870303	3.805850e+00	Zfp941	up
92	PPIL6	PPIL6	-0.8190445	0.3663250	-2.235841	0.0253622	0.0228182	0.0253622	0.0262949	4.408527e-01	0.2150191	9.038782e-01	Ppil6	up
67	MEIG1	MEIG1	-1.4153405	0.6416480	-2.205790	0.0273987	0.0165410	0.0273987	0.0263250	2.428429e-01	0.0690484	8.540773e-01	Meig1	up
41	FRY	FRY	-0.6736747	0.3074954	-2.190845	0.0284630	0.0283663	0.0284630	0.0281425	5.098316e-01	0.2790527	9.314667e-01	Fry	up
24	CHST15	CHST15	-0.4167445	0.1902333	-2.190702	0.0284734	0.0278526	0.0284734	0.0281733	6.591893e-01	0.4540287	9.570553e-01	Chst15	up
19	CDH7	CDH7	-0.6616486	0.3054743	-2.165971	0.0303134	0.0216067	0.0303134	0.0286263	5.160000e-01	0.2835499	9.390093e-01	Cdh7	up
57	KNDC1	KNDC1	-0.2969632	0.1366881	-2.172560	0.0298134	0.0279141	0.0298134	0.0293196	7.430714e-01	0.5684358	9.713588e-01	Kndc1	up
125	TTC34	TTC34	-3.7733836	1.7457180	-2.161508	0.0306561	0.0235946	0.0306561	0.0297951	2.297420e-02	0.0007504	7.033933e-01	Ttc34	up
49	HHATL	HHATL	0.2470745	0.1144943	2.157963	0.0309307	0.0303280	0.0309307	0.0308650	1.280274e+00	1.0229287	1.602363e+00	Hhatl	up
53	KCNB1	KCNB1	-0.4829054	0.2251743	-2.144585	0.0319861	0.0281475	0.0319861	0.0316609	6.169882e-01	0.3968333	9.592804e-01	Kcnb1	up
51	HS6ST2	HS6ST2	0.8537621	0.4008883	2.129676	0.0331984	0.0357143	0.0331984	0.0317125	2.348466e+00	1.0704032	5.152535e+00	Hs6st2	up
126	TTLL11	TTLL11	1.3664702	0.6377193	2.142745	0.0321335	0.0412975	0.0321335	0.0321406	3.921484e+00	1.1236286	1.368605e+01	Ttll11	up
72	NLRP6	NLRP6	0.5442128	0.2548265	2.135621	0.0327103	0.0448962	0.0327103	0.0322133	1.723251e+00	1.0457789	2.839601e+00	Nlrp6	up
64	LUZP2	LUZP2	-0.3671389	0.1727341	-2.125457	0.0335485	0.0367364	0.0335485	0.0323780	6.927134e-01	0.4937670	9.718185e-01	Luzp2	up
10	BRINP1	BRINP1	-0.3392242	0.1600891	-2.118972	0.0340928	0.0305033	0.0340928	0.0324119	7.123227e-01	0.5204856	9.748658e-01	Brinp1	up
56	KLHDC9	KLHDC9	-0.2353128	0.1106619	-2.126413	0.0334689	0.0371299	0.0334689	0.0330566	7.903236e-01	0.6362230	9.817491e-01	Klhdc9	up
88	PLCB1	PLCB1	-0.6420079	0.3024846	-2.122448	0.0338001	0.0324093	0.0338001	0.0333069	5.262348e-01	0.2908735	9.520392e-01	Plcb1	up
105	SIDT1	SIDT1	-0.4174642	0.1983770	-2.104398	0.0353437	0.0278401	0.0353437	0.0339631	6.587150e-01	0.4465178	9.717541e-01	Sidt1	up
107	SLC1A2	SLC1A2	-0.2124443	0.1003561	-2.116904	0.0342680	0.0375824	0.0342680	0.0340428	8.086053e-01	0.6642221	9.843735e-01	Slc1a2	up
38	EMID1	EMID1	-0.4502308	0.2133506	-2.110287	0.0348337	0.0338802	0.0348337	0.0343860	6.374810e-01	0.4196265	9.684374e-01	Emid1	up
13	CACNA2D4	CACNA2D4	1.0245697	0.4891258	2.094696	0.0361980	0.0427101	0.0361980	0.0350024	2.785896e+00	1.0681207	7.266237e+00	Cacna2d4	up
76	NXPH3	NXPH3	-0.3774392	0.1806948	-2.088822	0.0367238	0.0409742	0.0367238	0.0363733	6.856149e-01	0.4811412	9.769850e-01	Nxph3	up
129	UNC13B	UNC13B	-0.7827685	0.3736143	-2.095125	0.0361599	0.0336327	0.0361599	0.0369294	4.571387e-01	0.2197996	9.507559e-01	Unc13b	up
132	WNT9A	WNT9A	0.6958626	0.3367280	2.066542	0.0387773	0.0463104	0.0387773	0.0378423	2.005438e+00	1.0365397	3.880008e+00	Wnt9a	up
112	SMIM1	SMIM1	0.5206950	0.2527491	2.060126	0.0393865	0.0428917	0.0393865	0.0385225	1.683197e+00	1.0256390	2.762329e+00	Smim1	up
9	BAIAP3	BAIAP3	-0.2794113	0.1351514	-2.067396	0.0386969	0.0418946	0.0386969	0.0390339	7.562288e-01	0.5802460	9.855853e-01	Baiap3	up
33	DMKN	DMKN	-0.3291229	0.1606125	-2.049173	0.0404452	0.0368210	0.0404452	0.0393216	7.195546e-01	0.5252307	9.857741e-01	Dmkn	up
115	SPRY3	SPRY3	0.4960903	0.2418322	2.051382	0.0402298	0.0386226	0.0402298	0.0404007	1.642288e+00	1.0223540	2.638136e+00	Spry3	up
2	ABHD3	ABHD3	0.5955091	0.2929307	2.032935	0.0420591	0.0407117	0.0420591	0.0409840	1.813954e+00	1.0216055	3.220842e+00	Abhd3	up
18	CD5L	CD5L	0.7754014	0.3848963	2.014572	0.0439495	0.1129359	0.0439495	0.0414056	2.171464e+00	1.0212410	4.617181e+00	Cd5l	down
58	LGI3	LGI3	0.1822722	0.0897599	2.030665	0.0422890	0.0443037	0.0422890	0.0414997	1.199941e+00	1.0063663	1.430749e+00	Lgi3	up
99	RSPO3	RSPO3	-0.6746499	0.3363098	-2.006037	0.0448523	0.0301619	0.0448523	0.0427121	5.093347e-01	0.2634728	9.846247e-01	Rspo3	up
32	DCHS2	DCHS2	-1.0486217	0.5210343	-2.012577	0.0441591	0.0349509	0.0441591	0.0427312	3.504204e-01	0.1262072	9.729591e-01	Dchs2	up
35	DNAH12	DNAH12	3.9025793	1.9420087	2.009558	0.0444780	0.0681526	0.0444780	0.0436603	4.953004e+01	1.1011029	2.227971e+03	Dnah12	up
31	CYB561	CYB561	-0.3508557	0.1754585	-1.999651	0.0455380	0.0350770	0.0455380	0.0445372	7.040854e-01	0.4992003	9.930608e-01	Cyb561	up
48	GPR176	GPR176	0.3455603	0.1729604	1.997916	0.0457257	0.0478815	0.0457257	0.0446132	1.412781e+00	1.0065858	1.982892e+00	Gpr176	up
34	DMRTC1	DMRTC1	98.5643120	49.8616264	1.976757	0.0480691	0.0630351	0.0480691	0.0448591	6.396418e+42	2.3101676	1.771047e+85	Dmrtc1a	up
116	SPTBN5	SPTBN5	0.6025659	0.3021065	1.994548	0.0460922	0.0585582	0.0460922	0.0449381	1.826800e+00	1.0105029	3.302513e+00	Sptbn5	up
8	ARPP21	ARPP21	-0.3743726	0.1867061	-2.005144	0.0449477	0.0462126	0.0449477	0.0451881	6.877206e-01	0.4769661	9.916001e-01	Arpp21	up
7	ALDOC	ALDOC	-0.2765491	0.1381129	-2.002341	0.0452480	0.0542366	0.0452480	0.0455496	7.583964e-01	0.5785413	9.941643e-01	Aldoc	up
23	CHST1	CHST1	-0.2144981	0.1081277	-1.983748	0.0472839	0.0521806	0.0472839	0.0467366	8.069463e-01	0.6528391	9.974316e-01	Chst1	up
131	WNT4	WNT4	-0.7042827	0.3598625	-1.957089	0.0503371	0.0247391	0.0503371	0.0469690	4.944631e-01	0.2442409	1.001035e+00	Wnt4	up
20	CDK6	CDK6	0.3824756	0.1938366	1.973185	0.0484744	0.0528413	0.0484744	0.0485995	1.465909e+00	1.0025661	2.143389e+00	Cdk6	down
97	RASGRF1	RASGRF1	-0.2693178	0.1370775	-1.964712	0.0494476	0.0439386	0.0494476	0.0487218	7.639004e-01	0.5839238	9.993493e-01	Rasgrf1	up
4	ADAMTS3	ADAMTS3	1.9769091	0.9586936	2.062086	0.0391995	0.0865033	0.0391995	0.0488657	7.220391e+00	1.1028571	4.727180e+01	Adamts3	up
119	SYT3	SYT3	-0.3410561	0.1739619	-1.960522	0.0499348	0.0391895	0.0499348	0.0489593	7.110190e-01	0.5055971	9.999029e-01	Syt3	up
81	PCDHGA4	PCDHGA4	1.0331251	0.5206786	1.984190	0.0472347	0.0638059	0.0472347	0.0497464	2.809833e+00	1.0126938	7.796199e+00	Pcdhga4	up
63	LSAMP	LSAMP	-0.6089189	0.3110885	-1.957382	0.0503026	0.0520013	0.0503026	0.0499826	5.439386e-01	0.2956316	1.000804e+00	Lsamp	up

IDH_CODEL_NOCODEL

Gene-sets considered

UP and DOWN

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Table genes

	Variable	Term	Beta	StandardError	Z	P	LRT	Wald	LogRank	HR	HRlower	HRupper	mm	status
47	GPR139	GPR139	2.9954716	0.5459944	5.486268	0.0000000	0.0000008	0.0000000	0.0000000	1.999479e+01	6.8574946	5.829993e+01	Gpr139	up
11	BVES	BVES	0.7842063	0.1424517	5.505070	0.0000000	0.0000025	0.0000000	0.0000001	2.190667e+00	1.6569958	2.896220e+00	Bves	up
22	CHIC2	CHIC2	1.1744777	0.2267115	5.180495	0.0000002	0.0000079	0.0000002	0.0000002	3.236452e+00	2.0753531	5.047152e+00	Chic2	down
62	LRRK2	LRRK2	0.6724442	0.1341983	5.010825	0.0000005	0.0000059	0.0000005	0.0000002	1.959020e+00	1.5059447	2.548406e+00	Lrrk2	up
21	CEP135	CEP135	1.1901584	0.2479228	4.800520	0.0000016	0.0000491	0.0000016	0.0000014	3.287602e+00	2.0223064	5.344554e+00	Cep135	down
133	ZBTB8B	ZBTB8B	1.1045218	0.2349319	4.701455	0.0000026	0.0000192	0.0000026	0.0000022	3.017781e+00	1.9042034	4.782579e+00	Zbtb8b	up
86	PI4K2B	PI4K2B	1.0371524	0.2498474	4.151143	0.0000331	0.0015532	0.0000331	0.0000217	2.821172e+00	1.7288568	4.603626e+00	Pi4k2b	down
102	SERINC2	SERINC2	0.6263722	0.1610620	3.889012	0.0001007	0.0002453	0.0001007	0.0000827	1.870811e+00	1.3643749	2.565230e+00	Serinc2	up
104	SH3GL2	SH3GL2	-0.7907620	0.2005988	-3.942008	0.0000808	0.0000695	0.0000808	0.0001115	4.534991e-01	0.3060740	6.719337e-01	Sh3gl2	up
15	CCDC87	CCDC87	-0.7788043	0.2036870	-3.823535	0.0001316	0.0001516	0.0001316	0.0001223	4.589545e-01	0.3078867	6.841452e-01	Ccdc87	up
80	PCDHGA3	PCDHGA3	0.6336887	0.1854916	3.416266	0.0006349	0.0047731	0.0006349	0.0001990	1.884549e+00	1.3101371	2.710805e+00	Pcdhga3	up
101	SEPSECS	SEPSECS	1.0745060	0.2684215	4.003055	0.0000625	0.0004790	0.0000625	0.0002610	2.928546e+00	1.7304985	4.956017e+00	Sepsecs	down
78	PAX5	PAX5	4.3732708	1.3013911	3.360458	0.0007781	0.0111408	0.0007781	0.0002911	7.930259e+01	6.1878707	1.016327e+03	Pax5	down
54	KCNG1	KCNG1	-0.5347163	0.1540201	-3.471731	0.0005171	0.0001938	0.0005171	0.0004520	5.858355e-01	0.4331851	7.922784e-01	Kcng1	up
85	PHKG1	PHKG1	-0.3998301	0.1165522	-3.430480	0.0006025	0.0009269	0.0006025	0.0004617	6.704339e-01	0.5335149	8.424913e-01	Phkg1	up
50	HHIP	HHIP	0.5367070	0.1575686	3.406179	0.0006588	0.0014311	0.0006588	0.0005304	1.710365e+00	1.2559323	2.329225e+00	Hhip	up
36	EFCAB6	EFCAB6	-7.0065194	2.0604116	-3.400543	0.0006725	0.0002490	0.0006725	0.0005886	9.060000e-04	0.0000160	5.139640e-02	Efcab6	up
68	METTL11B	METTL11B	2.6216611	0.8373169	3.131026	0.0017420	0.0097680	0.0017420	0.0007621	1.375856e+01	2.6659224	7.100655e+01	Mettl11b	up
89	PLCXD1	PLCXD1	0.6979770	0.2051305	3.402601	0.0006675	0.0009493	0.0006675	0.0007977	2.009683e+00	1.3443743	3.004242e+00	Plcxd1	up
25	CLEC18A	CLEC18A	2.0090652	0.6175386	3.253344	0.0011406	0.0037224	0.0011406	0.0009366	7.456344e+00	2.2226761	2.501357e+01	Clec18a	up
82	PCDHGA8	PCDHGA8	4.5064285	1.4663795	3.073167	0.0021180	0.0114419	0.0021180	0.0016940	9.059767e+01	5.1160230	1.604359e+03	Pcdhga8	up
79	PCDH7	PCDH7	-0.7147787	0.2368258	-3.018163	0.0025431	0.0019136	0.0025431	0.0024481	4.893004e-01	0.3076020	7.783268e-01	Pcdh7	up
17	CCNB2	CCNB2	0.3221457	0.1089420	2.957039	0.0031061	0.0046368	0.0031061	0.0027830	1.380086e+00	1.1147424	1.708589e+00	Ccnb2	down
1	ABCA8	ABCA8	0.4256288	0.1413422	3.011336	0.0026010	0.0059862	0.0026010	0.0030725	1.530552e+00	1.1602125	2.019105e+00	Abca8b	up
43	GDF10	GDF10	-0.3061819	0.1055962	-2.899555	0.0037369	0.0022250	0.0037369	0.0032660	7.362527e-01	0.5986090	9.055460e-01	Gdf10	up
44	GJA1	GJA1	-0.4050831	0.1380017	-2.935349	0.0033317	0.0035724	0.0033317	0.0034714	6.669214e-01	0.5088706	8.740613e-01	Gja1	up
29	CRTAC1	CRTAC1	-0.5539521	0.1912721	-2.896147	0.0037778	0.0040257	0.0037778	0.0037843	5.746742e-01	0.3950123	8.360510e-01	Crtac1	up
74	NRG3	NRG3	-2.4032161	0.8375289	-2.869413	0.0041123	0.0031459	0.0041123	0.0039243	9.042670e-02	0.0175142	4.668770e-01	Nrg3	up
123	TPSAB1	TPSAB1	-0.7426437	0.2748043	-2.702446	0.0068831	0.0004653	0.0068831	0.0039419	4.758542e-01	0.2776899	8.154320e-01	Tpsb2	down
128	TUB	TUB	-0.5196510	0.1808249	-2.873780	0.0040559	0.0047320	0.0040559	0.0041056	5.947281e-01	0.4172535	8.476897e-01	Tub	up
103	SFTPC	SFTPC	0.4223342	0.1487355	2.839498	0.0045185	0.0058762	0.0045185	0.0041667	1.525518e+00	1.1397603	2.041838e+00	Sftpc	up
120	TCHH	TCHH	-0.5988549	0.2142769	-2.794771	0.0051936	0.0025865	0.0051936	0.0050215	5.494404e-01	0.3610171	8.362064e-01	Tchh	up
130	VWC2	VWC2	-0.8118496	0.2985573	-2.719242	0.0065432	0.0042834	0.0065432	0.0057806	4.440360e-01	0.2473351	7.971695e-01	Vwc2	up
27	CNGA4	CNGA4	-1.0359853	0.3821171	-2.711172	0.0067046	0.0040296	0.0067046	0.0063590	3.548765e-01	0.1678103	7.504746e-01	Cnga4	up
114	SPHKAP	SPHKAP	-0.4625777	0.1721975	-2.686321	0.0072244	0.0065275	0.0072244	0.0068047	6.296585e-01	0.4492936	8.824291e-01	Sphkap	up
46	GLT8D2	GLT8D2	-1.6440659	0.6170412	-2.664435	0.0077118	0.0045787	0.0077118	0.0071151	1.931929e-01	0.0576454	6.474670e-01	Glt8d2	up
40	FAM186B	FAM186B	2.7648858	1.0270985	2.691938	0.0071038	0.0102688	0.0071038	0.0071928	1.587723e+01	2.1208349	1.188618e+02	Fam186b	up
5	ADCY2	ADCY2	-0.5091532	0.1915128	-2.658586	0.0078469	0.0086014	0.0078469	0.0075234	6.010043e-01	0.4129159	8.747693e-01	Adcy2	up
87	PLA2G4E	PLA2G4E	19.0823473	7.2463960	2.633357	0.0084545	0.0379296	0.0084545	0.0081310	1.938019e+08	131.5875091	2.854313e+14	Pla2g4e	up
96	RAB42	RAB42	0.5038644	0.1915025	2.631111	0.0085106	0.0086515	0.0085106	0.0084776	1.655105e+00	1.1371513	2.408978e+00	Rab42	up
73	NR3C2	NR3C2	-1.1889369	0.4523989	-2.628072	0.0085870	0.0066070	0.0085870	0.0085969	3.045449e-01	0.1254783	7.391523e-01	Nr3c2	up
60	LRRC18	LRRC18	0.8248612	0.3172093	2.600369	0.0093124	0.0202333	0.0093124	0.0094480	2.281564e+00	1.2252469	4.248560e+00	Lrrc18	up
66	MAP6D1	MAP6D1	0.3520670	0.1365555	2.578198	0.0099317	0.0104100	0.0099317	0.0094586	1.422004e+00	1.0880893	1.858390e+00	Map6d1	up
69	MGAT4C	MGAT4C	-1.3821722	0.5241332	-2.637063	0.0083627	0.0040005	0.0083627	0.0095399	2.510327e-01	0.0898643	7.012506e-01	Mgat4c	up
106	SLAIN2	SLAIN2	0.8455718	0.3292619	2.568083	0.0102263	0.0111327	0.0102263	0.0096223	2.329309e+00	1.2216841	4.441149e+00	Slain2	down
113	SPAG17	SPAG17	10.0872014	4.2371258	2.380671	0.0172812	0.0574988	0.0172812	0.0110288	2.403344e+04	5.9452191	9.715474e+07	Spag17	up
37	EFEMP1	EFEMP1	-0.2914440	0.1149583	-2.535214	0.0112379	0.0122232	0.0112379	0.0111204	7.471839e-01	0.5964510	9.360093e-01	Efemp1	up
12	CACNA2D2	CACNA2D2	-0.8043295	0.3205444	-2.509261	0.0120984	0.0098839	0.0120984	0.0118147	4.473878e-01	0.2386911	8.385559e-01	Cacna2d2	up
55	KLF14	KLF14	1.6071670	0.6370812	2.522703	0.0116457	0.0346226	0.0116457	0.0119965	4.988658e+00	1.4311964	1.738875e+01	Klf14	up
127	TTLL7	TTLL7	0.4510948	0.1808449	2.494374	0.0126179	0.0140847	0.0126179	0.0121624	1.570030e+00	1.1014697	2.237914e+00	Ttll7	up
28	CPA3	CPA3	-2.6676371	1.2839007	-2.077760	0.0377315	0.0010779	0.0377315	0.0122039	6.941610e-02	0.0056053	8.596431e-01	Cpa3	down
94	PRIMA1	PRIMA1	0.6222890	0.2488279	2.500881	0.0123885	0.0134312	0.0123885	0.0122378	1.863188e+00	1.1440737	3.034306e+00	Prima1	up
110	SLC7A11	SLC7A11	-0.5173928	0.2068672	-2.501087	0.0123813	0.0111473	0.0123813	0.0128561	5.960726e-01	0.3973869	8.940974e-01	Slc7a11	up
83	PDGFRA	PDGFRA	0.3197732	0.1282574	2.493214	0.0126593	0.0114151	0.0126593	0.0129613	1.376815e+00	1.0707863	1.770307e+00	Pdgfra	down
65	MAGEE2	MAGEE2	0.2072085	0.0847911	2.443752	0.0145354	0.0121291	0.0145354	0.0129998	1.230239e+00	1.0418739	1.452659e+00	Magee2	up
26	CLMN	CLMN	0.5914685	0.2374123	2.491314	0.0127272	0.0186262	0.0127272	0.0131366	1.806639e+00	1.1344511	2.877115e+00	Clmn	up
93	PPP2R2B	PPP2R2B	-0.7571162	0.3070699	-2.465615	0.0136778	0.0122080	0.0136778	0.0135049	4.690170e-01	0.2569273	8.561837e-01	Ppp2r2b	up
70	MSR1	MSR1	0.6293928	0.2584362	2.435390	0.0148758	0.0257520	0.0148758	0.0144026	1.876471e+00	1.1307343	3.114032e+00	Msr1	down
16	CCL27	CCL27	-10.1807420	4.9394362	-2.061114	0.0392921	0.0011244	0.0392921	0.0147958	3.790000e-05	0.0000000	6.067582e-01	Ccl27a	up
111	SLITRK5	SLITRK5	-0.4852339	0.1987193	-2.441806	0.0146140	0.0166802	0.0146140	0.0148097	6.155532e-01	0.4169802	9.086900e-01	Slitrk5	up
121	TFCP2L1	TFCP2L1	0.4640884	0.1932673	2.401277	0.0163379	0.0254705	0.0163379	0.0148488	1.590564e+00	1.0890344	2.323060e+00	Tfcp2l1	up
100	SCUBE3	SCUBE3	0.5114631	0.2125001	2.406884	0.0160893	0.0256815	0.0160893	0.0148709	1.667729e+00	1.0996264	2.529333e+00	Scube3	up
134	ZCCHC3	ZCCHC3	0.8449587	0.3501292	2.413277	0.0158098	0.0144719	0.0158098	0.0157013	2.327882e+00	1.1720075	4.623719e+00	Zcchc3	up
6	AHCYL2	AHCYL2	-0.4618186	0.1916865	-2.409239	0.0159858	0.0144949	0.0159858	0.0157534	6.301366e-01	0.4327837	9.174842e-01	Ahcyl2	up
84	PELI3	PELI3	-0.5361502	0.2219673	-2.415447	0.0157159	0.0125532	0.0157159	0.0158807	5.849960e-01	0.3786292	9.038405e-01	Peli3	up
117	SYT12	SYT12	-0.3974626	0.1658915	-2.395919	0.0165787	0.0103877	0.0165787	0.0161174	6.720231e-01	0.4854864	9.302320e-01	Syt12	up
61	LRRC6	LRRC6	-1.2100537	0.5083194	-2.380499	0.0172892	0.0148202	0.0172892	0.0162693	2.981813e-01	0.1101027	8.075373e-01	Lrrc6	up
77	OSR1	OSR1	0.2144682	0.0905432	2.368683	0.0178516	0.0251440	0.0178516	0.0166777	1.239203e+00	1.0377000	1.479834e+00	Osr1	up
90	PLK5	PLK5	-0.5414021	0.2291631	-2.362518	0.0181512	0.0166165	0.0181512	0.0175387	5.819318e-01	0.3713711	9.118766e-01	Plk5	up
59	LIX1	LIX1	-0.2840070	0.1205932	-2.355083	0.0185186	0.0237242	0.0185186	0.0177018	7.527614e-01	0.5943034	9.534687e-01	Lix1	up
45	GLRA3	GLRA3	-0.6180356	0.2634646	-2.345801	0.0189862	0.0133041	0.0189862	0.0185040	5.390022e-01	0.3216097	9.033416e-01	Glra3	up
71	NIPAL3	NIPAL3	0.3068599	0.1315510	2.332631	0.0196675	0.0202769	0.0196675	0.0189767	1.359150e+00	1.0502462	1.758911e+00	Nipal3	up
75	NSUN7	NSUN7	2.8988354	1.2476243	2.323484	0.0201532	0.0274793	0.0201532	0.0194083	1.815299e+01	1.5738687	2.093765e+02	Nsun7	up
3	ABLIM3	ABLIM3	-0.4204272	0.1804536	-2.329836	0.0198148	0.0196918	0.0198148	0.0196757	6.567662e-01	0.4611141	9.354340e-01	Ablim3	up
98	RNF32	RNF32	-0.7549155	0.3244026	-2.327095	0.0199602	0.0195812	0.0199602	0.0197767	4.700503e-01	0.2488928	8.877207e-01	Rnf32	up
30	CRYBB1	CRYBB1	-0.6109657	0.2598025	-2.351655	0.0186901	0.0162412	0.0186901	0.0199216	5.428264e-01	0.3262246	9.032443e-01	Crybb1	up
122	TNNI1	TNNI1	2.8923203	1.3335905	2.168822	0.0300962	0.0799377	0.0300962	0.0199732	1.803511e+01	1.3211876	2.461915e+02	Tnni1	up
91	POPDC3	POPDC3	0.3123546	0.1361879	2.293555	0.0218161	0.0284385	0.0218161	0.0201892	1.366639e+00	1.0464789	1.784749e+00	Popdc3	up
14	CAMSAP3	CAMSAP3	-0.2662145	0.1163447	-2.288152	0.0221286	0.0232764	0.0221286	0.0215514	7.662747e-01	0.6100307	9.625368e-01	Camsap3	up
42	FZD2	FZD2	0.3875964	0.1688566	2.295418	0.0217092	0.0214499	0.0217092	0.0216465	1.473435e+00	1.0582785	2.051455e+00	Fzd2	up
135	ZCCHC4	ZCCHC4	0.7571164	0.3109674	2.434713	0.0149036	0.0324878	0.0149036	0.0221649	2.132119e+00	1.1590857	3.921998e+00	Zcchc4	down
124	TPSB2	TPSB2	-0.4678065	0.2090684	-2.237576	0.0252487	0.0102559	0.0252487	0.0225107	6.263747e-01	0.4157908	9.436123e-01	Tpsb2	down
109	SLC4A4	SLC4A4	-0.4141597	0.1824616	-2.269846	0.0232169	0.0246088	0.0232169	0.0226269	6.608954e-01	0.4621906	9.450271e-01	Slc4a4	up
52	HTR2C	HTR2C	-3.1565775	1.3995778	-2.255378	0.0241096	0.0133067	0.0241096	0.0232918	4.257120e-02	0.0027403	6.613610e-01	Htr2c	up
108	SLC35F4	SLC35F4	6.9660928	3.4145385	2.040127	0.0413377	0.1207829	0.0413377	0.0234941	1.060073e+03	1.3148471	8.546653e+05	Slc35f4	up
39	FAM111A	FAM111A	0.4931808	0.2189509	2.252472	0.0242925	0.0261799	0.0242925	0.0238429	1.637517e+00	1.0661403	2.515110e+00	Fam111a	down
118	SYT17	SYT17	-0.6691720	0.2974328	-2.249826	0.0244600	0.0230309	0.0244600	0.0240354	5.121324e-01	0.2858953	9.173975e-01	Syt17	up
95	PROK2	PROK2	1.8148931	0.8212733	2.209853	0.0271154	0.0412250	0.0271154	0.0258169	6.140420e+00	1.2278037	3.070911e+01	Prok2	up
136	ZNF519	ZNF519	0.7099944	0.3196717	2.221011	0.0263502	0.0282681	0.0263502	0.0258965	2.033980e+00	1.0870303	3.805850e+00	Zfp941	up
92	PPIL6	PPIL6	-0.8190445	0.3663250	-2.235841	0.0253622	0.0228182	0.0253622	0.0262949	4.408527e-01	0.2150191	9.038782e-01	Ppil6	up
67	MEIG1	MEIG1	-1.4153405	0.6416480	-2.205790	0.0273987	0.0165410	0.0273987	0.0263250	2.428429e-01	0.0690484	8.540773e-01	Meig1	up
41	FRY	FRY	-0.6736747	0.3074954	-2.190845	0.0284630	0.0283663	0.0284630	0.0281425	5.098316e-01	0.2790527	9.314667e-01	Fry	up
24	CHST15	CHST15	-0.4167445	0.1902333	-2.190702	0.0284734	0.0278526	0.0284734	0.0281733	6.591893e-01	0.4540287	9.570553e-01	Chst15	up
19	CDH7	CDH7	-0.6616486	0.3054743	-2.165971	0.0303134	0.0216067	0.0303134	0.0286263	5.160000e-01	0.2835499	9.390093e-01	Cdh7	up
57	KNDC1	KNDC1	-0.2969632	0.1366881	-2.172560	0.0298134	0.0279141	0.0298134	0.0293196	7.430714e-01	0.5684358	9.713588e-01	Kndc1	up
125	TTC34	TTC34	-3.7733836	1.7457180	-2.161508	0.0306561	0.0235946	0.0306561	0.0297951	2.297420e-02	0.0007504	7.033933e-01	Ttc34	up
49	HHATL	HHATL	0.2470745	0.1144943	2.157963	0.0309307	0.0303280	0.0309307	0.0308650	1.280274e+00	1.0229287	1.602363e+00	Hhatl	up
53	KCNB1	KCNB1	-0.4829054	0.2251743	-2.144585	0.0319861	0.0281475	0.0319861	0.0316609	6.169882e-01	0.3968333	9.592804e-01	Kcnb1	up
51	HS6ST2	HS6ST2	0.8537621	0.4008883	2.129676	0.0331984	0.0357143	0.0331984	0.0317125	2.348466e+00	1.0704032	5.152535e+00	Hs6st2	up
126	TTLL11	TTLL11	1.3664702	0.6377193	2.142745	0.0321335	0.0412975	0.0321335	0.0321406	3.921484e+00	1.1236286	1.368605e+01	Ttll11	up
72	NLRP6	NLRP6	0.5442128	0.2548265	2.135621	0.0327103	0.0448962	0.0327103	0.0322133	1.723251e+00	1.0457789	2.839601e+00	Nlrp6	up
64	LUZP2	LUZP2	-0.3671389	0.1727341	-2.125457	0.0335485	0.0367364	0.0335485	0.0323780	6.927134e-01	0.4937670	9.718185e-01	Luzp2	up
10	BRINP1	BRINP1	-0.3392242	0.1600891	-2.118972	0.0340928	0.0305033	0.0340928	0.0324119	7.123227e-01	0.5204856	9.748658e-01	Brinp1	up
56	KLHDC9	KLHDC9	-0.2353128	0.1106619	-2.126413	0.0334689	0.0371299	0.0334689	0.0330566	7.903236e-01	0.6362230	9.817491e-01	Klhdc9	up
88	PLCB1	PLCB1	-0.6420079	0.3024846	-2.122448	0.0338001	0.0324093	0.0338001	0.0333069	5.262348e-01	0.2908735	9.520392e-01	Plcb1	up
105	SIDT1	SIDT1	-0.4174642	0.1983770	-2.104398	0.0353437	0.0278401	0.0353437	0.0339631	6.587150e-01	0.4465178	9.717541e-01	Sidt1	up
107	SLC1A2	SLC1A2	-0.2124443	0.1003561	-2.116904	0.0342680	0.0375824	0.0342680	0.0340428	8.086053e-01	0.6642221	9.843735e-01	Slc1a2	up
38	EMID1	EMID1	-0.4502308	0.2133506	-2.110287	0.0348337	0.0338802	0.0348337	0.0343860	6.374810e-01	0.4196265	9.684374e-01	Emid1	up
13	CACNA2D4	CACNA2D4	1.0245697	0.4891258	2.094696	0.0361980	0.0427101	0.0361980	0.0350024	2.785896e+00	1.0681207	7.266237e+00	Cacna2d4	up
76	NXPH3	NXPH3	-0.3774392	0.1806948	-2.088822	0.0367238	0.0409742	0.0367238	0.0363733	6.856149e-01	0.4811412	9.769850e-01	Nxph3	up
129	UNC13B	UNC13B	-0.7827685	0.3736143	-2.095125	0.0361599	0.0336327	0.0361599	0.0369294	4.571387e-01	0.2197996	9.507559e-01	Unc13b	up
132	WNT9A	WNT9A	0.6958626	0.3367280	2.066542	0.0387773	0.0463104	0.0387773	0.0378423	2.005438e+00	1.0365397	3.880008e+00	Wnt9a	up
112	SMIM1	SMIM1	0.5206950	0.2527491	2.060126	0.0393865	0.0428917	0.0393865	0.0385225	1.683197e+00	1.0256390	2.762329e+00	Smim1	up
9	BAIAP3	BAIAP3	-0.2794113	0.1351514	-2.067396	0.0386969	0.0418946	0.0386969	0.0390339	7.562288e-01	0.5802460	9.855853e-01	Baiap3	up
33	DMKN	DMKN	-0.3291229	0.1606125	-2.049173	0.0404452	0.0368210	0.0404452	0.0393216	7.195546e-01	0.5252307	9.857741e-01	Dmkn	up
115	SPRY3	SPRY3	0.4960903	0.2418322	2.051382	0.0402298	0.0386226	0.0402298	0.0404007	1.642288e+00	1.0223540	2.638136e+00	Spry3	up
2	ABHD3	ABHD3	0.5955091	0.2929307	2.032935	0.0420591	0.0407117	0.0420591	0.0409840	1.813954e+00	1.0216055	3.220842e+00	Abhd3	up
18	CD5L	CD5L	0.7754014	0.3848963	2.014572	0.0439495	0.1129359	0.0439495	0.0414056	2.171464e+00	1.0212410	4.617181e+00	Cd5l	down
58	LGI3	LGI3	0.1822722	0.0897599	2.030665	0.0422890	0.0443037	0.0422890	0.0414997	1.199941e+00	1.0063663	1.430749e+00	Lgi3	up
99	RSPO3	RSPO3	-0.6746499	0.3363098	-2.006037	0.0448523	0.0301619	0.0448523	0.0427121	5.093347e-01	0.2634728	9.846247e-01	Rspo3	up
32	DCHS2	DCHS2	-1.0486217	0.5210343	-2.012577	0.0441591	0.0349509	0.0441591	0.0427312	3.504204e-01	0.1262072	9.729591e-01	Dchs2	up
35	DNAH12	DNAH12	3.9025793	1.9420087	2.009558	0.0444780	0.0681526	0.0444780	0.0436603	4.953004e+01	1.1011029	2.227971e+03	Dnah12	up
31	CYB561	CYB561	-0.3508557	0.1754585	-1.999651	0.0455380	0.0350770	0.0455380	0.0445372	7.040854e-01	0.4992003	9.930608e-01	Cyb561	up
48	GPR176	GPR176	0.3455603	0.1729604	1.997916	0.0457257	0.0478815	0.0457257	0.0446132	1.412781e+00	1.0065858	1.982892e+00	Gpr176	up
34	DMRTC1	DMRTC1	98.5643120	49.8616264	1.976757	0.0480691	0.0630351	0.0480691	0.0448591	6.396418e+42	2.3101676	1.771047e+85	Dmrtc1a	up
116	SPTBN5	SPTBN5	0.6025659	0.3021065	1.994548	0.0460922	0.0585582	0.0460922	0.0449381	1.826800e+00	1.0105029	3.302513e+00	Sptbn5	up
8	ARPP21	ARPP21	-0.3743726	0.1867061	-2.005144	0.0449477	0.0462126	0.0449477	0.0451881	6.877206e-01	0.4769661	9.916001e-01	Arpp21	up
7	ALDOC	ALDOC	-0.2765491	0.1381129	-2.002341	0.0452480	0.0542366	0.0452480	0.0455496	7.583964e-01	0.5785413	9.941643e-01	Aldoc	up
23	CHST1	CHST1	-0.2144981	0.1081277	-1.983748	0.0472839	0.0521806	0.0472839	0.0467366	8.069463e-01	0.6528391	9.974316e-01	Chst1	up
131	WNT4	WNT4	-0.7042827	0.3598625	-1.957089	0.0503371	0.0247391	0.0503371	0.0469690	4.944631e-01	0.2442409	1.001035e+00	Wnt4	up
20	CDK6	CDK6	0.3824756	0.1938366	1.973185	0.0484744	0.0528413	0.0484744	0.0485995	1.465909e+00	1.0025661	2.143389e+00	Cdk6	down
97	RASGRF1	RASGRF1	-0.2693178	0.1370775	-1.964712	0.0494476	0.0439386	0.0494476	0.0487218	7.639004e-01	0.5839238	9.993493e-01	Rasgrf1	up
4	ADAMTS3	ADAMTS3	1.9769091	0.9586936	2.062086	0.0391995	0.0865033	0.0391995	0.0488657	7.220391e+00	1.1028571	4.727180e+01	Adamts3	up
119	SYT3	SYT3	-0.3410561	0.1739619	-1.960522	0.0499348	0.0391895	0.0499348	0.0489593	7.110190e-01	0.5055971	9.999029e-01	Syt3	up
81	PCDHGA4	PCDHGA4	1.0331251	0.5206786	1.984190	0.0472347	0.0638059	0.0472347	0.0497464	2.809833e+00	1.0126938	7.796199e+00	Pcdhga4	up
63	LSAMP	LSAMP	-0.6089189	0.3110885	-1.957382	0.0503026	0.0520013	0.0503026	0.0499826	5.439386e-01	0.2956316	1.000804e+00	Lsamp	up

IDH_CODEL

Gene-sets considered

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Table genes

	Variable	Term	Beta	StandardError	Z	P	LRT	Wald	LogRank	HR	HRlower	HRupper	mm	status
47	GPR139	GPR139	2.9954716	0.5459944	5.486268	0.0000000	0.0000008	0.0000000	0.0000000	1.999479e+01	6.8574946	5.829993e+01	Gpr139	up
11	BVES	BVES	0.7842063	0.1424517	5.505070	0.0000000	0.0000025	0.0000000	0.0000001	2.190667e+00	1.6569958	2.896220e+00	Bves	up
22	CHIC2	CHIC2	1.1744777	0.2267115	5.180495	0.0000002	0.0000079	0.0000002	0.0000002	3.236452e+00	2.0753531	5.047152e+00	Chic2	down
62	LRRK2	LRRK2	0.6724442	0.1341983	5.010825	0.0000005	0.0000059	0.0000005	0.0000002	1.959020e+00	1.5059447	2.548406e+00	Lrrk2	up
21	CEP135	CEP135	1.1901584	0.2479228	4.800520	0.0000016	0.0000491	0.0000016	0.0000014	3.287602e+00	2.0223064	5.344554e+00	Cep135	down
133	ZBTB8B	ZBTB8B	1.1045218	0.2349319	4.701455	0.0000026	0.0000192	0.0000026	0.0000022	3.017781e+00	1.9042034	4.782579e+00	Zbtb8b	up
86	PI4K2B	PI4K2B	1.0371524	0.2498474	4.151143	0.0000331	0.0015532	0.0000331	0.0000217	2.821172e+00	1.7288568	4.603626e+00	Pi4k2b	down
102	SERINC2	SERINC2	0.6263722	0.1610620	3.889012	0.0001007	0.0002453	0.0001007	0.0000827	1.870811e+00	1.3643749	2.565230e+00	Serinc2	up
104	SH3GL2	SH3GL2	-0.7907620	0.2005988	-3.942008	0.0000808	0.0000695	0.0000808	0.0001115	4.534991e-01	0.3060740	6.719337e-01	Sh3gl2	up
15	CCDC87	CCDC87	-0.7788043	0.2036870	-3.823535	0.0001316	0.0001516	0.0001316	0.0001223	4.589545e-01	0.3078867	6.841452e-01	Ccdc87	up
80	PCDHGA3	PCDHGA3	0.6336887	0.1854916	3.416266	0.0006349	0.0047731	0.0006349	0.0001990	1.884549e+00	1.3101371	2.710805e+00	Pcdhga3	up
101	SEPSECS	SEPSECS	1.0745060	0.2684215	4.003055	0.0000625	0.0004790	0.0000625	0.0002610	2.928546e+00	1.7304985	4.956017e+00	Sepsecs	down
78	PAX5	PAX5	4.3732708	1.3013911	3.360458	0.0007781	0.0111408	0.0007781	0.0002911	7.930259e+01	6.1878707	1.016327e+03	Pax5	down
54	KCNG1	KCNG1	-0.5347163	0.1540201	-3.471731	0.0005171	0.0001938	0.0005171	0.0004520	5.858355e-01	0.4331851	7.922784e-01	Kcng1	up
85	PHKG1	PHKG1	-0.3998301	0.1165522	-3.430480	0.0006025	0.0009269	0.0006025	0.0004617	6.704339e-01	0.5335149	8.424913e-01	Phkg1	up
50	HHIP	HHIP	0.5367070	0.1575686	3.406179	0.0006588	0.0014311	0.0006588	0.0005304	1.710365e+00	1.2559323	2.329225e+00	Hhip	up
36	EFCAB6	EFCAB6	-7.0065194	2.0604116	-3.400543	0.0006725	0.0002490	0.0006725	0.0005886	9.060000e-04	0.0000160	5.139640e-02	Efcab6	up
68	METTL11B	METTL11B	2.6216611	0.8373169	3.131026	0.0017420	0.0097680	0.0017420	0.0007621	1.375856e+01	2.6659224	7.100655e+01	Mettl11b	up
89	PLCXD1	PLCXD1	0.6979770	0.2051305	3.402601	0.0006675	0.0009493	0.0006675	0.0007977	2.009683e+00	1.3443743	3.004242e+00	Plcxd1	up
25	CLEC18A	CLEC18A	2.0090652	0.6175386	3.253344	0.0011406	0.0037224	0.0011406	0.0009366	7.456344e+00	2.2226761	2.501357e+01	Clec18a	up
82	PCDHGA8	PCDHGA8	4.5064285	1.4663795	3.073167	0.0021180	0.0114419	0.0021180	0.0016940	9.059767e+01	5.1160230	1.604359e+03	Pcdhga8	up
79	PCDH7	PCDH7	-0.7147787	0.2368258	-3.018163	0.0025431	0.0019136	0.0025431	0.0024481	4.893004e-01	0.3076020	7.783268e-01	Pcdh7	up
17	CCNB2	CCNB2	0.3221457	0.1089420	2.957039	0.0031061	0.0046368	0.0031061	0.0027830	1.380086e+00	1.1147424	1.708589e+00	Ccnb2	down
1	ABCA8	ABCA8	0.4256288	0.1413422	3.011336	0.0026010	0.0059862	0.0026010	0.0030725	1.530552e+00	1.1602125	2.019105e+00	Abca8b	up
43	GDF10	GDF10	-0.3061819	0.1055962	-2.899555	0.0037369	0.0022250	0.0037369	0.0032660	7.362527e-01	0.5986090	9.055460e-01	Gdf10	up
44	GJA1	GJA1	-0.4050831	0.1380017	-2.935349	0.0033317	0.0035724	0.0033317	0.0034714	6.669214e-01	0.5088706	8.740613e-01	Gja1	up
29	CRTAC1	CRTAC1	-0.5539521	0.1912721	-2.896147	0.0037778	0.0040257	0.0037778	0.0037843	5.746742e-01	0.3950123	8.360510e-01	Crtac1	up
74	NRG3	NRG3	-2.4032161	0.8375289	-2.869413	0.0041123	0.0031459	0.0041123	0.0039243	9.042670e-02	0.0175142	4.668770e-01	Nrg3	up
123	TPSAB1	TPSAB1	-0.7426437	0.2748043	-2.702446	0.0068831	0.0004653	0.0068831	0.0039419	4.758542e-01	0.2776899	8.154320e-01	Tpsb2	down
128	TUB	TUB	-0.5196510	0.1808249	-2.873780	0.0040559	0.0047320	0.0040559	0.0041056	5.947281e-01	0.4172535	8.476897e-01	Tub	up
103	SFTPC	SFTPC	0.4223342	0.1487355	2.839498	0.0045185	0.0058762	0.0045185	0.0041667	1.525518e+00	1.1397603	2.041838e+00	Sftpc	up
120	TCHH	TCHH	-0.5988549	0.2142769	-2.794771	0.0051936	0.0025865	0.0051936	0.0050215	5.494404e-01	0.3610171	8.362064e-01	Tchh	up
130	VWC2	VWC2	-0.8118496	0.2985573	-2.719242	0.0065432	0.0042834	0.0065432	0.0057806	4.440360e-01	0.2473351	7.971695e-01	Vwc2	up
27	CNGA4	CNGA4	-1.0359853	0.3821171	-2.711172	0.0067046	0.0040296	0.0067046	0.0063590	3.548765e-01	0.1678103	7.504746e-01	Cnga4	up
114	SPHKAP	SPHKAP	-0.4625777	0.1721975	-2.686321	0.0072244	0.0065275	0.0072244	0.0068047	6.296585e-01	0.4492936	8.824291e-01	Sphkap	up
46	GLT8D2	GLT8D2	-1.6440659	0.6170412	-2.664435	0.0077118	0.0045787	0.0077118	0.0071151	1.931929e-01	0.0576454	6.474670e-01	Glt8d2	up
40	FAM186B	FAM186B	2.7648858	1.0270985	2.691938	0.0071038	0.0102688	0.0071038	0.0071928	1.587723e+01	2.1208349	1.188618e+02	Fam186b	up
5	ADCY2	ADCY2	-0.5091532	0.1915128	-2.658586	0.0078469	0.0086014	0.0078469	0.0075234	6.010043e-01	0.4129159	8.747693e-01	Adcy2	up
87	PLA2G4E	PLA2G4E	19.0823473	7.2463960	2.633357	0.0084545	0.0379296	0.0084545	0.0081310	1.938019e+08	131.5875091	2.854313e+14	Pla2g4e	up
96	RAB42	RAB42	0.5038644	0.1915025	2.631111	0.0085106	0.0086515	0.0085106	0.0084776	1.655105e+00	1.1371513	2.408978e+00	Rab42	up
73	NR3C2	NR3C2	-1.1889369	0.4523989	-2.628072	0.0085870	0.0066070	0.0085870	0.0085969	3.045449e-01	0.1254783	7.391523e-01	Nr3c2	up
60	LRRC18	LRRC18	0.8248612	0.3172093	2.600369	0.0093124	0.0202333	0.0093124	0.0094480	2.281564e+00	1.2252469	4.248560e+00	Lrrc18	up
66	MAP6D1	MAP6D1	0.3520670	0.1365555	2.578198	0.0099317	0.0104100	0.0099317	0.0094586	1.422004e+00	1.0880893	1.858390e+00	Map6d1	up
69	MGAT4C	MGAT4C	-1.3821722	0.5241332	-2.637063	0.0083627	0.0040005	0.0083627	0.0095399	2.510327e-01	0.0898643	7.012506e-01	Mgat4c	up
106	SLAIN2	SLAIN2	0.8455718	0.3292619	2.568083	0.0102263	0.0111327	0.0102263	0.0096223	2.329309e+00	1.2216841	4.441149e+00	Slain2	down
113	SPAG17	SPAG17	10.0872014	4.2371258	2.380671	0.0172812	0.0574988	0.0172812	0.0110288	2.403344e+04	5.9452191	9.715474e+07	Spag17	up
37	EFEMP1	EFEMP1	-0.2914440	0.1149583	-2.535214	0.0112379	0.0122232	0.0112379	0.0111204	7.471839e-01	0.5964510	9.360093e-01	Efemp1	up
12	CACNA2D2	CACNA2D2	-0.8043295	0.3205444	-2.509261	0.0120984	0.0098839	0.0120984	0.0118147	4.473878e-01	0.2386911	8.385559e-01	Cacna2d2	up
55	KLF14	KLF14	1.6071670	0.6370812	2.522703	0.0116457	0.0346226	0.0116457	0.0119965	4.988658e+00	1.4311964	1.738875e+01	Klf14	up
127	TTLL7	TTLL7	0.4510948	0.1808449	2.494374	0.0126179	0.0140847	0.0126179	0.0121624	1.570030e+00	1.1014697	2.237914e+00	Ttll7	up
28	CPA3	CPA3	-2.6676371	1.2839007	-2.077760	0.0377315	0.0010779	0.0377315	0.0122039	6.941610e-02	0.0056053	8.596431e-01	Cpa3	down
94	PRIMA1	PRIMA1	0.6222890	0.2488279	2.500881	0.0123885	0.0134312	0.0123885	0.0122378	1.863188e+00	1.1440737	3.034306e+00	Prima1	up
110	SLC7A11	SLC7A11	-0.5173928	0.2068672	-2.501087	0.0123813	0.0111473	0.0123813	0.0128561	5.960726e-01	0.3973869	8.940974e-01	Slc7a11	up
83	PDGFRA	PDGFRA	0.3197732	0.1282574	2.493214	0.0126593	0.0114151	0.0126593	0.0129613	1.376815e+00	1.0707863	1.770307e+00	Pdgfra	down
65	MAGEE2	MAGEE2	0.2072085	0.0847911	2.443752	0.0145354	0.0121291	0.0145354	0.0129998	1.230239e+00	1.0418739	1.452659e+00	Magee2	up
26	CLMN	CLMN	0.5914685	0.2374123	2.491314	0.0127272	0.0186262	0.0127272	0.0131366	1.806639e+00	1.1344511	2.877115e+00	Clmn	up
93	PPP2R2B	PPP2R2B	-0.7571162	0.3070699	-2.465615	0.0136778	0.0122080	0.0136778	0.0135049	4.690170e-01	0.2569273	8.561837e-01	Ppp2r2b	up
70	MSR1	MSR1	0.6293928	0.2584362	2.435390	0.0148758	0.0257520	0.0148758	0.0144026	1.876471e+00	1.1307343	3.114032e+00	Msr1	down
16	CCL27	CCL27	-10.1807420	4.9394362	-2.061114	0.0392921	0.0011244	0.0392921	0.0147958	3.790000e-05	0.0000000	6.067582e-01	Ccl27a	up
111	SLITRK5	SLITRK5	-0.4852339	0.1987193	-2.441806	0.0146140	0.0166802	0.0146140	0.0148097	6.155532e-01	0.4169802	9.086900e-01	Slitrk5	up
121	TFCP2L1	TFCP2L1	0.4640884	0.1932673	2.401277	0.0163379	0.0254705	0.0163379	0.0148488	1.590564e+00	1.0890344	2.323060e+00	Tfcp2l1	up
100	SCUBE3	SCUBE3	0.5114631	0.2125001	2.406884	0.0160893	0.0256815	0.0160893	0.0148709	1.667729e+00	1.0996264	2.529333e+00	Scube3	up
134	ZCCHC3	ZCCHC3	0.8449587	0.3501292	2.413277	0.0158098	0.0144719	0.0158098	0.0157013	2.327882e+00	1.1720075	4.623719e+00	Zcchc3	up
6	AHCYL2	AHCYL2	-0.4618186	0.1916865	-2.409239	0.0159858	0.0144949	0.0159858	0.0157534	6.301366e-01	0.4327837	9.174842e-01	Ahcyl2	up
84	PELI3	PELI3	-0.5361502	0.2219673	-2.415447	0.0157159	0.0125532	0.0157159	0.0158807	5.849960e-01	0.3786292	9.038405e-01	Peli3	up
117	SYT12	SYT12	-0.3974626	0.1658915	-2.395919	0.0165787	0.0103877	0.0165787	0.0161174	6.720231e-01	0.4854864	9.302320e-01	Syt12	up
61	LRRC6	LRRC6	-1.2100537	0.5083194	-2.380499	0.0172892	0.0148202	0.0172892	0.0162693	2.981813e-01	0.1101027	8.075373e-01	Lrrc6	up
77	OSR1	OSR1	0.2144682	0.0905432	2.368683	0.0178516	0.0251440	0.0178516	0.0166777	1.239203e+00	1.0377000	1.479834e+00	Osr1	up
90	PLK5	PLK5	-0.5414021	0.2291631	-2.362518	0.0181512	0.0166165	0.0181512	0.0175387	5.819318e-01	0.3713711	9.118766e-01	Plk5	up
59	LIX1	LIX1	-0.2840070	0.1205932	-2.355083	0.0185186	0.0237242	0.0185186	0.0177018	7.527614e-01	0.5943034	9.534687e-01	Lix1	up
45	GLRA3	GLRA3	-0.6180356	0.2634646	-2.345801	0.0189862	0.0133041	0.0189862	0.0185040	5.390022e-01	0.3216097	9.033416e-01	Glra3	up
71	NIPAL3	NIPAL3	0.3068599	0.1315510	2.332631	0.0196675	0.0202769	0.0196675	0.0189767	1.359150e+00	1.0502462	1.758911e+00	Nipal3	up
75	NSUN7	NSUN7	2.8988354	1.2476243	2.323484	0.0201532	0.0274793	0.0201532	0.0194083	1.815299e+01	1.5738687	2.093765e+02	Nsun7	up
3	ABLIM3	ABLIM3	-0.4204272	0.1804536	-2.329836	0.0198148	0.0196918	0.0198148	0.0196757	6.567662e-01	0.4611141	9.354340e-01	Ablim3	up
98	RNF32	RNF32	-0.7549155	0.3244026	-2.327095	0.0199602	0.0195812	0.0199602	0.0197767	4.700503e-01	0.2488928	8.877207e-01	Rnf32	up
30	CRYBB1	CRYBB1	-0.6109657	0.2598025	-2.351655	0.0186901	0.0162412	0.0186901	0.0199216	5.428264e-01	0.3262246	9.032443e-01	Crybb1	up
122	TNNI1	TNNI1	2.8923203	1.3335905	2.168822	0.0300962	0.0799377	0.0300962	0.0199732	1.803511e+01	1.3211876	2.461915e+02	Tnni1	up
91	POPDC3	POPDC3	0.3123546	0.1361879	2.293555	0.0218161	0.0284385	0.0218161	0.0201892	1.366639e+00	1.0464789	1.784749e+00	Popdc3	up
14	CAMSAP3	CAMSAP3	-0.2662145	0.1163447	-2.288152	0.0221286	0.0232764	0.0221286	0.0215514	7.662747e-01	0.6100307	9.625368e-01	Camsap3	up
42	FZD2	FZD2	0.3875964	0.1688566	2.295418	0.0217092	0.0214499	0.0217092	0.0216465	1.473435e+00	1.0582785	2.051455e+00	Fzd2	up
135	ZCCHC4	ZCCHC4	0.7571164	0.3109674	2.434713	0.0149036	0.0324878	0.0149036	0.0221649	2.132119e+00	1.1590857	3.921998e+00	Zcchc4	down
124	TPSB2	TPSB2	-0.4678065	0.2090684	-2.237576	0.0252487	0.0102559	0.0252487	0.0225107	6.263747e-01	0.4157908	9.436123e-01	Tpsb2	down
109	SLC4A4	SLC4A4	-0.4141597	0.1824616	-2.269846	0.0232169	0.0246088	0.0232169	0.0226269	6.608954e-01	0.4621906	9.450271e-01	Slc4a4	up
52	HTR2C	HTR2C	-3.1565775	1.3995778	-2.255378	0.0241096	0.0133067	0.0241096	0.0232918	4.257120e-02	0.0027403	6.613610e-01	Htr2c	up
108	SLC35F4	SLC35F4	6.9660928	3.4145385	2.040127	0.0413377	0.1207829	0.0413377	0.0234941	1.060073e+03	1.3148471	8.546653e+05	Slc35f4	up
39	FAM111A	FAM111A	0.4931808	0.2189509	2.252472	0.0242925	0.0261799	0.0242925	0.0238429	1.637517e+00	1.0661403	2.515110e+00	Fam111a	down
118	SYT17	SYT17	-0.6691720	0.2974328	-2.249826	0.0244600	0.0230309	0.0244600	0.0240354	5.121324e-01	0.2858953	9.173975e-01	Syt17	up
95	PROK2	PROK2	1.8148931	0.8212733	2.209853	0.0271154	0.0412250	0.0271154	0.0258169	6.140420e+00	1.2278037	3.070911e+01	Prok2	up
136	ZNF519	ZNF519	0.7099944	0.3196717	2.221011	0.0263502	0.0282681	0.0263502	0.0258965	2.033980e+00	1.0870303	3.805850e+00	Zfp941	up
92	PPIL6	PPIL6	-0.8190445	0.3663250	-2.235841	0.0253622	0.0228182	0.0253622	0.0262949	4.408527e-01	0.2150191	9.038782e-01	Ppil6	up
67	MEIG1	MEIG1	-1.4153405	0.6416480	-2.205790	0.0273987	0.0165410	0.0273987	0.0263250	2.428429e-01	0.0690484	8.540773e-01	Meig1	up
41	FRY	FRY	-0.6736747	0.3074954	-2.190845	0.0284630	0.0283663	0.0284630	0.0281425	5.098316e-01	0.2790527	9.314667e-01	Fry	up
24	CHST15	CHST15	-0.4167445	0.1902333	-2.190702	0.0284734	0.0278526	0.0284734	0.0281733	6.591893e-01	0.4540287	9.570553e-01	Chst15	up
19	CDH7	CDH7	-0.6616486	0.3054743	-2.165971	0.0303134	0.0216067	0.0303134	0.0286263	5.160000e-01	0.2835499	9.390093e-01	Cdh7	up
57	KNDC1	KNDC1	-0.2969632	0.1366881	-2.172560	0.0298134	0.0279141	0.0298134	0.0293196	7.430714e-01	0.5684358	9.713588e-01	Kndc1	up
125	TTC34	TTC34	-3.7733836	1.7457180	-2.161508	0.0306561	0.0235946	0.0306561	0.0297951	2.297420e-02	0.0007504	7.033933e-01	Ttc34	up
49	HHATL	HHATL	0.2470745	0.1144943	2.157963	0.0309307	0.0303280	0.0309307	0.0308650	1.280274e+00	1.0229287	1.602363e+00	Hhatl	up
53	KCNB1	KCNB1	-0.4829054	0.2251743	-2.144585	0.0319861	0.0281475	0.0319861	0.0316609	6.169882e-01	0.3968333	9.592804e-01	Kcnb1	up
51	HS6ST2	HS6ST2	0.8537621	0.4008883	2.129676	0.0331984	0.0357143	0.0331984	0.0317125	2.348466e+00	1.0704032	5.152535e+00	Hs6st2	up
126	TTLL11	TTLL11	1.3664702	0.6377193	2.142745	0.0321335	0.0412975	0.0321335	0.0321406	3.921484e+00	1.1236286	1.368605e+01	Ttll11	up
72	NLRP6	NLRP6	0.5442128	0.2548265	2.135621	0.0327103	0.0448962	0.0327103	0.0322133	1.723251e+00	1.0457789	2.839601e+00	Nlrp6	up
64	LUZP2	LUZP2	-0.3671389	0.1727341	-2.125457	0.0335485	0.0367364	0.0335485	0.0323780	6.927134e-01	0.4937670	9.718185e-01	Luzp2	up
10	BRINP1	BRINP1	-0.3392242	0.1600891	-2.118972	0.0340928	0.0305033	0.0340928	0.0324119	7.123227e-01	0.5204856	9.748658e-01	Brinp1	up
56	KLHDC9	KLHDC9	-0.2353128	0.1106619	-2.126413	0.0334689	0.0371299	0.0334689	0.0330566	7.903236e-01	0.6362230	9.817491e-01	Klhdc9	up
88	PLCB1	PLCB1	-0.6420079	0.3024846	-2.122448	0.0338001	0.0324093	0.0338001	0.0333069	5.262348e-01	0.2908735	9.520392e-01	Plcb1	up
105	SIDT1	SIDT1	-0.4174642	0.1983770	-2.104398	0.0353437	0.0278401	0.0353437	0.0339631	6.587150e-01	0.4465178	9.717541e-01	Sidt1	up
107	SLC1A2	SLC1A2	-0.2124443	0.1003561	-2.116904	0.0342680	0.0375824	0.0342680	0.0340428	8.086053e-01	0.6642221	9.843735e-01	Slc1a2	up
38	EMID1	EMID1	-0.4502308	0.2133506	-2.110287	0.0348337	0.0338802	0.0348337	0.0343860	6.374810e-01	0.4196265	9.684374e-01	Emid1	up
13	CACNA2D4	CACNA2D4	1.0245697	0.4891258	2.094696	0.0361980	0.0427101	0.0361980	0.0350024	2.785896e+00	1.0681207	7.266237e+00	Cacna2d4	up
76	NXPH3	NXPH3	-0.3774392	0.1806948	-2.088822	0.0367238	0.0409742	0.0367238	0.0363733	6.856149e-01	0.4811412	9.769850e-01	Nxph3	up
129	UNC13B	UNC13B	-0.7827685	0.3736143	-2.095125	0.0361599	0.0336327	0.0361599	0.0369294	4.571387e-01	0.2197996	9.507559e-01	Unc13b	up
132	WNT9A	WNT9A	0.6958626	0.3367280	2.066542	0.0387773	0.0463104	0.0387773	0.0378423	2.005438e+00	1.0365397	3.880008e+00	Wnt9a	up
112	SMIM1	SMIM1	0.5206950	0.2527491	2.060126	0.0393865	0.0428917	0.0393865	0.0385225	1.683197e+00	1.0256390	2.762329e+00	Smim1	up
9	BAIAP3	BAIAP3	-0.2794113	0.1351514	-2.067396	0.0386969	0.0418946	0.0386969	0.0390339	7.562288e-01	0.5802460	9.855853e-01	Baiap3	up
33	DMKN	DMKN	-0.3291229	0.1606125	-2.049173	0.0404452	0.0368210	0.0404452	0.0393216	7.195546e-01	0.5252307	9.857741e-01	Dmkn	up
115	SPRY3	SPRY3	0.4960903	0.2418322	2.051382	0.0402298	0.0386226	0.0402298	0.0404007	1.642288e+00	1.0223540	2.638136e+00	Spry3	up
2	ABHD3	ABHD3	0.5955091	0.2929307	2.032935	0.0420591	0.0407117	0.0420591	0.0409840	1.813954e+00	1.0216055	3.220842e+00	Abhd3	up
18	CD5L	CD5L	0.7754014	0.3848963	2.014572	0.0439495	0.1129359	0.0439495	0.0414056	2.171464e+00	1.0212410	4.617181e+00	Cd5l	down
58	LGI3	LGI3	0.1822722	0.0897599	2.030665	0.0422890	0.0443037	0.0422890	0.0414997	1.199941e+00	1.0063663	1.430749e+00	Lgi3	up
99	RSPO3	RSPO3	-0.6746499	0.3363098	-2.006037	0.0448523	0.0301619	0.0448523	0.0427121	5.093347e-01	0.2634728	9.846247e-01	Rspo3	up
32	DCHS2	DCHS2	-1.0486217	0.5210343	-2.012577	0.0441591	0.0349509	0.0441591	0.0427312	3.504204e-01	0.1262072	9.729591e-01	Dchs2	up
35	DNAH12	DNAH12	3.9025793	1.9420087	2.009558	0.0444780	0.0681526	0.0444780	0.0436603	4.953004e+01	1.1011029	2.227971e+03	Dnah12	up
31	CYB561	CYB561	-0.3508557	0.1754585	-1.999651	0.0455380	0.0350770	0.0455380	0.0445372	7.040854e-01	0.4992003	9.930608e-01	Cyb561	up
48	GPR176	GPR176	0.3455603	0.1729604	1.997916	0.0457257	0.0478815	0.0457257	0.0446132	1.412781e+00	1.0065858	1.982892e+00	Gpr176	up
34	DMRTC1	DMRTC1	98.5643120	49.8616264	1.976757	0.0480691	0.0630351	0.0480691	0.0448591	6.396418e+42	2.3101676	1.771047e+85	Dmrtc1a	up
116	SPTBN5	SPTBN5	0.6025659	0.3021065	1.994548	0.0460922	0.0585582	0.0460922	0.0449381	1.826800e+00	1.0105029	3.302513e+00	Sptbn5	up
8	ARPP21	ARPP21	-0.3743726	0.1867061	-2.005144	0.0449477	0.0462126	0.0449477	0.0451881	6.877206e-01	0.4769661	9.916001e-01	Arpp21	up
7	ALDOC	ALDOC	-0.2765491	0.1381129	-2.002341	0.0452480	0.0542366	0.0452480	0.0455496	7.583964e-01	0.5785413	9.941643e-01	Aldoc	up
23	CHST1	CHST1	-0.2144981	0.1081277	-1.983748	0.0472839	0.0521806	0.0472839	0.0467366	8.069463e-01	0.6528391	9.974316e-01	Chst1	up
131	WNT4	WNT4	-0.7042827	0.3598625	-1.957089	0.0503371	0.0247391	0.0503371	0.0469690	4.944631e-01	0.2442409	1.001035e+00	Wnt4	up
20	CDK6	CDK6	0.3824756	0.1938366	1.973185	0.0484744	0.0528413	0.0484744	0.0485995	1.465909e+00	1.0025661	2.143389e+00	Cdk6	down
97	RASGRF1	RASGRF1	-0.2693178	0.1370775	-1.964712	0.0494476	0.0439386	0.0494476	0.0487218	7.639004e-01	0.5839238	9.993493e-01	Rasgrf1	up
4	ADAMTS3	ADAMTS3	1.9769091	0.9586936	2.062086	0.0391995	0.0865033	0.0391995	0.0488657	7.220391e+00	1.1028571	4.727180e+01	Adamts3	up
119	SYT3	SYT3	-0.3410561	0.1739619	-1.960522	0.0499348	0.0391895	0.0499348	0.0489593	7.110190e-01	0.5055971	9.999029e-01	Syt3	up
81	PCDHGA4	PCDHGA4	1.0331251	0.5206786	1.984190	0.0472347	0.0638059	0.0472347	0.0497464	2.809833e+00	1.0126938	7.796199e+00	Pcdhga4	up
63	LSAMP	LSAMP	-0.6089189	0.3110885	-1.957382	0.0503026	0.0520013	0.0503026	0.0499826	5.439386e-01	0.2956316	1.000804e+00	Lsamp	up

IDH_NOCODEL

Gene-sets considered

UP and DOWN

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Table genes

	Variable	Term	Beta	StandardError	Z	P	LRT	Wald	LogRank	HR	HRlower	HRupper	mm	status
47	GPR139	GPR139	2.9954716	0.5459944	5.486268	0.0000000	0.0000008	0.0000000	0.0000000	1.999479e+01	6.8574946	5.829993e+01	Gpr139	up
11	BVES	BVES	0.7842063	0.1424517	5.505070	0.0000000	0.0000025	0.0000000	0.0000001	2.190667e+00	1.6569958	2.896220e+00	Bves	up
22	CHIC2	CHIC2	1.1744777	0.2267115	5.180495	0.0000002	0.0000079	0.0000002	0.0000002	3.236452e+00	2.0753531	5.047152e+00	Chic2	down
62	LRRK2	LRRK2	0.6724442	0.1341983	5.010825	0.0000005	0.0000059	0.0000005	0.0000002	1.959020e+00	1.5059447	2.548406e+00	Lrrk2	up
21	CEP135	CEP135	1.1901584	0.2479228	4.800520	0.0000016	0.0000491	0.0000016	0.0000014	3.287602e+00	2.0223064	5.344554e+00	Cep135	down
133	ZBTB8B	ZBTB8B	1.1045218	0.2349319	4.701455	0.0000026	0.0000192	0.0000026	0.0000022	3.017781e+00	1.9042034	4.782579e+00	Zbtb8b	up
86	PI4K2B	PI4K2B	1.0371524	0.2498474	4.151143	0.0000331	0.0015532	0.0000331	0.0000217	2.821172e+00	1.7288568	4.603626e+00	Pi4k2b	down
102	SERINC2	SERINC2	0.6263722	0.1610620	3.889012	0.0001007	0.0002453	0.0001007	0.0000827	1.870811e+00	1.3643749	2.565230e+00	Serinc2	up
104	SH3GL2	SH3GL2	-0.7907620	0.2005988	-3.942008	0.0000808	0.0000695	0.0000808	0.0001115	4.534991e-01	0.3060740	6.719337e-01	Sh3gl2	up
15	CCDC87	CCDC87	-0.7788043	0.2036870	-3.823535	0.0001316	0.0001516	0.0001316	0.0001223	4.589545e-01	0.3078867	6.841452e-01	Ccdc87	up
80	PCDHGA3	PCDHGA3	0.6336887	0.1854916	3.416266	0.0006349	0.0047731	0.0006349	0.0001990	1.884549e+00	1.3101371	2.710805e+00	Pcdhga3	up
101	SEPSECS	SEPSECS	1.0745060	0.2684215	4.003055	0.0000625	0.0004790	0.0000625	0.0002610	2.928546e+00	1.7304985	4.956017e+00	Sepsecs	down
78	PAX5	PAX5	4.3732708	1.3013911	3.360458	0.0007781	0.0111408	0.0007781	0.0002911	7.930259e+01	6.1878707	1.016327e+03	Pax5	down
54	KCNG1	KCNG1	-0.5347163	0.1540201	-3.471731	0.0005171	0.0001938	0.0005171	0.0004520	5.858355e-01	0.4331851	7.922784e-01	Kcng1	up
85	PHKG1	PHKG1	-0.3998301	0.1165522	-3.430480	0.0006025	0.0009269	0.0006025	0.0004617	6.704339e-01	0.5335149	8.424913e-01	Phkg1	up
50	HHIP	HHIP	0.5367070	0.1575686	3.406179	0.0006588	0.0014311	0.0006588	0.0005304	1.710365e+00	1.2559323	2.329225e+00	Hhip	up
36	EFCAB6	EFCAB6	-7.0065194	2.0604116	-3.400543	0.0006725	0.0002490	0.0006725	0.0005886	9.060000e-04	0.0000160	5.139640e-02	Efcab6	up
68	METTL11B	METTL11B	2.6216611	0.8373169	3.131026	0.0017420	0.0097680	0.0017420	0.0007621	1.375856e+01	2.6659224	7.100655e+01	Mettl11b	up
89	PLCXD1	PLCXD1	0.6979770	0.2051305	3.402601	0.0006675	0.0009493	0.0006675	0.0007977	2.009683e+00	1.3443743	3.004242e+00	Plcxd1	up
25	CLEC18A	CLEC18A	2.0090652	0.6175386	3.253344	0.0011406	0.0037224	0.0011406	0.0009366	7.456344e+00	2.2226761	2.501357e+01	Clec18a	up
82	PCDHGA8	PCDHGA8	4.5064285	1.4663795	3.073167	0.0021180	0.0114419	0.0021180	0.0016940	9.059767e+01	5.1160230	1.604359e+03	Pcdhga8	up
79	PCDH7	PCDH7	-0.7147787	0.2368258	-3.018163	0.0025431	0.0019136	0.0025431	0.0024481	4.893004e-01	0.3076020	7.783268e-01	Pcdh7	up
17	CCNB2	CCNB2	0.3221457	0.1089420	2.957039	0.0031061	0.0046368	0.0031061	0.0027830	1.380086e+00	1.1147424	1.708589e+00	Ccnb2	down
1	ABCA8	ABCA8	0.4256288	0.1413422	3.011336	0.0026010	0.0059862	0.0026010	0.0030725	1.530552e+00	1.1602125	2.019105e+00	Abca8b	up
43	GDF10	GDF10	-0.3061819	0.1055962	-2.899555	0.0037369	0.0022250	0.0037369	0.0032660	7.362527e-01	0.5986090	9.055460e-01	Gdf10	up
44	GJA1	GJA1	-0.4050831	0.1380017	-2.935349	0.0033317	0.0035724	0.0033317	0.0034714	6.669214e-01	0.5088706	8.740613e-01	Gja1	up
29	CRTAC1	CRTAC1	-0.5539521	0.1912721	-2.896147	0.0037778	0.0040257	0.0037778	0.0037843	5.746742e-01	0.3950123	8.360510e-01	Crtac1	up
74	NRG3	NRG3	-2.4032161	0.8375289	-2.869413	0.0041123	0.0031459	0.0041123	0.0039243	9.042670e-02	0.0175142	4.668770e-01	Nrg3	up
123	TPSAB1	TPSAB1	-0.7426437	0.2748043	-2.702446	0.0068831	0.0004653	0.0068831	0.0039419	4.758542e-01	0.2776899	8.154320e-01	Tpsb2	down
128	TUB	TUB	-0.5196510	0.1808249	-2.873780	0.0040559	0.0047320	0.0040559	0.0041056	5.947281e-01	0.4172535	8.476897e-01	Tub	up
103	SFTPC	SFTPC	0.4223342	0.1487355	2.839498	0.0045185	0.0058762	0.0045185	0.0041667	1.525518e+00	1.1397603	2.041838e+00	Sftpc	up
120	TCHH	TCHH	-0.5988549	0.2142769	-2.794771	0.0051936	0.0025865	0.0051936	0.0050215	5.494404e-01	0.3610171	8.362064e-01	Tchh	up
130	VWC2	VWC2	-0.8118496	0.2985573	-2.719242	0.0065432	0.0042834	0.0065432	0.0057806	4.440360e-01	0.2473351	7.971695e-01	Vwc2	up
27	CNGA4	CNGA4	-1.0359853	0.3821171	-2.711172	0.0067046	0.0040296	0.0067046	0.0063590	3.548765e-01	0.1678103	7.504746e-01	Cnga4	up
114	SPHKAP	SPHKAP	-0.4625777	0.1721975	-2.686321	0.0072244	0.0065275	0.0072244	0.0068047	6.296585e-01	0.4492936	8.824291e-01	Sphkap	up
46	GLT8D2	GLT8D2	-1.6440659	0.6170412	-2.664435	0.0077118	0.0045787	0.0077118	0.0071151	1.931929e-01	0.0576454	6.474670e-01	Glt8d2	up
40	FAM186B	FAM186B	2.7648858	1.0270985	2.691938	0.0071038	0.0102688	0.0071038	0.0071928	1.587723e+01	2.1208349	1.188618e+02	Fam186b	up
5	ADCY2	ADCY2	-0.5091532	0.1915128	-2.658586	0.0078469	0.0086014	0.0078469	0.0075234	6.010043e-01	0.4129159	8.747693e-01	Adcy2	up
87	PLA2G4E	PLA2G4E	19.0823473	7.2463960	2.633357	0.0084545	0.0379296	0.0084545	0.0081310	1.938019e+08	131.5875091	2.854313e+14	Pla2g4e	up
96	RAB42	RAB42	0.5038644	0.1915025	2.631111	0.0085106	0.0086515	0.0085106	0.0084776	1.655105e+00	1.1371513	2.408978e+00	Rab42	up
73	NR3C2	NR3C2	-1.1889369	0.4523989	-2.628072	0.0085870	0.0066070	0.0085870	0.0085969	3.045449e-01	0.1254783	7.391523e-01	Nr3c2	up
60	LRRC18	LRRC18	0.8248612	0.3172093	2.600369	0.0093124	0.0202333	0.0093124	0.0094480	2.281564e+00	1.2252469	4.248560e+00	Lrrc18	up
66	MAP6D1	MAP6D1	0.3520670	0.1365555	2.578198	0.0099317	0.0104100	0.0099317	0.0094586	1.422004e+00	1.0880893	1.858390e+00	Map6d1	up
69	MGAT4C	MGAT4C	-1.3821722	0.5241332	-2.637063	0.0083627	0.0040005	0.0083627	0.0095399	2.510327e-01	0.0898643	7.012506e-01	Mgat4c	up
106	SLAIN2	SLAIN2	0.8455718	0.3292619	2.568083	0.0102263	0.0111327	0.0102263	0.0096223	2.329309e+00	1.2216841	4.441149e+00	Slain2	down
113	SPAG17	SPAG17	10.0872014	4.2371258	2.380671	0.0172812	0.0574988	0.0172812	0.0110288	2.403344e+04	5.9452191	9.715474e+07	Spag17	up
37	EFEMP1	EFEMP1	-0.2914440	0.1149583	-2.535214	0.0112379	0.0122232	0.0112379	0.0111204	7.471839e-01	0.5964510	9.360093e-01	Efemp1	up
12	CACNA2D2	CACNA2D2	-0.8043295	0.3205444	-2.509261	0.0120984	0.0098839	0.0120984	0.0118147	4.473878e-01	0.2386911	8.385559e-01	Cacna2d2	up
55	KLF14	KLF14	1.6071670	0.6370812	2.522703	0.0116457	0.0346226	0.0116457	0.0119965	4.988658e+00	1.4311964	1.738875e+01	Klf14	up
127	TTLL7	TTLL7	0.4510948	0.1808449	2.494374	0.0126179	0.0140847	0.0126179	0.0121624	1.570030e+00	1.1014697	2.237914e+00	Ttll7	up
28	CPA3	CPA3	-2.6676371	1.2839007	-2.077760	0.0377315	0.0010779	0.0377315	0.0122039	6.941610e-02	0.0056053	8.596431e-01	Cpa3	down
94	PRIMA1	PRIMA1	0.6222890	0.2488279	2.500881	0.0123885	0.0134312	0.0123885	0.0122378	1.863188e+00	1.1440737	3.034306e+00	Prima1	up
110	SLC7A11	SLC7A11	-0.5173928	0.2068672	-2.501087	0.0123813	0.0111473	0.0123813	0.0128561	5.960726e-01	0.3973869	8.940974e-01	Slc7a11	up
83	PDGFRA	PDGFRA	0.3197732	0.1282574	2.493214	0.0126593	0.0114151	0.0126593	0.0129613	1.376815e+00	1.0707863	1.770307e+00	Pdgfra	down
65	MAGEE2	MAGEE2	0.2072085	0.0847911	2.443752	0.0145354	0.0121291	0.0145354	0.0129998	1.230239e+00	1.0418739	1.452659e+00	Magee2	up
26	CLMN	CLMN	0.5914685	0.2374123	2.491314	0.0127272	0.0186262	0.0127272	0.0131366	1.806639e+00	1.1344511	2.877115e+00	Clmn	up
93	PPP2R2B	PPP2R2B	-0.7571162	0.3070699	-2.465615	0.0136778	0.0122080	0.0136778	0.0135049	4.690170e-01	0.2569273	8.561837e-01	Ppp2r2b	up
70	MSR1	MSR1	0.6293928	0.2584362	2.435390	0.0148758	0.0257520	0.0148758	0.0144026	1.876471e+00	1.1307343	3.114032e+00	Msr1	down
16	CCL27	CCL27	-10.1807420	4.9394362	-2.061114	0.0392921	0.0011244	0.0392921	0.0147958	3.790000e-05	0.0000000	6.067582e-01	Ccl27a	up
111	SLITRK5	SLITRK5	-0.4852339	0.1987193	-2.441806	0.0146140	0.0166802	0.0146140	0.0148097	6.155532e-01	0.4169802	9.086900e-01	Slitrk5	up
121	TFCP2L1	TFCP2L1	0.4640884	0.1932673	2.401277	0.0163379	0.0254705	0.0163379	0.0148488	1.590564e+00	1.0890344	2.323060e+00	Tfcp2l1	up
100	SCUBE3	SCUBE3	0.5114631	0.2125001	2.406884	0.0160893	0.0256815	0.0160893	0.0148709	1.667729e+00	1.0996264	2.529333e+00	Scube3	up
134	ZCCHC3	ZCCHC3	0.8449587	0.3501292	2.413277	0.0158098	0.0144719	0.0158098	0.0157013	2.327882e+00	1.1720075	4.623719e+00	Zcchc3	up
6	AHCYL2	AHCYL2	-0.4618186	0.1916865	-2.409239	0.0159858	0.0144949	0.0159858	0.0157534	6.301366e-01	0.4327837	9.174842e-01	Ahcyl2	up
84	PELI3	PELI3	-0.5361502	0.2219673	-2.415447	0.0157159	0.0125532	0.0157159	0.0158807	5.849960e-01	0.3786292	9.038405e-01	Peli3	up
117	SYT12	SYT12	-0.3974626	0.1658915	-2.395919	0.0165787	0.0103877	0.0165787	0.0161174	6.720231e-01	0.4854864	9.302320e-01	Syt12	up
61	LRRC6	LRRC6	-1.2100537	0.5083194	-2.380499	0.0172892	0.0148202	0.0172892	0.0162693	2.981813e-01	0.1101027	8.075373e-01	Lrrc6	up
77	OSR1	OSR1	0.2144682	0.0905432	2.368683	0.0178516	0.0251440	0.0178516	0.0166777	1.239203e+00	1.0377000	1.479834e+00	Osr1	up
90	PLK5	PLK5	-0.5414021	0.2291631	-2.362518	0.0181512	0.0166165	0.0181512	0.0175387	5.819318e-01	0.3713711	9.118766e-01	Plk5	up
59	LIX1	LIX1	-0.2840070	0.1205932	-2.355083	0.0185186	0.0237242	0.0185186	0.0177018	7.527614e-01	0.5943034	9.534687e-01	Lix1	up
45	GLRA3	GLRA3	-0.6180356	0.2634646	-2.345801	0.0189862	0.0133041	0.0189862	0.0185040	5.390022e-01	0.3216097	9.033416e-01	Glra3	up
71	NIPAL3	NIPAL3	0.3068599	0.1315510	2.332631	0.0196675	0.0202769	0.0196675	0.0189767	1.359150e+00	1.0502462	1.758911e+00	Nipal3	up
75	NSUN7	NSUN7	2.8988354	1.2476243	2.323484	0.0201532	0.0274793	0.0201532	0.0194083	1.815299e+01	1.5738687	2.093765e+02	Nsun7	up
3	ABLIM3	ABLIM3	-0.4204272	0.1804536	-2.329836	0.0198148	0.0196918	0.0198148	0.0196757	6.567662e-01	0.4611141	9.354340e-01	Ablim3	up
98	RNF32	RNF32	-0.7549155	0.3244026	-2.327095	0.0199602	0.0195812	0.0199602	0.0197767	4.700503e-01	0.2488928	8.877207e-01	Rnf32	up
30	CRYBB1	CRYBB1	-0.6109657	0.2598025	-2.351655	0.0186901	0.0162412	0.0186901	0.0199216	5.428264e-01	0.3262246	9.032443e-01	Crybb1	up
122	TNNI1	TNNI1	2.8923203	1.3335905	2.168822	0.0300962	0.0799377	0.0300962	0.0199732	1.803511e+01	1.3211876	2.461915e+02	Tnni1	up
91	POPDC3	POPDC3	0.3123546	0.1361879	2.293555	0.0218161	0.0284385	0.0218161	0.0201892	1.366639e+00	1.0464789	1.784749e+00	Popdc3	up
14	CAMSAP3	CAMSAP3	-0.2662145	0.1163447	-2.288152	0.0221286	0.0232764	0.0221286	0.0215514	7.662747e-01	0.6100307	9.625368e-01	Camsap3	up
42	FZD2	FZD2	0.3875964	0.1688566	2.295418	0.0217092	0.0214499	0.0217092	0.0216465	1.473435e+00	1.0582785	2.051455e+00	Fzd2	up
135	ZCCHC4	ZCCHC4	0.7571164	0.3109674	2.434713	0.0149036	0.0324878	0.0149036	0.0221649	2.132119e+00	1.1590857	3.921998e+00	Zcchc4	down
124	TPSB2	TPSB2	-0.4678065	0.2090684	-2.237576	0.0252487	0.0102559	0.0252487	0.0225107	6.263747e-01	0.4157908	9.436123e-01	Tpsb2	down
109	SLC4A4	SLC4A4	-0.4141597	0.1824616	-2.269846	0.0232169	0.0246088	0.0232169	0.0226269	6.608954e-01	0.4621906	9.450271e-01	Slc4a4	up
52	HTR2C	HTR2C	-3.1565775	1.3995778	-2.255378	0.0241096	0.0133067	0.0241096	0.0232918	4.257120e-02	0.0027403	6.613610e-01	Htr2c	up
108	SLC35F4	SLC35F4	6.9660928	3.4145385	2.040127	0.0413377	0.1207829	0.0413377	0.0234941	1.060073e+03	1.3148471	8.546653e+05	Slc35f4	up
39	FAM111A	FAM111A	0.4931808	0.2189509	2.252472	0.0242925	0.0261799	0.0242925	0.0238429	1.637517e+00	1.0661403	2.515110e+00	Fam111a	down
118	SYT17	SYT17	-0.6691720	0.2974328	-2.249826	0.0244600	0.0230309	0.0244600	0.0240354	5.121324e-01	0.2858953	9.173975e-01	Syt17	up
95	PROK2	PROK2	1.8148931	0.8212733	2.209853	0.0271154	0.0412250	0.0271154	0.0258169	6.140420e+00	1.2278037	3.070911e+01	Prok2	up
136	ZNF519	ZNF519	0.7099944	0.3196717	2.221011	0.0263502	0.0282681	0.0263502	0.0258965	2.033980e+00	1.0870303	3.805850e+00	Zfp941	up
92	PPIL6	PPIL6	-0.8190445	0.3663250	-2.235841	0.0253622	0.0228182	0.0253622	0.0262949	4.408527e-01	0.2150191	9.038782e-01	Ppil6	up
67	MEIG1	MEIG1	-1.4153405	0.6416480	-2.205790	0.0273987	0.0165410	0.0273987	0.0263250	2.428429e-01	0.0690484	8.540773e-01	Meig1	up
41	FRY	FRY	-0.6736747	0.3074954	-2.190845	0.0284630	0.0283663	0.0284630	0.0281425	5.098316e-01	0.2790527	9.314667e-01	Fry	up
24	CHST15	CHST15	-0.4167445	0.1902333	-2.190702	0.0284734	0.0278526	0.0284734	0.0281733	6.591893e-01	0.4540287	9.570553e-01	Chst15	up
19	CDH7	CDH7	-0.6616486	0.3054743	-2.165971	0.0303134	0.0216067	0.0303134	0.0286263	5.160000e-01	0.2835499	9.390093e-01	Cdh7	up
57	KNDC1	KNDC1	-0.2969632	0.1366881	-2.172560	0.0298134	0.0279141	0.0298134	0.0293196	7.430714e-01	0.5684358	9.713588e-01	Kndc1	up
125	TTC34	TTC34	-3.7733836	1.7457180	-2.161508	0.0306561	0.0235946	0.0306561	0.0297951	2.297420e-02	0.0007504	7.033933e-01	Ttc34	up
49	HHATL	HHATL	0.2470745	0.1144943	2.157963	0.0309307	0.0303280	0.0309307	0.0308650	1.280274e+00	1.0229287	1.602363e+00	Hhatl	up
53	KCNB1	KCNB1	-0.4829054	0.2251743	-2.144585	0.0319861	0.0281475	0.0319861	0.0316609	6.169882e-01	0.3968333	9.592804e-01	Kcnb1	up
51	HS6ST2	HS6ST2	0.8537621	0.4008883	2.129676	0.0331984	0.0357143	0.0331984	0.0317125	2.348466e+00	1.0704032	5.152535e+00	Hs6st2	up
126	TTLL11	TTLL11	1.3664702	0.6377193	2.142745	0.0321335	0.0412975	0.0321335	0.0321406	3.921484e+00	1.1236286	1.368605e+01	Ttll11	up
72	NLRP6	NLRP6	0.5442128	0.2548265	2.135621	0.0327103	0.0448962	0.0327103	0.0322133	1.723251e+00	1.0457789	2.839601e+00	Nlrp6	up
64	LUZP2	LUZP2	-0.3671389	0.1727341	-2.125457	0.0335485	0.0367364	0.0335485	0.0323780	6.927134e-01	0.4937670	9.718185e-01	Luzp2	up
10	BRINP1	BRINP1	-0.3392242	0.1600891	-2.118972	0.0340928	0.0305033	0.0340928	0.0324119	7.123227e-01	0.5204856	9.748658e-01	Brinp1	up
56	KLHDC9	KLHDC9	-0.2353128	0.1106619	-2.126413	0.0334689	0.0371299	0.0334689	0.0330566	7.903236e-01	0.6362230	9.817491e-01	Klhdc9	up
88	PLCB1	PLCB1	-0.6420079	0.3024846	-2.122448	0.0338001	0.0324093	0.0338001	0.0333069	5.262348e-01	0.2908735	9.520392e-01	Plcb1	up
105	SIDT1	SIDT1	-0.4174642	0.1983770	-2.104398	0.0353437	0.0278401	0.0353437	0.0339631	6.587150e-01	0.4465178	9.717541e-01	Sidt1	up
107	SLC1A2	SLC1A2	-0.2124443	0.1003561	-2.116904	0.0342680	0.0375824	0.0342680	0.0340428	8.086053e-01	0.6642221	9.843735e-01	Slc1a2	up
38	EMID1	EMID1	-0.4502308	0.2133506	-2.110287	0.0348337	0.0338802	0.0348337	0.0343860	6.374810e-01	0.4196265	9.684374e-01	Emid1	up
13	CACNA2D4	CACNA2D4	1.0245697	0.4891258	2.094696	0.0361980	0.0427101	0.0361980	0.0350024	2.785896e+00	1.0681207	7.266237e+00	Cacna2d4	up
76	NXPH3	NXPH3	-0.3774392	0.1806948	-2.088822	0.0367238	0.0409742	0.0367238	0.0363733	6.856149e-01	0.4811412	9.769850e-01	Nxph3	up
129	UNC13B	UNC13B	-0.7827685	0.3736143	-2.095125	0.0361599	0.0336327	0.0361599	0.0369294	4.571387e-01	0.2197996	9.507559e-01	Unc13b	up
132	WNT9A	WNT9A	0.6958626	0.3367280	2.066542	0.0387773	0.0463104	0.0387773	0.0378423	2.005438e+00	1.0365397	3.880008e+00	Wnt9a	up
112	SMIM1	SMIM1	0.5206950	0.2527491	2.060126	0.0393865	0.0428917	0.0393865	0.0385225	1.683197e+00	1.0256390	2.762329e+00	Smim1	up
9	BAIAP3	BAIAP3	-0.2794113	0.1351514	-2.067396	0.0386969	0.0418946	0.0386969	0.0390339	7.562288e-01	0.5802460	9.855853e-01	Baiap3	up
33	DMKN	DMKN	-0.3291229	0.1606125	-2.049173	0.0404452	0.0368210	0.0404452	0.0393216	7.195546e-01	0.5252307	9.857741e-01	Dmkn	up
115	SPRY3	SPRY3	0.4960903	0.2418322	2.051382	0.0402298	0.0386226	0.0402298	0.0404007	1.642288e+00	1.0223540	2.638136e+00	Spry3	up
2	ABHD3	ABHD3	0.5955091	0.2929307	2.032935	0.0420591	0.0407117	0.0420591	0.0409840	1.813954e+00	1.0216055	3.220842e+00	Abhd3	up
18	CD5L	CD5L	0.7754014	0.3848963	2.014572	0.0439495	0.1129359	0.0439495	0.0414056	2.171464e+00	1.0212410	4.617181e+00	Cd5l	down
58	LGI3	LGI3	0.1822722	0.0897599	2.030665	0.0422890	0.0443037	0.0422890	0.0414997	1.199941e+00	1.0063663	1.430749e+00	Lgi3	up
99	RSPO3	RSPO3	-0.6746499	0.3363098	-2.006037	0.0448523	0.0301619	0.0448523	0.0427121	5.093347e-01	0.2634728	9.846247e-01	Rspo3	up
32	DCHS2	DCHS2	-1.0486217	0.5210343	-2.012577	0.0441591	0.0349509	0.0441591	0.0427312	3.504204e-01	0.1262072	9.729591e-01	Dchs2	up
35	DNAH12	DNAH12	3.9025793	1.9420087	2.009558	0.0444780	0.0681526	0.0444780	0.0436603	4.953004e+01	1.1011029	2.227971e+03	Dnah12	up
31	CYB561	CYB561	-0.3508557	0.1754585	-1.999651	0.0455380	0.0350770	0.0455380	0.0445372	7.040854e-01	0.4992003	9.930608e-01	Cyb561	up
48	GPR176	GPR176	0.3455603	0.1729604	1.997916	0.0457257	0.0478815	0.0457257	0.0446132	1.412781e+00	1.0065858	1.982892e+00	Gpr176	up
34	DMRTC1	DMRTC1	98.5643120	49.8616264	1.976757	0.0480691	0.0630351	0.0480691	0.0448591	6.396418e+42	2.3101676	1.771047e+85	Dmrtc1a	up
116	SPTBN5	SPTBN5	0.6025659	0.3021065	1.994548	0.0460922	0.0585582	0.0460922	0.0449381	1.826800e+00	1.0105029	3.302513e+00	Sptbn5	up
8	ARPP21	ARPP21	-0.3743726	0.1867061	-2.005144	0.0449477	0.0462126	0.0449477	0.0451881	6.877206e-01	0.4769661	9.916001e-01	Arpp21	up
7	ALDOC	ALDOC	-0.2765491	0.1381129	-2.002341	0.0452480	0.0542366	0.0452480	0.0455496	7.583964e-01	0.5785413	9.941643e-01	Aldoc	up
23	CHST1	CHST1	-0.2144981	0.1081277	-1.983748	0.0472839	0.0521806	0.0472839	0.0467366	8.069463e-01	0.6528391	9.974316e-01	Chst1	up
131	WNT4	WNT4	-0.7042827	0.3598625	-1.957089	0.0503371	0.0247391	0.0503371	0.0469690	4.944631e-01	0.2442409	1.001035e+00	Wnt4	up
20	CDK6	CDK6	0.3824756	0.1938366	1.973185	0.0484744	0.0528413	0.0484744	0.0485995	1.465909e+00	1.0025661	2.143389e+00	Cdk6	down
97	RASGRF1	RASGRF1	-0.2693178	0.1370775	-1.964712	0.0494476	0.0439386	0.0494476	0.0487218	7.639004e-01	0.5839238	9.993493e-01	Rasgrf1	up
4	ADAMTS3	ADAMTS3	1.9769091	0.9586936	2.062086	0.0391995	0.0865033	0.0391995	0.0488657	7.220391e+00	1.1028571	4.727180e+01	Adamts3	up
119	SYT3	SYT3	-0.3410561	0.1739619	-1.960522	0.0499348	0.0391895	0.0499348	0.0489593	7.110190e-01	0.5055971	9.999029e-01	Syt3	up
81	PCDHGA4	PCDHGA4	1.0331251	0.5206786	1.984190	0.0472347	0.0638059	0.0472347	0.0497464	2.809833e+00	1.0126938	7.796199e+00	Pcdhga4	up
63	LSAMP	LSAMP	-0.6089189	0.3110885	-1.957382	0.0503026	0.0520013	0.0503026	0.0499826	5.439386e-01	0.2956316	1.000804e+00	Lsamp	up

GBM_LGG

Gene-sets considered

UP and DOWN

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Table genes

	Variable	Term	Beta	StandardError	Z	P	LRT	Wald	LogRank	HR	HRlower	HRupper	mm	status
47	GPR139	GPR139	2.9954716	0.5459944	5.486268	0.0000000	0.0000008	0.0000000	0.0000000	1.999479e+01	6.8574946	5.829993e+01	Gpr139	up
11	BVES	BVES	0.7842063	0.1424517	5.505070	0.0000000	0.0000025	0.0000000	0.0000001	2.190667e+00	1.6569958	2.896220e+00	Bves	up
22	CHIC2	CHIC2	1.1744777	0.2267115	5.180495	0.0000002	0.0000079	0.0000002	0.0000002	3.236452e+00	2.0753531	5.047152e+00	Chic2	down
62	LRRK2	LRRK2	0.6724442	0.1341983	5.010825	0.0000005	0.0000059	0.0000005	0.0000002	1.959020e+00	1.5059447	2.548406e+00	Lrrk2	up
21	CEP135	CEP135	1.1901584	0.2479228	4.800520	0.0000016	0.0000491	0.0000016	0.0000014	3.287602e+00	2.0223064	5.344554e+00	Cep135	down
133	ZBTB8B	ZBTB8B	1.1045218	0.2349319	4.701455	0.0000026	0.0000192	0.0000026	0.0000022	3.017781e+00	1.9042034	4.782579e+00	Zbtb8b	up
86	PI4K2B	PI4K2B	1.0371524	0.2498474	4.151143	0.0000331	0.0015532	0.0000331	0.0000217	2.821172e+00	1.7288568	4.603626e+00	Pi4k2b	down
102	SERINC2	SERINC2	0.6263722	0.1610620	3.889012	0.0001007	0.0002453	0.0001007	0.0000827	1.870811e+00	1.3643749	2.565230e+00	Serinc2	up
104	SH3GL2	SH3GL2	-0.7907620	0.2005988	-3.942008	0.0000808	0.0000695	0.0000808	0.0001115	4.534991e-01	0.3060740	6.719337e-01	Sh3gl2	up
15	CCDC87	CCDC87	-0.7788043	0.2036870	-3.823535	0.0001316	0.0001516	0.0001316	0.0001223	4.589545e-01	0.3078867	6.841452e-01	Ccdc87	up
80	PCDHGA3	PCDHGA3	0.6336887	0.1854916	3.416266	0.0006349	0.0047731	0.0006349	0.0001990	1.884549e+00	1.3101371	2.710805e+00	Pcdhga3	up
101	SEPSECS	SEPSECS	1.0745060	0.2684215	4.003055	0.0000625	0.0004790	0.0000625	0.0002610	2.928546e+00	1.7304985	4.956017e+00	Sepsecs	down
78	PAX5	PAX5	4.3732708	1.3013911	3.360458	0.0007781	0.0111408	0.0007781	0.0002911	7.930259e+01	6.1878707	1.016327e+03	Pax5	down
54	KCNG1	KCNG1	-0.5347163	0.1540201	-3.471731	0.0005171	0.0001938	0.0005171	0.0004520	5.858355e-01	0.4331851	7.922784e-01	Kcng1	up
85	PHKG1	PHKG1	-0.3998301	0.1165522	-3.430480	0.0006025	0.0009269	0.0006025	0.0004617	6.704339e-01	0.5335149	8.424913e-01	Phkg1	up
50	HHIP	HHIP	0.5367070	0.1575686	3.406179	0.0006588	0.0014311	0.0006588	0.0005304	1.710365e+00	1.2559323	2.329225e+00	Hhip	up
36	EFCAB6	EFCAB6	-7.0065194	2.0604116	-3.400543	0.0006725	0.0002490	0.0006725	0.0005886	9.060000e-04	0.0000160	5.139640e-02	Efcab6	up
68	METTL11B	METTL11B	2.6216611	0.8373169	3.131026	0.0017420	0.0097680	0.0017420	0.0007621	1.375856e+01	2.6659224	7.100655e+01	Mettl11b	up
89	PLCXD1	PLCXD1	0.6979770	0.2051305	3.402601	0.0006675	0.0009493	0.0006675	0.0007977	2.009683e+00	1.3443743	3.004242e+00	Plcxd1	up
25	CLEC18A	CLEC18A	2.0090652	0.6175386	3.253344	0.0011406	0.0037224	0.0011406	0.0009366	7.456344e+00	2.2226761	2.501357e+01	Clec18a	up
82	PCDHGA8	PCDHGA8	4.5064285	1.4663795	3.073167	0.0021180	0.0114419	0.0021180	0.0016940	9.059767e+01	5.1160230	1.604359e+03	Pcdhga8	up
79	PCDH7	PCDH7	-0.7147787	0.2368258	-3.018163	0.0025431	0.0019136	0.0025431	0.0024481	4.893004e-01	0.3076020	7.783268e-01	Pcdh7	up
17	CCNB2	CCNB2	0.3221457	0.1089420	2.957039	0.0031061	0.0046368	0.0031061	0.0027830	1.380086e+00	1.1147424	1.708589e+00	Ccnb2	down
1	ABCA8	ABCA8	0.4256288	0.1413422	3.011336	0.0026010	0.0059862	0.0026010	0.0030725	1.530552e+00	1.1602125	2.019105e+00	Abca8b	up
43	GDF10	GDF10	-0.3061819	0.1055962	-2.899555	0.0037369	0.0022250	0.0037369	0.0032660	7.362527e-01	0.5986090	9.055460e-01	Gdf10	up
44	GJA1	GJA1	-0.4050831	0.1380017	-2.935349	0.0033317	0.0035724	0.0033317	0.0034714	6.669214e-01	0.5088706	8.740613e-01	Gja1	up
29	CRTAC1	CRTAC1	-0.5539521	0.1912721	-2.896147	0.0037778	0.0040257	0.0037778	0.0037843	5.746742e-01	0.3950123	8.360510e-01	Crtac1	up
74	NRG3	NRG3	-2.4032161	0.8375289	-2.869413	0.0041123	0.0031459	0.0041123	0.0039243	9.042670e-02	0.0175142	4.668770e-01	Nrg3	up
123	TPSAB1	TPSAB1	-0.7426437	0.2748043	-2.702446	0.0068831	0.0004653	0.0068831	0.0039419	4.758542e-01	0.2776899	8.154320e-01	Tpsb2	down
128	TUB	TUB	-0.5196510	0.1808249	-2.873780	0.0040559	0.0047320	0.0040559	0.0041056	5.947281e-01	0.4172535	8.476897e-01	Tub	up
103	SFTPC	SFTPC	0.4223342	0.1487355	2.839498	0.0045185	0.0058762	0.0045185	0.0041667	1.525518e+00	1.1397603	2.041838e+00	Sftpc	up
120	TCHH	TCHH	-0.5988549	0.2142769	-2.794771	0.0051936	0.0025865	0.0051936	0.0050215	5.494404e-01	0.3610171	8.362064e-01	Tchh	up
130	VWC2	VWC2	-0.8118496	0.2985573	-2.719242	0.0065432	0.0042834	0.0065432	0.0057806	4.440360e-01	0.2473351	7.971695e-01	Vwc2	up
27	CNGA4	CNGA4	-1.0359853	0.3821171	-2.711172	0.0067046	0.0040296	0.0067046	0.0063590	3.548765e-01	0.1678103	7.504746e-01	Cnga4	up
114	SPHKAP	SPHKAP	-0.4625777	0.1721975	-2.686321	0.0072244	0.0065275	0.0072244	0.0068047	6.296585e-01	0.4492936	8.824291e-01	Sphkap	up
46	GLT8D2	GLT8D2	-1.6440659	0.6170412	-2.664435	0.0077118	0.0045787	0.0077118	0.0071151	1.931929e-01	0.0576454	6.474670e-01	Glt8d2	up
40	FAM186B	FAM186B	2.7648858	1.0270985	2.691938	0.0071038	0.0102688	0.0071038	0.0071928	1.587723e+01	2.1208349	1.188618e+02	Fam186b	up
5	ADCY2	ADCY2	-0.5091532	0.1915128	-2.658586	0.0078469	0.0086014	0.0078469	0.0075234	6.010043e-01	0.4129159	8.747693e-01	Adcy2	up
87	PLA2G4E	PLA2G4E	19.0823473	7.2463960	2.633357	0.0084545	0.0379296	0.0084545	0.0081310	1.938019e+08	131.5875091	2.854313e+14	Pla2g4e	up
96	RAB42	RAB42	0.5038644	0.1915025	2.631111	0.0085106	0.0086515	0.0085106	0.0084776	1.655105e+00	1.1371513	2.408978e+00	Rab42	up
73	NR3C2	NR3C2	-1.1889369	0.4523989	-2.628072	0.0085870	0.0066070	0.0085870	0.0085969	3.045449e-01	0.1254783	7.391523e-01	Nr3c2	up
60	LRRC18	LRRC18	0.8248612	0.3172093	2.600369	0.0093124	0.0202333	0.0093124	0.0094480	2.281564e+00	1.2252469	4.248560e+00	Lrrc18	up
66	MAP6D1	MAP6D1	0.3520670	0.1365555	2.578198	0.0099317	0.0104100	0.0099317	0.0094586	1.422004e+00	1.0880893	1.858390e+00	Map6d1	up
69	MGAT4C	MGAT4C	-1.3821722	0.5241332	-2.637063	0.0083627	0.0040005	0.0083627	0.0095399	2.510327e-01	0.0898643	7.012506e-01	Mgat4c	up
106	SLAIN2	SLAIN2	0.8455718	0.3292619	2.568083	0.0102263	0.0111327	0.0102263	0.0096223	2.329309e+00	1.2216841	4.441149e+00	Slain2	down
113	SPAG17	SPAG17	10.0872014	4.2371258	2.380671	0.0172812	0.0574988	0.0172812	0.0110288	2.403344e+04	5.9452191	9.715474e+07	Spag17	up
37	EFEMP1	EFEMP1	-0.2914440	0.1149583	-2.535214	0.0112379	0.0122232	0.0112379	0.0111204	7.471839e-01	0.5964510	9.360093e-01	Efemp1	up
12	CACNA2D2	CACNA2D2	-0.8043295	0.3205444	-2.509261	0.0120984	0.0098839	0.0120984	0.0118147	4.473878e-01	0.2386911	8.385559e-01	Cacna2d2	up
55	KLF14	KLF14	1.6071670	0.6370812	2.522703	0.0116457	0.0346226	0.0116457	0.0119965	4.988658e+00	1.4311964	1.738875e+01	Klf14	up
127	TTLL7	TTLL7	0.4510948	0.1808449	2.494374	0.0126179	0.0140847	0.0126179	0.0121624	1.570030e+00	1.1014697	2.237914e+00	Ttll7	up
28	CPA3	CPA3	-2.6676371	1.2839007	-2.077760	0.0377315	0.0010779	0.0377315	0.0122039	6.941610e-02	0.0056053	8.596431e-01	Cpa3	down
94	PRIMA1	PRIMA1	0.6222890	0.2488279	2.500881	0.0123885	0.0134312	0.0123885	0.0122378	1.863188e+00	1.1440737	3.034306e+00	Prima1	up
110	SLC7A11	SLC7A11	-0.5173928	0.2068672	-2.501087	0.0123813	0.0111473	0.0123813	0.0128561	5.960726e-01	0.3973869	8.940974e-01	Slc7a11	up
83	PDGFRA	PDGFRA	0.3197732	0.1282574	2.493214	0.0126593	0.0114151	0.0126593	0.0129613	1.376815e+00	1.0707863	1.770307e+00	Pdgfra	down
65	MAGEE2	MAGEE2	0.2072085	0.0847911	2.443752	0.0145354	0.0121291	0.0145354	0.0129998	1.230239e+00	1.0418739	1.452659e+00	Magee2	up
26	CLMN	CLMN	0.5914685	0.2374123	2.491314	0.0127272	0.0186262	0.0127272	0.0131366	1.806639e+00	1.1344511	2.877115e+00	Clmn	up
93	PPP2R2B	PPP2R2B	-0.7571162	0.3070699	-2.465615	0.0136778	0.0122080	0.0136778	0.0135049	4.690170e-01	0.2569273	8.561837e-01	Ppp2r2b	up
70	MSR1	MSR1	0.6293928	0.2584362	2.435390	0.0148758	0.0257520	0.0148758	0.0144026	1.876471e+00	1.1307343	3.114032e+00	Msr1	down
16	CCL27	CCL27	-10.1807420	4.9394362	-2.061114	0.0392921	0.0011244	0.0392921	0.0147958	3.790000e-05	0.0000000	6.067582e-01	Ccl27a	up
111	SLITRK5	SLITRK5	-0.4852339	0.1987193	-2.441806	0.0146140	0.0166802	0.0146140	0.0148097	6.155532e-01	0.4169802	9.086900e-01	Slitrk5	up
121	TFCP2L1	TFCP2L1	0.4640884	0.1932673	2.401277	0.0163379	0.0254705	0.0163379	0.0148488	1.590564e+00	1.0890344	2.323060e+00	Tfcp2l1	up
100	SCUBE3	SCUBE3	0.5114631	0.2125001	2.406884	0.0160893	0.0256815	0.0160893	0.0148709	1.667729e+00	1.0996264	2.529333e+00	Scube3	up
134	ZCCHC3	ZCCHC3	0.8449587	0.3501292	2.413277	0.0158098	0.0144719	0.0158098	0.0157013	2.327882e+00	1.1720075	4.623719e+00	Zcchc3	up
6	AHCYL2	AHCYL2	-0.4618186	0.1916865	-2.409239	0.0159858	0.0144949	0.0159858	0.0157534	6.301366e-01	0.4327837	9.174842e-01	Ahcyl2	up
84	PELI3	PELI3	-0.5361502	0.2219673	-2.415447	0.0157159	0.0125532	0.0157159	0.0158807	5.849960e-01	0.3786292	9.038405e-01	Peli3	up
117	SYT12	SYT12	-0.3974626	0.1658915	-2.395919	0.0165787	0.0103877	0.0165787	0.0161174	6.720231e-01	0.4854864	9.302320e-01	Syt12	up
61	LRRC6	LRRC6	-1.2100537	0.5083194	-2.380499	0.0172892	0.0148202	0.0172892	0.0162693	2.981813e-01	0.1101027	8.075373e-01	Lrrc6	up
77	OSR1	OSR1	0.2144682	0.0905432	2.368683	0.0178516	0.0251440	0.0178516	0.0166777	1.239203e+00	1.0377000	1.479834e+00	Osr1	up
90	PLK5	PLK5	-0.5414021	0.2291631	-2.362518	0.0181512	0.0166165	0.0181512	0.0175387	5.819318e-01	0.3713711	9.118766e-01	Plk5	up
59	LIX1	LIX1	-0.2840070	0.1205932	-2.355083	0.0185186	0.0237242	0.0185186	0.0177018	7.527614e-01	0.5943034	9.534687e-01	Lix1	up
45	GLRA3	GLRA3	-0.6180356	0.2634646	-2.345801	0.0189862	0.0133041	0.0189862	0.0185040	5.390022e-01	0.3216097	9.033416e-01	Glra3	up
71	NIPAL3	NIPAL3	0.3068599	0.1315510	2.332631	0.0196675	0.0202769	0.0196675	0.0189767	1.359150e+00	1.0502462	1.758911e+00	Nipal3	up
75	NSUN7	NSUN7	2.8988354	1.2476243	2.323484	0.0201532	0.0274793	0.0201532	0.0194083	1.815299e+01	1.5738687	2.093765e+02	Nsun7	up
3	ABLIM3	ABLIM3	-0.4204272	0.1804536	-2.329836	0.0198148	0.0196918	0.0198148	0.0196757	6.567662e-01	0.4611141	9.354340e-01	Ablim3	up
98	RNF32	RNF32	-0.7549155	0.3244026	-2.327095	0.0199602	0.0195812	0.0199602	0.0197767	4.700503e-01	0.2488928	8.877207e-01	Rnf32	up
30	CRYBB1	CRYBB1	-0.6109657	0.2598025	-2.351655	0.0186901	0.0162412	0.0186901	0.0199216	5.428264e-01	0.3262246	9.032443e-01	Crybb1	up
122	TNNI1	TNNI1	2.8923203	1.3335905	2.168822	0.0300962	0.0799377	0.0300962	0.0199732	1.803511e+01	1.3211876	2.461915e+02	Tnni1	up
91	POPDC3	POPDC3	0.3123546	0.1361879	2.293555	0.0218161	0.0284385	0.0218161	0.0201892	1.366639e+00	1.0464789	1.784749e+00	Popdc3	up
14	CAMSAP3	CAMSAP3	-0.2662145	0.1163447	-2.288152	0.0221286	0.0232764	0.0221286	0.0215514	7.662747e-01	0.6100307	9.625368e-01	Camsap3	up
42	FZD2	FZD2	0.3875964	0.1688566	2.295418	0.0217092	0.0214499	0.0217092	0.0216465	1.473435e+00	1.0582785	2.051455e+00	Fzd2	up
135	ZCCHC4	ZCCHC4	0.7571164	0.3109674	2.434713	0.0149036	0.0324878	0.0149036	0.0221649	2.132119e+00	1.1590857	3.921998e+00	Zcchc4	down
124	TPSB2	TPSB2	-0.4678065	0.2090684	-2.237576	0.0252487	0.0102559	0.0252487	0.0225107	6.263747e-01	0.4157908	9.436123e-01	Tpsb2	down
109	SLC4A4	SLC4A4	-0.4141597	0.1824616	-2.269846	0.0232169	0.0246088	0.0232169	0.0226269	6.608954e-01	0.4621906	9.450271e-01	Slc4a4	up
52	HTR2C	HTR2C	-3.1565775	1.3995778	-2.255378	0.0241096	0.0133067	0.0241096	0.0232918	4.257120e-02	0.0027403	6.613610e-01	Htr2c	up
108	SLC35F4	SLC35F4	6.9660928	3.4145385	2.040127	0.0413377	0.1207829	0.0413377	0.0234941	1.060073e+03	1.3148471	8.546653e+05	Slc35f4	up
39	FAM111A	FAM111A	0.4931808	0.2189509	2.252472	0.0242925	0.0261799	0.0242925	0.0238429	1.637517e+00	1.0661403	2.515110e+00	Fam111a	down
118	SYT17	SYT17	-0.6691720	0.2974328	-2.249826	0.0244600	0.0230309	0.0244600	0.0240354	5.121324e-01	0.2858953	9.173975e-01	Syt17	up
95	PROK2	PROK2	1.8148931	0.8212733	2.209853	0.0271154	0.0412250	0.0271154	0.0258169	6.140420e+00	1.2278037	3.070911e+01	Prok2	up
136	ZNF519	ZNF519	0.7099944	0.3196717	2.221011	0.0263502	0.0282681	0.0263502	0.0258965	2.033980e+00	1.0870303	3.805850e+00	Zfp941	up
92	PPIL6	PPIL6	-0.8190445	0.3663250	-2.235841	0.0253622	0.0228182	0.0253622	0.0262949	4.408527e-01	0.2150191	9.038782e-01	Ppil6	up
67	MEIG1	MEIG1	-1.4153405	0.6416480	-2.205790	0.0273987	0.0165410	0.0273987	0.0263250	2.428429e-01	0.0690484	8.540773e-01	Meig1	up
41	FRY	FRY	-0.6736747	0.3074954	-2.190845	0.0284630	0.0283663	0.0284630	0.0281425	5.098316e-01	0.2790527	9.314667e-01	Fry	up
24	CHST15	CHST15	-0.4167445	0.1902333	-2.190702	0.0284734	0.0278526	0.0284734	0.0281733	6.591893e-01	0.4540287	9.570553e-01	Chst15	up
19	CDH7	CDH7	-0.6616486	0.3054743	-2.165971	0.0303134	0.0216067	0.0303134	0.0286263	5.160000e-01	0.2835499	9.390093e-01	Cdh7	up
57	KNDC1	KNDC1	-0.2969632	0.1366881	-2.172560	0.0298134	0.0279141	0.0298134	0.0293196	7.430714e-01	0.5684358	9.713588e-01	Kndc1	up
125	TTC34	TTC34	-3.7733836	1.7457180	-2.161508	0.0306561	0.0235946	0.0306561	0.0297951	2.297420e-02	0.0007504	7.033933e-01	Ttc34	up
49	HHATL	HHATL	0.2470745	0.1144943	2.157963	0.0309307	0.0303280	0.0309307	0.0308650	1.280274e+00	1.0229287	1.602363e+00	Hhatl	up
53	KCNB1	KCNB1	-0.4829054	0.2251743	-2.144585	0.0319861	0.0281475	0.0319861	0.0316609	6.169882e-01	0.3968333	9.592804e-01	Kcnb1	up
51	HS6ST2	HS6ST2	0.8537621	0.4008883	2.129676	0.0331984	0.0357143	0.0331984	0.0317125	2.348466e+00	1.0704032	5.152535e+00	Hs6st2	up
126	TTLL11	TTLL11	1.3664702	0.6377193	2.142745	0.0321335	0.0412975	0.0321335	0.0321406	3.921484e+00	1.1236286	1.368605e+01	Ttll11	up
72	NLRP6	NLRP6	0.5442128	0.2548265	2.135621	0.0327103	0.0448962	0.0327103	0.0322133	1.723251e+00	1.0457789	2.839601e+00	Nlrp6	up
64	LUZP2	LUZP2	-0.3671389	0.1727341	-2.125457	0.0335485	0.0367364	0.0335485	0.0323780	6.927134e-01	0.4937670	9.718185e-01	Luzp2	up
10	BRINP1	BRINP1	-0.3392242	0.1600891	-2.118972	0.0340928	0.0305033	0.0340928	0.0324119	7.123227e-01	0.5204856	9.748658e-01	Brinp1	up
56	KLHDC9	KLHDC9	-0.2353128	0.1106619	-2.126413	0.0334689	0.0371299	0.0334689	0.0330566	7.903236e-01	0.6362230	9.817491e-01	Klhdc9	up
88	PLCB1	PLCB1	-0.6420079	0.3024846	-2.122448	0.0338001	0.0324093	0.0338001	0.0333069	5.262348e-01	0.2908735	9.520392e-01	Plcb1	up
105	SIDT1	SIDT1	-0.4174642	0.1983770	-2.104398	0.0353437	0.0278401	0.0353437	0.0339631	6.587150e-01	0.4465178	9.717541e-01	Sidt1	up
107	SLC1A2	SLC1A2	-0.2124443	0.1003561	-2.116904	0.0342680	0.0375824	0.0342680	0.0340428	8.086053e-01	0.6642221	9.843735e-01	Slc1a2	up
38	EMID1	EMID1	-0.4502308	0.2133506	-2.110287	0.0348337	0.0338802	0.0348337	0.0343860	6.374810e-01	0.4196265	9.684374e-01	Emid1	up
13	CACNA2D4	CACNA2D4	1.0245697	0.4891258	2.094696	0.0361980	0.0427101	0.0361980	0.0350024	2.785896e+00	1.0681207	7.266237e+00	Cacna2d4	up
76	NXPH3	NXPH3	-0.3774392	0.1806948	-2.088822	0.0367238	0.0409742	0.0367238	0.0363733	6.856149e-01	0.4811412	9.769850e-01	Nxph3	up
129	UNC13B	UNC13B	-0.7827685	0.3736143	-2.095125	0.0361599	0.0336327	0.0361599	0.0369294	4.571387e-01	0.2197996	9.507559e-01	Unc13b	up
132	WNT9A	WNT9A	0.6958626	0.3367280	2.066542	0.0387773	0.0463104	0.0387773	0.0378423	2.005438e+00	1.0365397	3.880008e+00	Wnt9a	up
112	SMIM1	SMIM1	0.5206950	0.2527491	2.060126	0.0393865	0.0428917	0.0393865	0.0385225	1.683197e+00	1.0256390	2.762329e+00	Smim1	up
9	BAIAP3	BAIAP3	-0.2794113	0.1351514	-2.067396	0.0386969	0.0418946	0.0386969	0.0390339	7.562288e-01	0.5802460	9.855853e-01	Baiap3	up
33	DMKN	DMKN	-0.3291229	0.1606125	-2.049173	0.0404452	0.0368210	0.0404452	0.0393216	7.195546e-01	0.5252307	9.857741e-01	Dmkn	up
115	SPRY3	SPRY3	0.4960903	0.2418322	2.051382	0.0402298	0.0386226	0.0402298	0.0404007	1.642288e+00	1.0223540	2.638136e+00	Spry3	up
2	ABHD3	ABHD3	0.5955091	0.2929307	2.032935	0.0420591	0.0407117	0.0420591	0.0409840	1.813954e+00	1.0216055	3.220842e+00	Abhd3	up
18	CD5L	CD5L	0.7754014	0.3848963	2.014572	0.0439495	0.1129359	0.0439495	0.0414056	2.171464e+00	1.0212410	4.617181e+00	Cd5l	down
58	LGI3	LGI3	0.1822722	0.0897599	2.030665	0.0422890	0.0443037	0.0422890	0.0414997	1.199941e+00	1.0063663	1.430749e+00	Lgi3	up
99	RSPO3	RSPO3	-0.6746499	0.3363098	-2.006037	0.0448523	0.0301619	0.0448523	0.0427121	5.093347e-01	0.2634728	9.846247e-01	Rspo3	up
32	DCHS2	DCHS2	-1.0486217	0.5210343	-2.012577	0.0441591	0.0349509	0.0441591	0.0427312	3.504204e-01	0.1262072	9.729591e-01	Dchs2	up
35	DNAH12	DNAH12	3.9025793	1.9420087	2.009558	0.0444780	0.0681526	0.0444780	0.0436603	4.953004e+01	1.1011029	2.227971e+03	Dnah12	up
31	CYB561	CYB561	-0.3508557	0.1754585	-1.999651	0.0455380	0.0350770	0.0455380	0.0445372	7.040854e-01	0.4992003	9.930608e-01	Cyb561	up
48	GPR176	GPR176	0.3455603	0.1729604	1.997916	0.0457257	0.0478815	0.0457257	0.0446132	1.412781e+00	1.0065858	1.982892e+00	Gpr176	up
34	DMRTC1	DMRTC1	98.5643120	49.8616264	1.976757	0.0480691	0.0630351	0.0480691	0.0448591	6.396418e+42	2.3101676	1.771047e+85	Dmrtc1a	up
116	SPTBN5	SPTBN5	0.6025659	0.3021065	1.994548	0.0460922	0.0585582	0.0460922	0.0449381	1.826800e+00	1.0105029	3.302513e+00	Sptbn5	up
8	ARPP21	ARPP21	-0.3743726	0.1867061	-2.005144	0.0449477	0.0462126	0.0449477	0.0451881	6.877206e-01	0.4769661	9.916001e-01	Arpp21	up
7	ALDOC	ALDOC	-0.2765491	0.1381129	-2.002341	0.0452480	0.0542366	0.0452480	0.0455496	7.583964e-01	0.5785413	9.941643e-01	Aldoc	up
23	CHST1	CHST1	-0.2144981	0.1081277	-1.983748	0.0472839	0.0521806	0.0472839	0.0467366	8.069463e-01	0.6528391	9.974316e-01	Chst1	up
131	WNT4	WNT4	-0.7042827	0.3598625	-1.957089	0.0503371	0.0247391	0.0503371	0.0469690	4.944631e-01	0.2442409	1.001035e+00	Wnt4	up
20	CDK6	CDK6	0.3824756	0.1938366	1.973185	0.0484744	0.0528413	0.0484744	0.0485995	1.465909e+00	1.0025661	2.143389e+00	Cdk6	down
97	RASGRF1	RASGRF1	-0.2693178	0.1370775	-1.964712	0.0494476	0.0439386	0.0494476	0.0487218	7.639004e-01	0.5839238	9.993493e-01	Rasgrf1	up
4	ADAMTS3	ADAMTS3	1.9769091	0.9586936	2.062086	0.0391995	0.0865033	0.0391995	0.0488657	7.220391e+00	1.1028571	4.727180e+01	Adamts3	up
119	SYT3	SYT3	-0.3410561	0.1739619	-1.960522	0.0499348	0.0391895	0.0499348	0.0489593	7.110190e-01	0.5055971	9.999029e-01	Syt3	up
81	PCDHGA4	PCDHGA4	1.0331251	0.5206786	1.984190	0.0472347	0.0638059	0.0472347	0.0497464	2.809833e+00	1.0126938	7.796199e+00	Pcdhga4	up
63	LSAMP	LSAMP	-0.6089189	0.3110885	-1.957382	0.0503026	0.0520013	0.0503026	0.0499826	5.439386e-01	0.2956316	1.000804e+00	Lsamp	up

only GBM

Gene-sets considered

UP and DOWN

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Table genes

	Variable	Term	Beta	StandardError	Z	P	LRT	Wald	LogRank	HR	HRlower	HRupper	mm	status
47	GPR139	GPR139	2.9954716	0.5459944	5.486268	0.0000000	0.0000008	0.0000000	0.0000000	1.999479e+01	6.8574946	5.829993e+01	Gpr139	up
11	BVES	BVES	0.7842063	0.1424517	5.505070	0.0000000	0.0000025	0.0000000	0.0000001	2.190667e+00	1.6569958	2.896220e+00	Bves	up
22	CHIC2	CHIC2	1.1744777	0.2267115	5.180495	0.0000002	0.0000079	0.0000002	0.0000002	3.236452e+00	2.0753531	5.047152e+00	Chic2	down
62	LRRK2	LRRK2	0.6724442	0.1341983	5.010825	0.0000005	0.0000059	0.0000005	0.0000002	1.959020e+00	1.5059447	2.548406e+00	Lrrk2	up
21	CEP135	CEP135	1.1901584	0.2479228	4.800520	0.0000016	0.0000491	0.0000016	0.0000014	3.287602e+00	2.0223064	5.344554e+00	Cep135	down
133	ZBTB8B	ZBTB8B	1.1045218	0.2349319	4.701455	0.0000026	0.0000192	0.0000026	0.0000022	3.017781e+00	1.9042034	4.782579e+00	Zbtb8b	up
86	PI4K2B	PI4K2B	1.0371524	0.2498474	4.151143	0.0000331	0.0015532	0.0000331	0.0000217	2.821172e+00	1.7288568	4.603626e+00	Pi4k2b	down
102	SERINC2	SERINC2	0.6263722	0.1610620	3.889012	0.0001007	0.0002453	0.0001007	0.0000827	1.870811e+00	1.3643749	2.565230e+00	Serinc2	up
104	SH3GL2	SH3GL2	-0.7907620	0.2005988	-3.942008	0.0000808	0.0000695	0.0000808	0.0001115	4.534991e-01	0.3060740	6.719337e-01	Sh3gl2	up
15	CCDC87	CCDC87	-0.7788043	0.2036870	-3.823535	0.0001316	0.0001516	0.0001316	0.0001223	4.589545e-01	0.3078867	6.841452e-01	Ccdc87	up
80	PCDHGA3	PCDHGA3	0.6336887	0.1854916	3.416266	0.0006349	0.0047731	0.0006349	0.0001990	1.884549e+00	1.3101371	2.710805e+00	Pcdhga3	up
101	SEPSECS	SEPSECS	1.0745060	0.2684215	4.003055	0.0000625	0.0004790	0.0000625	0.0002610	2.928546e+00	1.7304985	4.956017e+00	Sepsecs	down
78	PAX5	PAX5	4.3732708	1.3013911	3.360458	0.0007781	0.0111408	0.0007781	0.0002911	7.930259e+01	6.1878707	1.016327e+03	Pax5	down
54	KCNG1	KCNG1	-0.5347163	0.1540201	-3.471731	0.0005171	0.0001938	0.0005171	0.0004520	5.858355e-01	0.4331851	7.922784e-01	Kcng1	up
85	PHKG1	PHKG1	-0.3998301	0.1165522	-3.430480	0.0006025	0.0009269	0.0006025	0.0004617	6.704339e-01	0.5335149	8.424913e-01	Phkg1	up
50	HHIP	HHIP	0.5367070	0.1575686	3.406179	0.0006588	0.0014311	0.0006588	0.0005304	1.710365e+00	1.2559323	2.329225e+00	Hhip	up
36	EFCAB6	EFCAB6	-7.0065194	2.0604116	-3.400543	0.0006725	0.0002490	0.0006725	0.0005886	9.060000e-04	0.0000160	5.139640e-02	Efcab6	up
68	METTL11B	METTL11B	2.6216611	0.8373169	3.131026	0.0017420	0.0097680	0.0017420	0.0007621	1.375856e+01	2.6659224	7.100655e+01	Mettl11b	up
89	PLCXD1	PLCXD1	0.6979770	0.2051305	3.402601	0.0006675	0.0009493	0.0006675	0.0007977	2.009683e+00	1.3443743	3.004242e+00	Plcxd1	up
25	CLEC18A	CLEC18A	2.0090652	0.6175386	3.253344	0.0011406	0.0037224	0.0011406	0.0009366	7.456344e+00	2.2226761	2.501357e+01	Clec18a	up
82	PCDHGA8	PCDHGA8	4.5064285	1.4663795	3.073167	0.0021180	0.0114419	0.0021180	0.0016940	9.059767e+01	5.1160230	1.604359e+03	Pcdhga8	up
79	PCDH7	PCDH7	-0.7147787	0.2368258	-3.018163	0.0025431	0.0019136	0.0025431	0.0024481	4.893004e-01	0.3076020	7.783268e-01	Pcdh7	up
17	CCNB2	CCNB2	0.3221457	0.1089420	2.957039	0.0031061	0.0046368	0.0031061	0.0027830	1.380086e+00	1.1147424	1.708589e+00	Ccnb2	down
1	ABCA8	ABCA8	0.4256288	0.1413422	3.011336	0.0026010	0.0059862	0.0026010	0.0030725	1.530552e+00	1.1602125	2.019105e+00	Abca8b	up
43	GDF10	GDF10	-0.3061819	0.1055962	-2.899555	0.0037369	0.0022250	0.0037369	0.0032660	7.362527e-01	0.5986090	9.055460e-01	Gdf10	up
44	GJA1	GJA1	-0.4050831	0.1380017	-2.935349	0.0033317	0.0035724	0.0033317	0.0034714	6.669214e-01	0.5088706	8.740613e-01	Gja1	up
29	CRTAC1	CRTAC1	-0.5539521	0.1912721	-2.896147	0.0037778	0.0040257	0.0037778	0.0037843	5.746742e-01	0.3950123	8.360510e-01	Crtac1	up
74	NRG3	NRG3	-2.4032161	0.8375289	-2.869413	0.0041123	0.0031459	0.0041123	0.0039243	9.042670e-02	0.0175142	4.668770e-01	Nrg3	up
123	TPSAB1	TPSAB1	-0.7426437	0.2748043	-2.702446	0.0068831	0.0004653	0.0068831	0.0039419	4.758542e-01	0.2776899	8.154320e-01	Tpsb2	down
128	TUB	TUB	-0.5196510	0.1808249	-2.873780	0.0040559	0.0047320	0.0040559	0.0041056	5.947281e-01	0.4172535	8.476897e-01	Tub	up
103	SFTPC	SFTPC	0.4223342	0.1487355	2.839498	0.0045185	0.0058762	0.0045185	0.0041667	1.525518e+00	1.1397603	2.041838e+00	Sftpc	up
120	TCHH	TCHH	-0.5988549	0.2142769	-2.794771	0.0051936	0.0025865	0.0051936	0.0050215	5.494404e-01	0.3610171	8.362064e-01	Tchh	up
130	VWC2	VWC2	-0.8118496	0.2985573	-2.719242	0.0065432	0.0042834	0.0065432	0.0057806	4.440360e-01	0.2473351	7.971695e-01	Vwc2	up
27	CNGA4	CNGA4	-1.0359853	0.3821171	-2.711172	0.0067046	0.0040296	0.0067046	0.0063590	3.548765e-01	0.1678103	7.504746e-01	Cnga4	up
114	SPHKAP	SPHKAP	-0.4625777	0.1721975	-2.686321	0.0072244	0.0065275	0.0072244	0.0068047	6.296585e-01	0.4492936	8.824291e-01	Sphkap	up
46	GLT8D2	GLT8D2	-1.6440659	0.6170412	-2.664435	0.0077118	0.0045787	0.0077118	0.0071151	1.931929e-01	0.0576454	6.474670e-01	Glt8d2	up
40	FAM186B	FAM186B	2.7648858	1.0270985	2.691938	0.0071038	0.0102688	0.0071038	0.0071928	1.587723e+01	2.1208349	1.188618e+02	Fam186b	up
5	ADCY2	ADCY2	-0.5091532	0.1915128	-2.658586	0.0078469	0.0086014	0.0078469	0.0075234	6.010043e-01	0.4129159	8.747693e-01	Adcy2	up
87	PLA2G4E	PLA2G4E	19.0823473	7.2463960	2.633357	0.0084545	0.0379296	0.0084545	0.0081310	1.938019e+08	131.5875091	2.854313e+14	Pla2g4e	up
96	RAB42	RAB42	0.5038644	0.1915025	2.631111	0.0085106	0.0086515	0.0085106	0.0084776	1.655105e+00	1.1371513	2.408978e+00	Rab42	up
73	NR3C2	NR3C2	-1.1889369	0.4523989	-2.628072	0.0085870	0.0066070	0.0085870	0.0085969	3.045449e-01	0.1254783	7.391523e-01	Nr3c2	up
60	LRRC18	LRRC18	0.8248612	0.3172093	2.600369	0.0093124	0.0202333	0.0093124	0.0094480	2.281564e+00	1.2252469	4.248560e+00	Lrrc18	up
66	MAP6D1	MAP6D1	0.3520670	0.1365555	2.578198	0.0099317	0.0104100	0.0099317	0.0094586	1.422004e+00	1.0880893	1.858390e+00	Map6d1	up
69	MGAT4C	MGAT4C	-1.3821722	0.5241332	-2.637063	0.0083627	0.0040005	0.0083627	0.0095399	2.510327e-01	0.0898643	7.012506e-01	Mgat4c	up
106	SLAIN2	SLAIN2	0.8455718	0.3292619	2.568083	0.0102263	0.0111327	0.0102263	0.0096223	2.329309e+00	1.2216841	4.441149e+00	Slain2	down
113	SPAG17	SPAG17	10.0872014	4.2371258	2.380671	0.0172812	0.0574988	0.0172812	0.0110288	2.403344e+04	5.9452191	9.715474e+07	Spag17	up
37	EFEMP1	EFEMP1	-0.2914440	0.1149583	-2.535214	0.0112379	0.0122232	0.0112379	0.0111204	7.471839e-01	0.5964510	9.360093e-01	Efemp1	up
12	CACNA2D2	CACNA2D2	-0.8043295	0.3205444	-2.509261	0.0120984	0.0098839	0.0120984	0.0118147	4.473878e-01	0.2386911	8.385559e-01	Cacna2d2	up
55	KLF14	KLF14	1.6071670	0.6370812	2.522703	0.0116457	0.0346226	0.0116457	0.0119965	4.988658e+00	1.4311964	1.738875e+01	Klf14	up
127	TTLL7	TTLL7	0.4510948	0.1808449	2.494374	0.0126179	0.0140847	0.0126179	0.0121624	1.570030e+00	1.1014697	2.237914e+00	Ttll7	up
28	CPA3	CPA3	-2.6676371	1.2839007	-2.077760	0.0377315	0.0010779	0.0377315	0.0122039	6.941610e-02	0.0056053	8.596431e-01	Cpa3	down
94	PRIMA1	PRIMA1	0.6222890	0.2488279	2.500881	0.0123885	0.0134312	0.0123885	0.0122378	1.863188e+00	1.1440737	3.034306e+00	Prima1	up
110	SLC7A11	SLC7A11	-0.5173928	0.2068672	-2.501087	0.0123813	0.0111473	0.0123813	0.0128561	5.960726e-01	0.3973869	8.940974e-01	Slc7a11	up
83	PDGFRA	PDGFRA	0.3197732	0.1282574	2.493214	0.0126593	0.0114151	0.0126593	0.0129613	1.376815e+00	1.0707863	1.770307e+00	Pdgfra	down
65	MAGEE2	MAGEE2	0.2072085	0.0847911	2.443752	0.0145354	0.0121291	0.0145354	0.0129998	1.230239e+00	1.0418739	1.452659e+00	Magee2	up
26	CLMN	CLMN	0.5914685	0.2374123	2.491314	0.0127272	0.0186262	0.0127272	0.0131366	1.806639e+00	1.1344511	2.877115e+00	Clmn	up
93	PPP2R2B	PPP2R2B	-0.7571162	0.3070699	-2.465615	0.0136778	0.0122080	0.0136778	0.0135049	4.690170e-01	0.2569273	8.561837e-01	Ppp2r2b	up
70	MSR1	MSR1	0.6293928	0.2584362	2.435390	0.0148758	0.0257520	0.0148758	0.0144026	1.876471e+00	1.1307343	3.114032e+00	Msr1	down
16	CCL27	CCL27	-10.1807420	4.9394362	-2.061114	0.0392921	0.0011244	0.0392921	0.0147958	3.790000e-05	0.0000000	6.067582e-01	Ccl27a	up
111	SLITRK5	SLITRK5	-0.4852339	0.1987193	-2.441806	0.0146140	0.0166802	0.0146140	0.0148097	6.155532e-01	0.4169802	9.086900e-01	Slitrk5	up
121	TFCP2L1	TFCP2L1	0.4640884	0.1932673	2.401277	0.0163379	0.0254705	0.0163379	0.0148488	1.590564e+00	1.0890344	2.323060e+00	Tfcp2l1	up
100	SCUBE3	SCUBE3	0.5114631	0.2125001	2.406884	0.0160893	0.0256815	0.0160893	0.0148709	1.667729e+00	1.0996264	2.529333e+00	Scube3	up
134	ZCCHC3	ZCCHC3	0.8449587	0.3501292	2.413277	0.0158098	0.0144719	0.0158098	0.0157013	2.327882e+00	1.1720075	4.623719e+00	Zcchc3	up
6	AHCYL2	AHCYL2	-0.4618186	0.1916865	-2.409239	0.0159858	0.0144949	0.0159858	0.0157534	6.301366e-01	0.4327837	9.174842e-01	Ahcyl2	up
84	PELI3	PELI3	-0.5361502	0.2219673	-2.415447	0.0157159	0.0125532	0.0157159	0.0158807	5.849960e-01	0.3786292	9.038405e-01	Peli3	up
117	SYT12	SYT12	-0.3974626	0.1658915	-2.395919	0.0165787	0.0103877	0.0165787	0.0161174	6.720231e-01	0.4854864	9.302320e-01	Syt12	up
61	LRRC6	LRRC6	-1.2100537	0.5083194	-2.380499	0.0172892	0.0148202	0.0172892	0.0162693	2.981813e-01	0.1101027	8.075373e-01	Lrrc6	up
77	OSR1	OSR1	0.2144682	0.0905432	2.368683	0.0178516	0.0251440	0.0178516	0.0166777	1.239203e+00	1.0377000	1.479834e+00	Osr1	up
90	PLK5	PLK5	-0.5414021	0.2291631	-2.362518	0.0181512	0.0166165	0.0181512	0.0175387	5.819318e-01	0.3713711	9.118766e-01	Plk5	up
59	LIX1	LIX1	-0.2840070	0.1205932	-2.355083	0.0185186	0.0237242	0.0185186	0.0177018	7.527614e-01	0.5943034	9.534687e-01	Lix1	up
45	GLRA3	GLRA3	-0.6180356	0.2634646	-2.345801	0.0189862	0.0133041	0.0189862	0.0185040	5.390022e-01	0.3216097	9.033416e-01	Glra3	up
71	NIPAL3	NIPAL3	0.3068599	0.1315510	2.332631	0.0196675	0.0202769	0.0196675	0.0189767	1.359150e+00	1.0502462	1.758911e+00	Nipal3	up
75	NSUN7	NSUN7	2.8988354	1.2476243	2.323484	0.0201532	0.0274793	0.0201532	0.0194083	1.815299e+01	1.5738687	2.093765e+02	Nsun7	up
3	ABLIM3	ABLIM3	-0.4204272	0.1804536	-2.329836	0.0198148	0.0196918	0.0198148	0.0196757	6.567662e-01	0.4611141	9.354340e-01	Ablim3	up
98	RNF32	RNF32	-0.7549155	0.3244026	-2.327095	0.0199602	0.0195812	0.0199602	0.0197767	4.700503e-01	0.2488928	8.877207e-01	Rnf32	up
30	CRYBB1	CRYBB1	-0.6109657	0.2598025	-2.351655	0.0186901	0.0162412	0.0186901	0.0199216	5.428264e-01	0.3262246	9.032443e-01	Crybb1	up
122	TNNI1	TNNI1	2.8923203	1.3335905	2.168822	0.0300962	0.0799377	0.0300962	0.0199732	1.803511e+01	1.3211876	2.461915e+02	Tnni1	up
91	POPDC3	POPDC3	0.3123546	0.1361879	2.293555	0.0218161	0.0284385	0.0218161	0.0201892	1.366639e+00	1.0464789	1.784749e+00	Popdc3	up
14	CAMSAP3	CAMSAP3	-0.2662145	0.1163447	-2.288152	0.0221286	0.0232764	0.0221286	0.0215514	7.662747e-01	0.6100307	9.625368e-01	Camsap3	up
42	FZD2	FZD2	0.3875964	0.1688566	2.295418	0.0217092	0.0214499	0.0217092	0.0216465	1.473435e+00	1.0582785	2.051455e+00	Fzd2	up
135	ZCCHC4	ZCCHC4	0.7571164	0.3109674	2.434713	0.0149036	0.0324878	0.0149036	0.0221649	2.132119e+00	1.1590857	3.921998e+00	Zcchc4	down
124	TPSB2	TPSB2	-0.4678065	0.2090684	-2.237576	0.0252487	0.0102559	0.0252487	0.0225107	6.263747e-01	0.4157908	9.436123e-01	Tpsb2	down
109	SLC4A4	SLC4A4	-0.4141597	0.1824616	-2.269846	0.0232169	0.0246088	0.0232169	0.0226269	6.608954e-01	0.4621906	9.450271e-01	Slc4a4	up
52	HTR2C	HTR2C	-3.1565775	1.3995778	-2.255378	0.0241096	0.0133067	0.0241096	0.0232918	4.257120e-02	0.0027403	6.613610e-01	Htr2c	up
108	SLC35F4	SLC35F4	6.9660928	3.4145385	2.040127	0.0413377	0.1207829	0.0413377	0.0234941	1.060073e+03	1.3148471	8.546653e+05	Slc35f4	up
39	FAM111A	FAM111A	0.4931808	0.2189509	2.252472	0.0242925	0.0261799	0.0242925	0.0238429	1.637517e+00	1.0661403	2.515110e+00	Fam111a	down
118	SYT17	SYT17	-0.6691720	0.2974328	-2.249826	0.0244600	0.0230309	0.0244600	0.0240354	5.121324e-01	0.2858953	9.173975e-01	Syt17	up
95	PROK2	PROK2	1.8148931	0.8212733	2.209853	0.0271154	0.0412250	0.0271154	0.0258169	6.140420e+00	1.2278037	3.070911e+01	Prok2	up
136	ZNF519	ZNF519	0.7099944	0.3196717	2.221011	0.0263502	0.0282681	0.0263502	0.0258965	2.033980e+00	1.0870303	3.805850e+00	Zfp941	up
92	PPIL6	PPIL6	-0.8190445	0.3663250	-2.235841	0.0253622	0.0228182	0.0253622	0.0262949	4.408527e-01	0.2150191	9.038782e-01	Ppil6	up
67	MEIG1	MEIG1	-1.4153405	0.6416480	-2.205790	0.0273987	0.0165410	0.0273987	0.0263250	2.428429e-01	0.0690484	8.540773e-01	Meig1	up
41	FRY	FRY	-0.6736747	0.3074954	-2.190845	0.0284630	0.0283663	0.0284630	0.0281425	5.098316e-01	0.2790527	9.314667e-01	Fry	up
24	CHST15	CHST15	-0.4167445	0.1902333	-2.190702	0.0284734	0.0278526	0.0284734	0.0281733	6.591893e-01	0.4540287	9.570553e-01	Chst15	up
19	CDH7	CDH7	-0.6616486	0.3054743	-2.165971	0.0303134	0.0216067	0.0303134	0.0286263	5.160000e-01	0.2835499	9.390093e-01	Cdh7	up
57	KNDC1	KNDC1	-0.2969632	0.1366881	-2.172560	0.0298134	0.0279141	0.0298134	0.0293196	7.430714e-01	0.5684358	9.713588e-01	Kndc1	up
125	TTC34	TTC34	-3.7733836	1.7457180	-2.161508	0.0306561	0.0235946	0.0306561	0.0297951	2.297420e-02	0.0007504	7.033933e-01	Ttc34	up
49	HHATL	HHATL	0.2470745	0.1144943	2.157963	0.0309307	0.0303280	0.0309307	0.0308650	1.280274e+00	1.0229287	1.602363e+00	Hhatl	up
53	KCNB1	KCNB1	-0.4829054	0.2251743	-2.144585	0.0319861	0.0281475	0.0319861	0.0316609	6.169882e-01	0.3968333	9.592804e-01	Kcnb1	up
51	HS6ST2	HS6ST2	0.8537621	0.4008883	2.129676	0.0331984	0.0357143	0.0331984	0.0317125	2.348466e+00	1.0704032	5.152535e+00	Hs6st2	up
126	TTLL11	TTLL11	1.3664702	0.6377193	2.142745	0.0321335	0.0412975	0.0321335	0.0321406	3.921484e+00	1.1236286	1.368605e+01	Ttll11	up
72	NLRP6	NLRP6	0.5442128	0.2548265	2.135621	0.0327103	0.0448962	0.0327103	0.0322133	1.723251e+00	1.0457789	2.839601e+00	Nlrp6	up
64	LUZP2	LUZP2	-0.3671389	0.1727341	-2.125457	0.0335485	0.0367364	0.0335485	0.0323780	6.927134e-01	0.4937670	9.718185e-01	Luzp2	up
10	BRINP1	BRINP1	-0.3392242	0.1600891	-2.118972	0.0340928	0.0305033	0.0340928	0.0324119	7.123227e-01	0.5204856	9.748658e-01	Brinp1	up
56	KLHDC9	KLHDC9	-0.2353128	0.1106619	-2.126413	0.0334689	0.0371299	0.0334689	0.0330566	7.903236e-01	0.6362230	9.817491e-01	Klhdc9	up
88	PLCB1	PLCB1	-0.6420079	0.3024846	-2.122448	0.0338001	0.0324093	0.0338001	0.0333069	5.262348e-01	0.2908735	9.520392e-01	Plcb1	up
105	SIDT1	SIDT1	-0.4174642	0.1983770	-2.104398	0.0353437	0.0278401	0.0353437	0.0339631	6.587150e-01	0.4465178	9.717541e-01	Sidt1	up
107	SLC1A2	SLC1A2	-0.2124443	0.1003561	-2.116904	0.0342680	0.0375824	0.0342680	0.0340428	8.086053e-01	0.6642221	9.843735e-01	Slc1a2	up
38	EMID1	EMID1	-0.4502308	0.2133506	-2.110287	0.0348337	0.0338802	0.0348337	0.0343860	6.374810e-01	0.4196265	9.684374e-01	Emid1	up
13	CACNA2D4	CACNA2D4	1.0245697	0.4891258	2.094696	0.0361980	0.0427101	0.0361980	0.0350024	2.785896e+00	1.0681207	7.266237e+00	Cacna2d4	up
76	NXPH3	NXPH3	-0.3774392	0.1806948	-2.088822	0.0367238	0.0409742	0.0367238	0.0363733	6.856149e-01	0.4811412	9.769850e-01	Nxph3	up
129	UNC13B	UNC13B	-0.7827685	0.3736143	-2.095125	0.0361599	0.0336327	0.0361599	0.0369294	4.571387e-01	0.2197996	9.507559e-01	Unc13b	up
132	WNT9A	WNT9A	0.6958626	0.3367280	2.066542	0.0387773	0.0463104	0.0387773	0.0378423	2.005438e+00	1.0365397	3.880008e+00	Wnt9a	up
112	SMIM1	SMIM1	0.5206950	0.2527491	2.060126	0.0393865	0.0428917	0.0393865	0.0385225	1.683197e+00	1.0256390	2.762329e+00	Smim1	up
9	BAIAP3	BAIAP3	-0.2794113	0.1351514	-2.067396	0.0386969	0.0418946	0.0386969	0.0390339	7.562288e-01	0.5802460	9.855853e-01	Baiap3	up
33	DMKN	DMKN	-0.3291229	0.1606125	-2.049173	0.0404452	0.0368210	0.0404452	0.0393216	7.195546e-01	0.5252307	9.857741e-01	Dmkn	up
115	SPRY3	SPRY3	0.4960903	0.2418322	2.051382	0.0402298	0.0386226	0.0402298	0.0404007	1.642288e+00	1.0223540	2.638136e+00	Spry3	up
2	ABHD3	ABHD3	0.5955091	0.2929307	2.032935	0.0420591	0.0407117	0.0420591	0.0409840	1.813954e+00	1.0216055	3.220842e+00	Abhd3	up
18	CD5L	CD5L	0.7754014	0.3848963	2.014572	0.0439495	0.1129359	0.0439495	0.0414056	2.171464e+00	1.0212410	4.617181e+00	Cd5l	down
58	LGI3	LGI3	0.1822722	0.0897599	2.030665	0.0422890	0.0443037	0.0422890	0.0414997	1.199941e+00	1.0063663	1.430749e+00	Lgi3	up
99	RSPO3	RSPO3	-0.6746499	0.3363098	-2.006037	0.0448523	0.0301619	0.0448523	0.0427121	5.093347e-01	0.2634728	9.846247e-01	Rspo3	up
32	DCHS2	DCHS2	-1.0486217	0.5210343	-2.012577	0.0441591	0.0349509	0.0441591	0.0427312	3.504204e-01	0.1262072	9.729591e-01	Dchs2	up
35	DNAH12	DNAH12	3.9025793	1.9420087	2.009558	0.0444780	0.0681526	0.0444780	0.0436603	4.953004e+01	1.1011029	2.227971e+03	Dnah12	up
31	CYB561	CYB561	-0.3508557	0.1754585	-1.999651	0.0455380	0.0350770	0.0455380	0.0445372	7.040854e-01	0.4992003	9.930608e-01	Cyb561	up
48	GPR176	GPR176	0.3455603	0.1729604	1.997916	0.0457257	0.0478815	0.0457257	0.0446132	1.412781e+00	1.0065858	1.982892e+00	Gpr176	up
34	DMRTC1	DMRTC1	98.5643120	49.8616264	1.976757	0.0480691	0.0630351	0.0480691	0.0448591	6.396418e+42	2.3101676	1.771047e+85	Dmrtc1a	up
116	SPTBN5	SPTBN5	0.6025659	0.3021065	1.994548	0.0460922	0.0585582	0.0460922	0.0449381	1.826800e+00	1.0105029	3.302513e+00	Sptbn5	up
8	ARPP21	ARPP21	-0.3743726	0.1867061	-2.005144	0.0449477	0.0462126	0.0449477	0.0451881	6.877206e-01	0.4769661	9.916001e-01	Arpp21	up
7	ALDOC	ALDOC	-0.2765491	0.1381129	-2.002341	0.0452480	0.0542366	0.0452480	0.0455496	7.583964e-01	0.5785413	9.941643e-01	Aldoc	up
23	CHST1	CHST1	-0.2144981	0.1081277	-1.983748	0.0472839	0.0521806	0.0472839	0.0467366	8.069463e-01	0.6528391	9.974316e-01	Chst1	up
131	WNT4	WNT4	-0.7042827	0.3598625	-1.957089	0.0503371	0.0247391	0.0503371	0.0469690	4.944631e-01	0.2442409	1.001035e+00	Wnt4	up
20	CDK6	CDK6	0.3824756	0.1938366	1.973185	0.0484744	0.0528413	0.0484744	0.0485995	1.465909e+00	1.0025661	2.143389e+00	Cdk6	down
97	RASGRF1	RASGRF1	-0.2693178	0.1370775	-1.964712	0.0494476	0.0439386	0.0494476	0.0487218	7.639004e-01	0.5839238	9.993493e-01	Rasgrf1	up
4	ADAMTS3	ADAMTS3	1.9769091	0.9586936	2.062086	0.0391995	0.0865033	0.0391995	0.0488657	7.220391e+00	1.1028571	4.727180e+01	Adamts3	up
119	SYT3	SYT3	-0.3410561	0.1739619	-1.960522	0.0499348	0.0391895	0.0499348	0.0489593	7.110190e-01	0.5055971	9.999029e-01	Syt3	up
81	PCDHGA4	PCDHGA4	1.0331251	0.5206786	1.984190	0.0472347	0.0638059	0.0472347	0.0497464	2.809833e+00	1.0126938	7.796199e+00	Pcdhga4	up
63	LSAMP	LSAMP	-0.6089189	0.3110885	-1.957382	0.0503026	0.0520013	0.0503026	0.0499826	5.439386e-01	0.2956316	1.000804e+00	Lsamp	up