Result

Analysis details

Demographic information

load("/mnt/data/lab/gmt_data/data_brain/gmt_analysis/compare_mouse_signatures_with_human/annotation_gbm_lgg_July2021.RData")
colnames(ann3)[1]<-"Samples"

annotation_mut<-ann3[ann3$type%in%"LGG" & (ann3$IDH1==1 | ann3$IDH2==1)  & (ann3$TP53==1 & ann3$ATRX==1),]
print(paste("The number of samples LGG with IDH*, TP53, ATRX is:",nrow(annotation_mut)))
## [1] "The number of samples LGG with IDH*, TP53, ATRX is: 164"
annotation_only_idh<-ann3[ann3$type%in%"LGG" & (ann3$IDH1==1 | ann3$IDH2==1),]
print(paste("The number of samples LGG with IDH* is:",nrow(annotation_only_idh)))
## [1] "The number of samples LGG with IDH* is: 411"
annotation_gbm_lgg<-ann3
print(paste("The number of samples LGG  and GBM:",nrow(annotation_gbm_lgg)))
## [1] "The number of samples LGG  and GBM: 794"
annotation_idh_codel_nocodel<-ann3[ann3$type%in%"LGG" & (ann3$IDH_codel_subtype=="IDHmut-codel" | ann3$IDH_codel_subtype=="IDHmut-non-codel"),]
print(paste("The number of samples LGG IDHmut-codel and IDHmut-non-codel is:",nrow(annotation_idh_codel_nocodel)))
## [1] "The number of samples LGG IDHmut-codel and IDHmut-non-codel is: 414"
annotation_idh_codel<-ann3[ann3$type%in%"LGG" & (ann3$IDH_codel_subtype=="IDHmut-codel"),]
print(paste("The number of samples LGG with IDHmut-codel is:",nrow(annotation_idh_codel)))
## [1] "The number of samples LGG with IDHmut-codel is: 169"
annotation_idh_nocodel<-ann3[ann3$type%in%"LGG" & (ann3$IDH_codel_subtype=="IDHmut-non-codel"),]
print(paste("The number of samples LGG with IDHmut-non-codel is:",nrow(annotation_idh_nocodel)))
## [1] "The number of samples LGG with IDHmut-non-codel is: 245"
annotation_gbm_only<-ann3[ann3$type%in%"GBM",]
print(paste("The number of samples GBM is:",nrow(annotation_gbm_only)))
## [1] "The number of samples GBM is: 285"

Analysis

  • Step1: Select the genes with cox proportional hazard models in IDH_NOCODEL (logRank p-value < 0.05)
  • Step2: Select a group of samples (e.g. IDH*/TP53/ATRX)
  • Step3: Consider different tresholds of logRank 0.01,0.001,0.05
  • Step4: Select the genes according with Step3
  • Step5: Compute the gsva scores (default parameters) using 1) up and down genes 2) only up 3) only down
  • Step6: If there is a sufficent number of genes, compute the difference between the scores computed using the up-regulated genes and down-regulated genes (up-down) (C1A is the numerator). This whati I call “global_score”.
  • Step7: The stratification of the samples is perfomed using 0 as cut-off value to distinguish (MCP). The classification are stored in a column (“status_C1AC1B”).
  • Step8: Plot the Kaplan Meier curve with the overall survival as outcome
  • Step9: Use surv_cutpoint and column global_score to define automatically a cut-point for the groups

FAQ report

  • The order of the rows is based on the logRank cut-off (0.05, 0.01, 0.01)
  • First column: overall survival using manual cut-point (0) see Step7
  • Second-third columns: results surv_cutpoint
  • Second-third columns: results surv_cutpoint
  • Table-genes: results of cox proportional hazard model with IDH_NOCODEL samples (logRank p-value < 0.05). Use column logRank to select the genes.

IDH TRIPLE MUT

UP and DOWN

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UP

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DOWN

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Table genes

Variable Term Beta StandardError Z P LRT Wald LogRank HR HRlower HRupper mm status
47 GPR139 GPR139 2.9954716 0.5459944 5.486268 0.0000000 0.0000008 0.0000000 0.0000000 1.999479e+01 6.8574946 5.829993e+01 Gpr139 up
11 BVES BVES 0.7842063 0.1424517 5.505070 0.0000000 0.0000025 0.0000000 0.0000001 2.190667e+00 1.6569958 2.896220e+00 Bves up
22 CHIC2 CHIC2 1.1744777 0.2267115 5.180495 0.0000002 0.0000079 0.0000002 0.0000002 3.236452e+00 2.0753531 5.047152e+00 Chic2 down
62 LRRK2 LRRK2 0.6724442 0.1341983 5.010825 0.0000005 0.0000059 0.0000005 0.0000002 1.959020e+00 1.5059447 2.548406e+00 Lrrk2 up
21 CEP135 CEP135 1.1901584 0.2479228 4.800520 0.0000016 0.0000491 0.0000016 0.0000014 3.287602e+00 2.0223064 5.344554e+00 Cep135 down
133 ZBTB8B ZBTB8B 1.1045218 0.2349319 4.701455 0.0000026 0.0000192 0.0000026 0.0000022 3.017781e+00 1.9042034 4.782579e+00 Zbtb8b up
86 PI4K2B PI4K2B 1.0371524 0.2498474 4.151143 0.0000331 0.0015532 0.0000331 0.0000217 2.821172e+00 1.7288568 4.603626e+00 Pi4k2b down
102 SERINC2 SERINC2 0.6263722 0.1610620 3.889012 0.0001007 0.0002453 0.0001007 0.0000827 1.870811e+00 1.3643749 2.565230e+00 Serinc2 up
104 SH3GL2 SH3GL2 -0.7907620 0.2005988 -3.942008 0.0000808 0.0000695 0.0000808 0.0001115 4.534991e-01 0.3060740 6.719337e-01 Sh3gl2 up
15 CCDC87 CCDC87 -0.7788043 0.2036870 -3.823535 0.0001316 0.0001516 0.0001316 0.0001223 4.589545e-01 0.3078867 6.841452e-01 Ccdc87 up
80 PCDHGA3 PCDHGA3 0.6336887 0.1854916 3.416266 0.0006349 0.0047731 0.0006349 0.0001990 1.884549e+00 1.3101371 2.710805e+00 Pcdhga3 up
101 SEPSECS SEPSECS 1.0745060 0.2684215 4.003055 0.0000625 0.0004790 0.0000625 0.0002610 2.928546e+00 1.7304985 4.956017e+00 Sepsecs down
78 PAX5 PAX5 4.3732708 1.3013911 3.360458 0.0007781 0.0111408 0.0007781 0.0002911 7.930259e+01 6.1878707 1.016327e+03 Pax5 down
54 KCNG1 KCNG1 -0.5347163 0.1540201 -3.471731 0.0005171 0.0001938 0.0005171 0.0004520 5.858355e-01 0.4331851 7.922784e-01 Kcng1 up
85 PHKG1 PHKG1 -0.3998301 0.1165522 -3.430480 0.0006025 0.0009269 0.0006025 0.0004617 6.704339e-01 0.5335149 8.424913e-01 Phkg1 up
50 HHIP HHIP 0.5367070 0.1575686 3.406179 0.0006588 0.0014311 0.0006588 0.0005304 1.710365e+00 1.2559323 2.329225e+00 Hhip up
36 EFCAB6 EFCAB6 -7.0065194 2.0604116 -3.400543 0.0006725 0.0002490 0.0006725 0.0005886 9.060000e-04 0.0000160 5.139640e-02 Efcab6 up
68 METTL11B METTL11B 2.6216611 0.8373169 3.131026 0.0017420 0.0097680 0.0017420 0.0007621 1.375856e+01 2.6659224 7.100655e+01 Mettl11b up
89 PLCXD1 PLCXD1 0.6979770 0.2051305 3.402601 0.0006675 0.0009493 0.0006675 0.0007977 2.009683e+00 1.3443743 3.004242e+00 Plcxd1 up
25 CLEC18A CLEC18A 2.0090652 0.6175386 3.253344 0.0011406 0.0037224 0.0011406 0.0009366 7.456344e+00 2.2226761 2.501357e+01 Clec18a up
82 PCDHGA8 PCDHGA8 4.5064285 1.4663795 3.073167 0.0021180 0.0114419 0.0021180 0.0016940 9.059767e+01 5.1160230 1.604359e+03 Pcdhga8 up
79 PCDH7 PCDH7 -0.7147787 0.2368258 -3.018163 0.0025431 0.0019136 0.0025431 0.0024481 4.893004e-01 0.3076020 7.783268e-01 Pcdh7 up
17 CCNB2 CCNB2 0.3221457 0.1089420 2.957039 0.0031061 0.0046368 0.0031061 0.0027830 1.380086e+00 1.1147424 1.708589e+00 Ccnb2 down
1 ABCA8 ABCA8 0.4256288 0.1413422 3.011336 0.0026010 0.0059862 0.0026010 0.0030725 1.530552e+00 1.1602125 2.019105e+00 Abca8b up
43 GDF10 GDF10 -0.3061819 0.1055962 -2.899555 0.0037369 0.0022250 0.0037369 0.0032660 7.362527e-01 0.5986090 9.055460e-01 Gdf10 up
44 GJA1 GJA1 -0.4050831 0.1380017 -2.935349 0.0033317 0.0035724 0.0033317 0.0034714 6.669214e-01 0.5088706 8.740613e-01 Gja1 up
29 CRTAC1 CRTAC1 -0.5539521 0.1912721 -2.896147 0.0037778 0.0040257 0.0037778 0.0037843 5.746742e-01 0.3950123 8.360510e-01 Crtac1 up
74 NRG3 NRG3 -2.4032161 0.8375289 -2.869413 0.0041123 0.0031459 0.0041123 0.0039243 9.042670e-02 0.0175142 4.668770e-01 Nrg3 up
123 TPSAB1 TPSAB1 -0.7426437 0.2748043 -2.702446 0.0068831 0.0004653 0.0068831 0.0039419 4.758542e-01 0.2776899 8.154320e-01 Tpsb2 down
128 TUB TUB -0.5196510 0.1808249 -2.873780 0.0040559 0.0047320 0.0040559 0.0041056 5.947281e-01 0.4172535 8.476897e-01 Tub up
103 SFTPC SFTPC 0.4223342 0.1487355 2.839498 0.0045185 0.0058762 0.0045185 0.0041667 1.525518e+00 1.1397603 2.041838e+00 Sftpc up
120 TCHH TCHH -0.5988549 0.2142769 -2.794771 0.0051936 0.0025865 0.0051936 0.0050215 5.494404e-01 0.3610171 8.362064e-01 Tchh up
130 VWC2 VWC2 -0.8118496 0.2985573 -2.719242 0.0065432 0.0042834 0.0065432 0.0057806 4.440360e-01 0.2473351 7.971695e-01 Vwc2 up
27 CNGA4 CNGA4 -1.0359853 0.3821171 -2.711172 0.0067046 0.0040296 0.0067046 0.0063590 3.548765e-01 0.1678103 7.504746e-01 Cnga4 up
114 SPHKAP SPHKAP -0.4625777 0.1721975 -2.686321 0.0072244 0.0065275 0.0072244 0.0068047 6.296585e-01 0.4492936 8.824291e-01 Sphkap up
46 GLT8D2 GLT8D2 -1.6440659 0.6170412 -2.664435 0.0077118 0.0045787 0.0077118 0.0071151 1.931929e-01 0.0576454 6.474670e-01 Glt8d2 up
40 FAM186B FAM186B 2.7648858 1.0270985 2.691938 0.0071038 0.0102688 0.0071038 0.0071928 1.587723e+01 2.1208349 1.188618e+02 Fam186b up
5 ADCY2 ADCY2 -0.5091532 0.1915128 -2.658586 0.0078469 0.0086014 0.0078469 0.0075234 6.010043e-01 0.4129159 8.747693e-01 Adcy2 up
87 PLA2G4E PLA2G4E 19.0823473 7.2463960 2.633357 0.0084545 0.0379296 0.0084545 0.0081310 1.938019e+08 131.5875091 2.854313e+14 Pla2g4e up
96 RAB42 RAB42 0.5038644 0.1915025 2.631111 0.0085106 0.0086515 0.0085106 0.0084776 1.655105e+00 1.1371513 2.408978e+00 Rab42 up
73 NR3C2 NR3C2 -1.1889369 0.4523989 -2.628072 0.0085870 0.0066070 0.0085870 0.0085969 3.045449e-01 0.1254783 7.391523e-01 Nr3c2 up
60 LRRC18 LRRC18 0.8248612 0.3172093 2.600369 0.0093124 0.0202333 0.0093124 0.0094480 2.281564e+00 1.2252469 4.248560e+00 Lrrc18 up
66 MAP6D1 MAP6D1 0.3520670 0.1365555 2.578198 0.0099317 0.0104100 0.0099317 0.0094586 1.422004e+00 1.0880893 1.858390e+00 Map6d1 up
69 MGAT4C MGAT4C -1.3821722 0.5241332 -2.637063 0.0083627 0.0040005 0.0083627 0.0095399 2.510327e-01 0.0898643 7.012506e-01 Mgat4c up
106 SLAIN2 SLAIN2 0.8455718 0.3292619 2.568083 0.0102263 0.0111327 0.0102263 0.0096223 2.329309e+00 1.2216841 4.441149e+00 Slain2 down
113 SPAG17 SPAG17 10.0872014 4.2371258 2.380671 0.0172812 0.0574988 0.0172812 0.0110288 2.403344e+04 5.9452191 9.715474e+07 Spag17 up
37 EFEMP1 EFEMP1 -0.2914440 0.1149583 -2.535214 0.0112379 0.0122232 0.0112379 0.0111204 7.471839e-01 0.5964510 9.360093e-01 Efemp1 up
12 CACNA2D2 CACNA2D2 -0.8043295 0.3205444 -2.509261 0.0120984 0.0098839 0.0120984 0.0118147 4.473878e-01 0.2386911 8.385559e-01 Cacna2d2 up
55 KLF14 KLF14 1.6071670 0.6370812 2.522703 0.0116457 0.0346226 0.0116457 0.0119965 4.988658e+00 1.4311964 1.738875e+01 Klf14 up
127 TTLL7 TTLL7 0.4510948 0.1808449 2.494374 0.0126179 0.0140847 0.0126179 0.0121624 1.570030e+00 1.1014697 2.237914e+00 Ttll7 up
28 CPA3 CPA3 -2.6676371 1.2839007 -2.077760 0.0377315 0.0010779 0.0377315 0.0122039 6.941610e-02 0.0056053 8.596431e-01 Cpa3 down
94 PRIMA1 PRIMA1 0.6222890 0.2488279 2.500881 0.0123885 0.0134312 0.0123885 0.0122378 1.863188e+00 1.1440737 3.034306e+00 Prima1 up
110 SLC7A11 SLC7A11 -0.5173928 0.2068672 -2.501087 0.0123813 0.0111473 0.0123813 0.0128561 5.960726e-01 0.3973869 8.940974e-01 Slc7a11 up
83 PDGFRA PDGFRA 0.3197732 0.1282574 2.493214 0.0126593 0.0114151 0.0126593 0.0129613 1.376815e+00 1.0707863 1.770307e+00 Pdgfra down
65 MAGEE2 MAGEE2 0.2072085 0.0847911 2.443752 0.0145354 0.0121291 0.0145354 0.0129998 1.230239e+00 1.0418739 1.452659e+00 Magee2 up
26 CLMN CLMN 0.5914685 0.2374123 2.491314 0.0127272 0.0186262 0.0127272 0.0131366 1.806639e+00 1.1344511 2.877115e+00 Clmn up
93 PPP2R2B PPP2R2B -0.7571162 0.3070699 -2.465615 0.0136778 0.0122080 0.0136778 0.0135049 4.690170e-01 0.2569273 8.561837e-01 Ppp2r2b up
70 MSR1 MSR1 0.6293928 0.2584362 2.435390 0.0148758 0.0257520 0.0148758 0.0144026 1.876471e+00 1.1307343 3.114032e+00 Msr1 down
16 CCL27 CCL27 -10.1807420 4.9394362 -2.061114 0.0392921 0.0011244 0.0392921 0.0147958 3.790000e-05 0.0000000 6.067582e-01 Ccl27a up
111 SLITRK5 SLITRK5 -0.4852339 0.1987193 -2.441806 0.0146140 0.0166802 0.0146140 0.0148097 6.155532e-01 0.4169802 9.086900e-01 Slitrk5 up
121 TFCP2L1 TFCP2L1 0.4640884 0.1932673 2.401277 0.0163379 0.0254705 0.0163379 0.0148488 1.590564e+00 1.0890344 2.323060e+00 Tfcp2l1 up
100 SCUBE3 SCUBE3 0.5114631 0.2125001 2.406884 0.0160893 0.0256815 0.0160893 0.0148709 1.667729e+00 1.0996264 2.529333e+00 Scube3 up
134 ZCCHC3 ZCCHC3 0.8449587 0.3501292 2.413277 0.0158098 0.0144719 0.0158098 0.0157013 2.327882e+00 1.1720075 4.623719e+00 Zcchc3 up
6 AHCYL2 AHCYL2 -0.4618186 0.1916865 -2.409239 0.0159858 0.0144949 0.0159858 0.0157534 6.301366e-01 0.4327837 9.174842e-01 Ahcyl2 up
84 PELI3 PELI3 -0.5361502 0.2219673 -2.415447 0.0157159 0.0125532 0.0157159 0.0158807 5.849960e-01 0.3786292 9.038405e-01 Peli3 up
117 SYT12 SYT12 -0.3974626 0.1658915 -2.395919 0.0165787 0.0103877 0.0165787 0.0161174 6.720231e-01 0.4854864 9.302320e-01 Syt12 up
61 LRRC6 LRRC6 -1.2100537 0.5083194 -2.380499 0.0172892 0.0148202 0.0172892 0.0162693 2.981813e-01 0.1101027 8.075373e-01 Lrrc6 up
77 OSR1 OSR1 0.2144682 0.0905432 2.368683 0.0178516 0.0251440 0.0178516 0.0166777 1.239203e+00 1.0377000 1.479834e+00 Osr1 up
90 PLK5 PLK5 -0.5414021 0.2291631 -2.362518 0.0181512 0.0166165 0.0181512 0.0175387 5.819318e-01 0.3713711 9.118766e-01 Plk5 up
59 LIX1 LIX1 -0.2840070 0.1205932 -2.355083 0.0185186 0.0237242 0.0185186 0.0177018 7.527614e-01 0.5943034 9.534687e-01 Lix1 up
45 GLRA3 GLRA3 -0.6180356 0.2634646 -2.345801 0.0189862 0.0133041 0.0189862 0.0185040 5.390022e-01 0.3216097 9.033416e-01 Glra3 up
71 NIPAL3 NIPAL3 0.3068599 0.1315510 2.332631 0.0196675 0.0202769 0.0196675 0.0189767 1.359150e+00 1.0502462 1.758911e+00 Nipal3 up
75 NSUN7 NSUN7 2.8988354 1.2476243 2.323484 0.0201532 0.0274793 0.0201532 0.0194083 1.815299e+01 1.5738687 2.093765e+02 Nsun7 up
3 ABLIM3 ABLIM3 -0.4204272 0.1804536 -2.329836 0.0198148 0.0196918 0.0198148 0.0196757 6.567662e-01 0.4611141 9.354340e-01 Ablim3 up
98 RNF32 RNF32 -0.7549155 0.3244026 -2.327095 0.0199602 0.0195812 0.0199602 0.0197767 4.700503e-01 0.2488928 8.877207e-01 Rnf32 up
30 CRYBB1 CRYBB1 -0.6109657 0.2598025 -2.351655 0.0186901 0.0162412 0.0186901 0.0199216 5.428264e-01 0.3262246 9.032443e-01 Crybb1 up
122 TNNI1 TNNI1 2.8923203 1.3335905 2.168822 0.0300962 0.0799377 0.0300962 0.0199732 1.803511e+01 1.3211876 2.461915e+02 Tnni1 up
91 POPDC3 POPDC3 0.3123546 0.1361879 2.293555 0.0218161 0.0284385 0.0218161 0.0201892 1.366639e+00 1.0464789 1.784749e+00 Popdc3 up
14 CAMSAP3 CAMSAP3 -0.2662145 0.1163447 -2.288152 0.0221286 0.0232764 0.0221286 0.0215514 7.662747e-01 0.6100307 9.625368e-01 Camsap3 up
42 FZD2 FZD2 0.3875964 0.1688566 2.295418 0.0217092 0.0214499 0.0217092 0.0216465 1.473435e+00 1.0582785 2.051455e+00 Fzd2 up
135 ZCCHC4 ZCCHC4 0.7571164 0.3109674 2.434713 0.0149036 0.0324878 0.0149036 0.0221649 2.132119e+00 1.1590857 3.921998e+00 Zcchc4 down
124 TPSB2 TPSB2 -0.4678065 0.2090684 -2.237576 0.0252487 0.0102559 0.0252487 0.0225107 6.263747e-01 0.4157908 9.436123e-01 Tpsb2 down
109 SLC4A4 SLC4A4 -0.4141597 0.1824616 -2.269846 0.0232169 0.0246088 0.0232169 0.0226269 6.608954e-01 0.4621906 9.450271e-01 Slc4a4 up
52 HTR2C HTR2C -3.1565775 1.3995778 -2.255378 0.0241096 0.0133067 0.0241096 0.0232918 4.257120e-02 0.0027403 6.613610e-01 Htr2c up
108 SLC35F4 SLC35F4 6.9660928 3.4145385 2.040127 0.0413377 0.1207829 0.0413377 0.0234941 1.060073e+03 1.3148471 8.546653e+05 Slc35f4 up
39 FAM111A FAM111A 0.4931808 0.2189509 2.252472 0.0242925 0.0261799 0.0242925 0.0238429 1.637517e+00 1.0661403 2.515110e+00 Fam111a down
118 SYT17 SYT17 -0.6691720 0.2974328 -2.249826 0.0244600 0.0230309 0.0244600 0.0240354 5.121324e-01 0.2858953 9.173975e-01 Syt17 up
95 PROK2 PROK2 1.8148931 0.8212733 2.209853 0.0271154 0.0412250 0.0271154 0.0258169 6.140420e+00 1.2278037 3.070911e+01 Prok2 up
136 ZNF519 ZNF519 0.7099944 0.3196717 2.221011 0.0263502 0.0282681 0.0263502 0.0258965 2.033980e+00 1.0870303 3.805850e+00 Zfp941 up
92 PPIL6 PPIL6 -0.8190445 0.3663250 -2.235841 0.0253622 0.0228182 0.0253622 0.0262949 4.408527e-01 0.2150191 9.038782e-01 Ppil6 up
67 MEIG1 MEIG1 -1.4153405 0.6416480 -2.205790 0.0273987 0.0165410 0.0273987 0.0263250 2.428429e-01 0.0690484 8.540773e-01 Meig1 up
41 FRY FRY -0.6736747 0.3074954 -2.190845 0.0284630 0.0283663 0.0284630 0.0281425 5.098316e-01 0.2790527 9.314667e-01 Fry up
24 CHST15 CHST15 -0.4167445 0.1902333 -2.190702 0.0284734 0.0278526 0.0284734 0.0281733 6.591893e-01 0.4540287 9.570553e-01 Chst15 up
19 CDH7 CDH7 -0.6616486 0.3054743 -2.165971 0.0303134 0.0216067 0.0303134 0.0286263 5.160000e-01 0.2835499 9.390093e-01 Cdh7 up
57 KNDC1 KNDC1 -0.2969632 0.1366881 -2.172560 0.0298134 0.0279141 0.0298134 0.0293196 7.430714e-01 0.5684358 9.713588e-01 Kndc1 up
125 TTC34 TTC34 -3.7733836 1.7457180 -2.161508 0.0306561 0.0235946 0.0306561 0.0297951 2.297420e-02 0.0007504 7.033933e-01 Ttc34 up
49 HHATL HHATL 0.2470745 0.1144943 2.157963 0.0309307 0.0303280 0.0309307 0.0308650 1.280274e+00 1.0229287 1.602363e+00 Hhatl up
53 KCNB1 KCNB1 -0.4829054 0.2251743 -2.144585 0.0319861 0.0281475 0.0319861 0.0316609 6.169882e-01 0.3968333 9.592804e-01 Kcnb1 up
51 HS6ST2 HS6ST2 0.8537621 0.4008883 2.129676 0.0331984 0.0357143 0.0331984 0.0317125 2.348466e+00 1.0704032 5.152535e+00 Hs6st2 up
126 TTLL11 TTLL11 1.3664702 0.6377193 2.142745 0.0321335 0.0412975 0.0321335 0.0321406 3.921484e+00 1.1236286 1.368605e+01 Ttll11 up
72 NLRP6 NLRP6 0.5442128 0.2548265 2.135621 0.0327103 0.0448962 0.0327103 0.0322133 1.723251e+00 1.0457789 2.839601e+00 Nlrp6 up
64 LUZP2 LUZP2 -0.3671389 0.1727341 -2.125457 0.0335485 0.0367364 0.0335485 0.0323780 6.927134e-01 0.4937670 9.718185e-01 Luzp2 up
10 BRINP1 BRINP1 -0.3392242 0.1600891 -2.118972 0.0340928 0.0305033 0.0340928 0.0324119 7.123227e-01 0.5204856 9.748658e-01 Brinp1 up
56 KLHDC9 KLHDC9 -0.2353128 0.1106619 -2.126413 0.0334689 0.0371299 0.0334689 0.0330566 7.903236e-01 0.6362230 9.817491e-01 Klhdc9 up
88 PLCB1 PLCB1 -0.6420079 0.3024846 -2.122448 0.0338001 0.0324093 0.0338001 0.0333069 5.262348e-01 0.2908735 9.520392e-01 Plcb1 up
105 SIDT1 SIDT1 -0.4174642 0.1983770 -2.104398 0.0353437 0.0278401 0.0353437 0.0339631 6.587150e-01 0.4465178 9.717541e-01 Sidt1 up
107 SLC1A2 SLC1A2 -0.2124443 0.1003561 -2.116904 0.0342680 0.0375824 0.0342680 0.0340428 8.086053e-01 0.6642221 9.843735e-01 Slc1a2 up
38 EMID1 EMID1 -0.4502308 0.2133506 -2.110287 0.0348337 0.0338802 0.0348337 0.0343860 6.374810e-01 0.4196265 9.684374e-01 Emid1 up
13 CACNA2D4 CACNA2D4 1.0245697 0.4891258 2.094696 0.0361980 0.0427101 0.0361980 0.0350024 2.785896e+00 1.0681207 7.266237e+00 Cacna2d4 up
76 NXPH3 NXPH3 -0.3774392 0.1806948 -2.088822 0.0367238 0.0409742 0.0367238 0.0363733 6.856149e-01 0.4811412 9.769850e-01 Nxph3 up
129 UNC13B UNC13B -0.7827685 0.3736143 -2.095125 0.0361599 0.0336327 0.0361599 0.0369294 4.571387e-01 0.2197996 9.507559e-01 Unc13b up
132 WNT9A WNT9A 0.6958626 0.3367280 2.066542 0.0387773 0.0463104 0.0387773 0.0378423 2.005438e+00 1.0365397 3.880008e+00 Wnt9a up
112 SMIM1 SMIM1 0.5206950 0.2527491 2.060126 0.0393865 0.0428917 0.0393865 0.0385225 1.683197e+00 1.0256390 2.762329e+00 Smim1 up
9 BAIAP3 BAIAP3 -0.2794113 0.1351514 -2.067396 0.0386969 0.0418946 0.0386969 0.0390339 7.562288e-01 0.5802460 9.855853e-01 Baiap3 up
33 DMKN DMKN -0.3291229 0.1606125 -2.049173 0.0404452 0.0368210 0.0404452 0.0393216 7.195546e-01 0.5252307 9.857741e-01 Dmkn up
115 SPRY3 SPRY3 0.4960903 0.2418322 2.051382 0.0402298 0.0386226 0.0402298 0.0404007 1.642288e+00 1.0223540 2.638136e+00 Spry3 up
2 ABHD3 ABHD3 0.5955091 0.2929307 2.032935 0.0420591 0.0407117 0.0420591 0.0409840 1.813954e+00 1.0216055 3.220842e+00 Abhd3 up
18 CD5L CD5L 0.7754014 0.3848963 2.014572 0.0439495 0.1129359 0.0439495 0.0414056 2.171464e+00 1.0212410 4.617181e+00 Cd5l down
58 LGI3 LGI3 0.1822722 0.0897599 2.030665 0.0422890 0.0443037 0.0422890 0.0414997 1.199941e+00 1.0063663 1.430749e+00 Lgi3 up
99 RSPO3 RSPO3 -0.6746499 0.3363098 -2.006037 0.0448523 0.0301619 0.0448523 0.0427121 5.093347e-01 0.2634728 9.846247e-01 Rspo3 up
32 DCHS2 DCHS2 -1.0486217 0.5210343 -2.012577 0.0441591 0.0349509 0.0441591 0.0427312 3.504204e-01 0.1262072 9.729591e-01 Dchs2 up
35 DNAH12 DNAH12 3.9025793 1.9420087 2.009558 0.0444780 0.0681526 0.0444780 0.0436603 4.953004e+01 1.1011029 2.227971e+03 Dnah12 up
31 CYB561 CYB561 -0.3508557 0.1754585 -1.999651 0.0455380 0.0350770 0.0455380 0.0445372 7.040854e-01 0.4992003 9.930608e-01 Cyb561 up
48 GPR176 GPR176 0.3455603 0.1729604 1.997916 0.0457257 0.0478815 0.0457257 0.0446132 1.412781e+00 1.0065858 1.982892e+00 Gpr176 up
34 DMRTC1 DMRTC1 98.5643120 49.8616264 1.976757 0.0480691 0.0630351 0.0480691 0.0448591 6.396418e+42 2.3101676 1.771047e+85 Dmrtc1a up
116 SPTBN5 SPTBN5 0.6025659 0.3021065 1.994548 0.0460922 0.0585582 0.0460922 0.0449381 1.826800e+00 1.0105029 3.302513e+00 Sptbn5 up
8 ARPP21 ARPP21 -0.3743726 0.1867061 -2.005144 0.0449477 0.0462126 0.0449477 0.0451881 6.877206e-01 0.4769661 9.916001e-01 Arpp21 up
7 ALDOC ALDOC -0.2765491 0.1381129 -2.002341 0.0452480 0.0542366 0.0452480 0.0455496 7.583964e-01 0.5785413 9.941643e-01 Aldoc up
23 CHST1 CHST1 -0.2144981 0.1081277 -1.983748 0.0472839 0.0521806 0.0472839 0.0467366 8.069463e-01 0.6528391 9.974316e-01 Chst1 up
131 WNT4 WNT4 -0.7042827 0.3598625 -1.957089 0.0503371 0.0247391 0.0503371 0.0469690 4.944631e-01 0.2442409 1.001035e+00 Wnt4 up
20 CDK6 CDK6 0.3824756 0.1938366 1.973185 0.0484744 0.0528413 0.0484744 0.0485995 1.465909e+00 1.0025661 2.143389e+00 Cdk6 down
97 RASGRF1 RASGRF1 -0.2693178 0.1370775 -1.964712 0.0494476 0.0439386 0.0494476 0.0487218 7.639004e-01 0.5839238 9.993493e-01 Rasgrf1 up
4 ADAMTS3 ADAMTS3 1.9769091 0.9586936 2.062086 0.0391995 0.0865033 0.0391995 0.0488657 7.220391e+00 1.1028571 4.727180e+01 Adamts3 up
119 SYT3 SYT3 -0.3410561 0.1739619 -1.960522 0.0499348 0.0391895 0.0499348 0.0489593 7.110190e-01 0.5055971 9.999029e-01 Syt3 up
81 PCDHGA4 PCDHGA4 1.0331251 0.5206786 1.984190 0.0472347 0.0638059 0.0472347 0.0497464 2.809833e+00 1.0126938 7.796199e+00 Pcdhga4 up
63 LSAMP LSAMP -0.6089189 0.3110885 -1.957382 0.0503026 0.0520013 0.0503026 0.0499826 5.439386e-01 0.2956316 1.000804e+00 Lsamp up

ONLY IDH

Gene-sets considered

UP and DOWN

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Table genes

Variable Term Beta StandardError Z P LRT Wald LogRank HR HRlower HRupper mm status
47 GPR139 GPR139 2.9954716 0.5459944 5.486268 0.0000000 0.0000008 0.0000000 0.0000000 1.999479e+01 6.8574946 5.829993e+01 Gpr139 up
11 BVES BVES 0.7842063 0.1424517 5.505070 0.0000000 0.0000025 0.0000000 0.0000001 2.190667e+00 1.6569958 2.896220e+00 Bves up
22 CHIC2 CHIC2 1.1744777 0.2267115 5.180495 0.0000002 0.0000079 0.0000002 0.0000002 3.236452e+00 2.0753531 5.047152e+00 Chic2 down
62 LRRK2 LRRK2 0.6724442 0.1341983 5.010825 0.0000005 0.0000059 0.0000005 0.0000002 1.959020e+00 1.5059447 2.548406e+00 Lrrk2 up
21 CEP135 CEP135 1.1901584 0.2479228 4.800520 0.0000016 0.0000491 0.0000016 0.0000014 3.287602e+00 2.0223064 5.344554e+00 Cep135 down
133 ZBTB8B ZBTB8B 1.1045218 0.2349319 4.701455 0.0000026 0.0000192 0.0000026 0.0000022 3.017781e+00 1.9042034 4.782579e+00 Zbtb8b up
86 PI4K2B PI4K2B 1.0371524 0.2498474 4.151143 0.0000331 0.0015532 0.0000331 0.0000217 2.821172e+00 1.7288568 4.603626e+00 Pi4k2b down
102 SERINC2 SERINC2 0.6263722 0.1610620 3.889012 0.0001007 0.0002453 0.0001007 0.0000827 1.870811e+00 1.3643749 2.565230e+00 Serinc2 up
104 SH3GL2 SH3GL2 -0.7907620 0.2005988 -3.942008 0.0000808 0.0000695 0.0000808 0.0001115 4.534991e-01 0.3060740 6.719337e-01 Sh3gl2 up
15 CCDC87 CCDC87 -0.7788043 0.2036870 -3.823535 0.0001316 0.0001516 0.0001316 0.0001223 4.589545e-01 0.3078867 6.841452e-01 Ccdc87 up
80 PCDHGA3 PCDHGA3 0.6336887 0.1854916 3.416266 0.0006349 0.0047731 0.0006349 0.0001990 1.884549e+00 1.3101371 2.710805e+00 Pcdhga3 up
101 SEPSECS SEPSECS 1.0745060 0.2684215 4.003055 0.0000625 0.0004790 0.0000625 0.0002610 2.928546e+00 1.7304985 4.956017e+00 Sepsecs down
78 PAX5 PAX5 4.3732708 1.3013911 3.360458 0.0007781 0.0111408 0.0007781 0.0002911 7.930259e+01 6.1878707 1.016327e+03 Pax5 down
54 KCNG1 KCNG1 -0.5347163 0.1540201 -3.471731 0.0005171 0.0001938 0.0005171 0.0004520 5.858355e-01 0.4331851 7.922784e-01 Kcng1 up
85 PHKG1 PHKG1 -0.3998301 0.1165522 -3.430480 0.0006025 0.0009269 0.0006025 0.0004617 6.704339e-01 0.5335149 8.424913e-01 Phkg1 up
50 HHIP HHIP 0.5367070 0.1575686 3.406179 0.0006588 0.0014311 0.0006588 0.0005304 1.710365e+00 1.2559323 2.329225e+00 Hhip up
36 EFCAB6 EFCAB6 -7.0065194 2.0604116 -3.400543 0.0006725 0.0002490 0.0006725 0.0005886 9.060000e-04 0.0000160 5.139640e-02 Efcab6 up
68 METTL11B METTL11B 2.6216611 0.8373169 3.131026 0.0017420 0.0097680 0.0017420 0.0007621 1.375856e+01 2.6659224 7.100655e+01 Mettl11b up
89 PLCXD1 PLCXD1 0.6979770 0.2051305 3.402601 0.0006675 0.0009493 0.0006675 0.0007977 2.009683e+00 1.3443743 3.004242e+00 Plcxd1 up
25 CLEC18A CLEC18A 2.0090652 0.6175386 3.253344 0.0011406 0.0037224 0.0011406 0.0009366 7.456344e+00 2.2226761 2.501357e+01 Clec18a up
82 PCDHGA8 PCDHGA8 4.5064285 1.4663795 3.073167 0.0021180 0.0114419 0.0021180 0.0016940 9.059767e+01 5.1160230 1.604359e+03 Pcdhga8 up
79 PCDH7 PCDH7 -0.7147787 0.2368258 -3.018163 0.0025431 0.0019136 0.0025431 0.0024481 4.893004e-01 0.3076020 7.783268e-01 Pcdh7 up
17 CCNB2 CCNB2 0.3221457 0.1089420 2.957039 0.0031061 0.0046368 0.0031061 0.0027830 1.380086e+00 1.1147424 1.708589e+00 Ccnb2 down
1 ABCA8 ABCA8 0.4256288 0.1413422 3.011336 0.0026010 0.0059862 0.0026010 0.0030725 1.530552e+00 1.1602125 2.019105e+00 Abca8b up
43 GDF10 GDF10 -0.3061819 0.1055962 -2.899555 0.0037369 0.0022250 0.0037369 0.0032660 7.362527e-01 0.5986090 9.055460e-01 Gdf10 up
44 GJA1 GJA1 -0.4050831 0.1380017 -2.935349 0.0033317 0.0035724 0.0033317 0.0034714 6.669214e-01 0.5088706 8.740613e-01 Gja1 up
29 CRTAC1 CRTAC1 -0.5539521 0.1912721 -2.896147 0.0037778 0.0040257 0.0037778 0.0037843 5.746742e-01 0.3950123 8.360510e-01 Crtac1 up
74 NRG3 NRG3 -2.4032161 0.8375289 -2.869413 0.0041123 0.0031459 0.0041123 0.0039243 9.042670e-02 0.0175142 4.668770e-01 Nrg3 up
123 TPSAB1 TPSAB1 -0.7426437 0.2748043 -2.702446 0.0068831 0.0004653 0.0068831 0.0039419 4.758542e-01 0.2776899 8.154320e-01 Tpsb2 down
128 TUB TUB -0.5196510 0.1808249 -2.873780 0.0040559 0.0047320 0.0040559 0.0041056 5.947281e-01 0.4172535 8.476897e-01 Tub up
103 SFTPC SFTPC 0.4223342 0.1487355 2.839498 0.0045185 0.0058762 0.0045185 0.0041667 1.525518e+00 1.1397603 2.041838e+00 Sftpc up
120 TCHH TCHH -0.5988549 0.2142769 -2.794771 0.0051936 0.0025865 0.0051936 0.0050215 5.494404e-01 0.3610171 8.362064e-01 Tchh up
130 VWC2 VWC2 -0.8118496 0.2985573 -2.719242 0.0065432 0.0042834 0.0065432 0.0057806 4.440360e-01 0.2473351 7.971695e-01 Vwc2 up
27 CNGA4 CNGA4 -1.0359853 0.3821171 -2.711172 0.0067046 0.0040296 0.0067046 0.0063590 3.548765e-01 0.1678103 7.504746e-01 Cnga4 up
114 SPHKAP SPHKAP -0.4625777 0.1721975 -2.686321 0.0072244 0.0065275 0.0072244 0.0068047 6.296585e-01 0.4492936 8.824291e-01 Sphkap up
46 GLT8D2 GLT8D2 -1.6440659 0.6170412 -2.664435 0.0077118 0.0045787 0.0077118 0.0071151 1.931929e-01 0.0576454 6.474670e-01 Glt8d2 up
40 FAM186B FAM186B 2.7648858 1.0270985 2.691938 0.0071038 0.0102688 0.0071038 0.0071928 1.587723e+01 2.1208349 1.188618e+02 Fam186b up
5 ADCY2 ADCY2 -0.5091532 0.1915128 -2.658586 0.0078469 0.0086014 0.0078469 0.0075234 6.010043e-01 0.4129159 8.747693e-01 Adcy2 up
87 PLA2G4E PLA2G4E 19.0823473 7.2463960 2.633357 0.0084545 0.0379296 0.0084545 0.0081310 1.938019e+08 131.5875091 2.854313e+14 Pla2g4e up
96 RAB42 RAB42 0.5038644 0.1915025 2.631111 0.0085106 0.0086515 0.0085106 0.0084776 1.655105e+00 1.1371513 2.408978e+00 Rab42 up
73 NR3C2 NR3C2 -1.1889369 0.4523989 -2.628072 0.0085870 0.0066070 0.0085870 0.0085969 3.045449e-01 0.1254783 7.391523e-01 Nr3c2 up
60 LRRC18 LRRC18 0.8248612 0.3172093 2.600369 0.0093124 0.0202333 0.0093124 0.0094480 2.281564e+00 1.2252469 4.248560e+00 Lrrc18 up
66 MAP6D1 MAP6D1 0.3520670 0.1365555 2.578198 0.0099317 0.0104100 0.0099317 0.0094586 1.422004e+00 1.0880893 1.858390e+00 Map6d1 up
69 MGAT4C MGAT4C -1.3821722 0.5241332 -2.637063 0.0083627 0.0040005 0.0083627 0.0095399 2.510327e-01 0.0898643 7.012506e-01 Mgat4c up
106 SLAIN2 SLAIN2 0.8455718 0.3292619 2.568083 0.0102263 0.0111327 0.0102263 0.0096223 2.329309e+00 1.2216841 4.441149e+00 Slain2 down
113 SPAG17 SPAG17 10.0872014 4.2371258 2.380671 0.0172812 0.0574988 0.0172812 0.0110288 2.403344e+04 5.9452191 9.715474e+07 Spag17 up
37 EFEMP1 EFEMP1 -0.2914440 0.1149583 -2.535214 0.0112379 0.0122232 0.0112379 0.0111204 7.471839e-01 0.5964510 9.360093e-01 Efemp1 up
12 CACNA2D2 CACNA2D2 -0.8043295 0.3205444 -2.509261 0.0120984 0.0098839 0.0120984 0.0118147 4.473878e-01 0.2386911 8.385559e-01 Cacna2d2 up
55 KLF14 KLF14 1.6071670 0.6370812 2.522703 0.0116457 0.0346226 0.0116457 0.0119965 4.988658e+00 1.4311964 1.738875e+01 Klf14 up
127 TTLL7 TTLL7 0.4510948 0.1808449 2.494374 0.0126179 0.0140847 0.0126179 0.0121624 1.570030e+00 1.1014697 2.237914e+00 Ttll7 up
28 CPA3 CPA3 -2.6676371 1.2839007 -2.077760 0.0377315 0.0010779 0.0377315 0.0122039 6.941610e-02 0.0056053 8.596431e-01 Cpa3 down
94 PRIMA1 PRIMA1 0.6222890 0.2488279 2.500881 0.0123885 0.0134312 0.0123885 0.0122378 1.863188e+00 1.1440737 3.034306e+00 Prima1 up
110 SLC7A11 SLC7A11 -0.5173928 0.2068672 -2.501087 0.0123813 0.0111473 0.0123813 0.0128561 5.960726e-01 0.3973869 8.940974e-01 Slc7a11 up
83 PDGFRA PDGFRA 0.3197732 0.1282574 2.493214 0.0126593 0.0114151 0.0126593 0.0129613 1.376815e+00 1.0707863 1.770307e+00 Pdgfra down
65 MAGEE2 MAGEE2 0.2072085 0.0847911 2.443752 0.0145354 0.0121291 0.0145354 0.0129998 1.230239e+00 1.0418739 1.452659e+00 Magee2 up
26 CLMN CLMN 0.5914685 0.2374123 2.491314 0.0127272 0.0186262 0.0127272 0.0131366 1.806639e+00 1.1344511 2.877115e+00 Clmn up
93 PPP2R2B PPP2R2B -0.7571162 0.3070699 -2.465615 0.0136778 0.0122080 0.0136778 0.0135049 4.690170e-01 0.2569273 8.561837e-01 Ppp2r2b up
70 MSR1 MSR1 0.6293928 0.2584362 2.435390 0.0148758 0.0257520 0.0148758 0.0144026 1.876471e+00 1.1307343 3.114032e+00 Msr1 down
16 CCL27 CCL27 -10.1807420 4.9394362 -2.061114 0.0392921 0.0011244 0.0392921 0.0147958 3.790000e-05 0.0000000 6.067582e-01 Ccl27a up
111 SLITRK5 SLITRK5 -0.4852339 0.1987193 -2.441806 0.0146140 0.0166802 0.0146140 0.0148097 6.155532e-01 0.4169802 9.086900e-01 Slitrk5 up
121 TFCP2L1 TFCP2L1 0.4640884 0.1932673 2.401277 0.0163379 0.0254705 0.0163379 0.0148488 1.590564e+00 1.0890344 2.323060e+00 Tfcp2l1 up
100 SCUBE3 SCUBE3 0.5114631 0.2125001 2.406884 0.0160893 0.0256815 0.0160893 0.0148709 1.667729e+00 1.0996264 2.529333e+00 Scube3 up
134 ZCCHC3 ZCCHC3 0.8449587 0.3501292 2.413277 0.0158098 0.0144719 0.0158098 0.0157013 2.327882e+00 1.1720075 4.623719e+00 Zcchc3 up
6 AHCYL2 AHCYL2 -0.4618186 0.1916865 -2.409239 0.0159858 0.0144949 0.0159858 0.0157534 6.301366e-01 0.4327837 9.174842e-01 Ahcyl2 up
84 PELI3 PELI3 -0.5361502 0.2219673 -2.415447 0.0157159 0.0125532 0.0157159 0.0158807 5.849960e-01 0.3786292 9.038405e-01 Peli3 up
117 SYT12 SYT12 -0.3974626 0.1658915 -2.395919 0.0165787 0.0103877 0.0165787 0.0161174 6.720231e-01 0.4854864 9.302320e-01 Syt12 up
61 LRRC6 LRRC6 -1.2100537 0.5083194 -2.380499 0.0172892 0.0148202 0.0172892 0.0162693 2.981813e-01 0.1101027 8.075373e-01 Lrrc6 up
77 OSR1 OSR1 0.2144682 0.0905432 2.368683 0.0178516 0.0251440 0.0178516 0.0166777 1.239203e+00 1.0377000 1.479834e+00 Osr1 up
90 PLK5 PLK5 -0.5414021 0.2291631 -2.362518 0.0181512 0.0166165 0.0181512 0.0175387 5.819318e-01 0.3713711 9.118766e-01 Plk5 up
59 LIX1 LIX1 -0.2840070 0.1205932 -2.355083 0.0185186 0.0237242 0.0185186 0.0177018 7.527614e-01 0.5943034 9.534687e-01 Lix1 up
45 GLRA3 GLRA3 -0.6180356 0.2634646 -2.345801 0.0189862 0.0133041 0.0189862 0.0185040 5.390022e-01 0.3216097 9.033416e-01 Glra3 up
71 NIPAL3 NIPAL3 0.3068599 0.1315510 2.332631 0.0196675 0.0202769 0.0196675 0.0189767 1.359150e+00 1.0502462 1.758911e+00 Nipal3 up
75 NSUN7 NSUN7 2.8988354 1.2476243 2.323484 0.0201532 0.0274793 0.0201532 0.0194083 1.815299e+01 1.5738687 2.093765e+02 Nsun7 up
3 ABLIM3 ABLIM3 -0.4204272 0.1804536 -2.329836 0.0198148 0.0196918 0.0198148 0.0196757 6.567662e-01 0.4611141 9.354340e-01 Ablim3 up
98 RNF32 RNF32 -0.7549155 0.3244026 -2.327095 0.0199602 0.0195812 0.0199602 0.0197767 4.700503e-01 0.2488928 8.877207e-01 Rnf32 up
30 CRYBB1 CRYBB1 -0.6109657 0.2598025 -2.351655 0.0186901 0.0162412 0.0186901 0.0199216 5.428264e-01 0.3262246 9.032443e-01 Crybb1 up
122 TNNI1 TNNI1 2.8923203 1.3335905 2.168822 0.0300962 0.0799377 0.0300962 0.0199732 1.803511e+01 1.3211876 2.461915e+02 Tnni1 up
91 POPDC3 POPDC3 0.3123546 0.1361879 2.293555 0.0218161 0.0284385 0.0218161 0.0201892 1.366639e+00 1.0464789 1.784749e+00 Popdc3 up
14 CAMSAP3 CAMSAP3 -0.2662145 0.1163447 -2.288152 0.0221286 0.0232764 0.0221286 0.0215514 7.662747e-01 0.6100307 9.625368e-01 Camsap3 up
42 FZD2 FZD2 0.3875964 0.1688566 2.295418 0.0217092 0.0214499 0.0217092 0.0216465 1.473435e+00 1.0582785 2.051455e+00 Fzd2 up
135 ZCCHC4 ZCCHC4 0.7571164 0.3109674 2.434713 0.0149036 0.0324878 0.0149036 0.0221649 2.132119e+00 1.1590857 3.921998e+00 Zcchc4 down
124 TPSB2 TPSB2 -0.4678065 0.2090684 -2.237576 0.0252487 0.0102559 0.0252487 0.0225107 6.263747e-01 0.4157908 9.436123e-01 Tpsb2 down
109 SLC4A4 SLC4A4 -0.4141597 0.1824616 -2.269846 0.0232169 0.0246088 0.0232169 0.0226269 6.608954e-01 0.4621906 9.450271e-01 Slc4a4 up
52 HTR2C HTR2C -3.1565775 1.3995778 -2.255378 0.0241096 0.0133067 0.0241096 0.0232918 4.257120e-02 0.0027403 6.613610e-01 Htr2c up
108 SLC35F4 SLC35F4 6.9660928 3.4145385 2.040127 0.0413377 0.1207829 0.0413377 0.0234941 1.060073e+03 1.3148471 8.546653e+05 Slc35f4 up
39 FAM111A FAM111A 0.4931808 0.2189509 2.252472 0.0242925 0.0261799 0.0242925 0.0238429 1.637517e+00 1.0661403 2.515110e+00 Fam111a down
118 SYT17 SYT17 -0.6691720 0.2974328 -2.249826 0.0244600 0.0230309 0.0244600 0.0240354 5.121324e-01 0.2858953 9.173975e-01 Syt17 up
95 PROK2 PROK2 1.8148931 0.8212733 2.209853 0.0271154 0.0412250 0.0271154 0.0258169 6.140420e+00 1.2278037 3.070911e+01 Prok2 up
136 ZNF519 ZNF519 0.7099944 0.3196717 2.221011 0.0263502 0.0282681 0.0263502 0.0258965 2.033980e+00 1.0870303 3.805850e+00 Zfp941 up
92 PPIL6 PPIL6 -0.8190445 0.3663250 -2.235841 0.0253622 0.0228182 0.0253622 0.0262949 4.408527e-01 0.2150191 9.038782e-01 Ppil6 up
67 MEIG1 MEIG1 -1.4153405 0.6416480 -2.205790 0.0273987 0.0165410 0.0273987 0.0263250 2.428429e-01 0.0690484 8.540773e-01 Meig1 up
41 FRY FRY -0.6736747 0.3074954 -2.190845 0.0284630 0.0283663 0.0284630 0.0281425 5.098316e-01 0.2790527 9.314667e-01 Fry up
24 CHST15 CHST15 -0.4167445 0.1902333 -2.190702 0.0284734 0.0278526 0.0284734 0.0281733 6.591893e-01 0.4540287 9.570553e-01 Chst15 up
19 CDH7 CDH7 -0.6616486 0.3054743 -2.165971 0.0303134 0.0216067 0.0303134 0.0286263 5.160000e-01 0.2835499 9.390093e-01 Cdh7 up
57 KNDC1 KNDC1 -0.2969632 0.1366881 -2.172560 0.0298134 0.0279141 0.0298134 0.0293196 7.430714e-01 0.5684358 9.713588e-01 Kndc1 up
125 TTC34 TTC34 -3.7733836 1.7457180 -2.161508 0.0306561 0.0235946 0.0306561 0.0297951 2.297420e-02 0.0007504 7.033933e-01 Ttc34 up
49 HHATL HHATL 0.2470745 0.1144943 2.157963 0.0309307 0.0303280 0.0309307 0.0308650 1.280274e+00 1.0229287 1.602363e+00 Hhatl up
53 KCNB1 KCNB1 -0.4829054 0.2251743 -2.144585 0.0319861 0.0281475 0.0319861 0.0316609 6.169882e-01 0.3968333 9.592804e-01 Kcnb1 up
51 HS6ST2 HS6ST2 0.8537621 0.4008883 2.129676 0.0331984 0.0357143 0.0331984 0.0317125 2.348466e+00 1.0704032 5.152535e+00 Hs6st2 up
126 TTLL11 TTLL11 1.3664702 0.6377193 2.142745 0.0321335 0.0412975 0.0321335 0.0321406 3.921484e+00 1.1236286 1.368605e+01 Ttll11 up
72 NLRP6 NLRP6 0.5442128 0.2548265 2.135621 0.0327103 0.0448962 0.0327103 0.0322133 1.723251e+00 1.0457789 2.839601e+00 Nlrp6 up
64 LUZP2 LUZP2 -0.3671389 0.1727341 -2.125457 0.0335485 0.0367364 0.0335485 0.0323780 6.927134e-01 0.4937670 9.718185e-01 Luzp2 up
10 BRINP1 BRINP1 -0.3392242 0.1600891 -2.118972 0.0340928 0.0305033 0.0340928 0.0324119 7.123227e-01 0.5204856 9.748658e-01 Brinp1 up
56 KLHDC9 KLHDC9 -0.2353128 0.1106619 -2.126413 0.0334689 0.0371299 0.0334689 0.0330566 7.903236e-01 0.6362230 9.817491e-01 Klhdc9 up
88 PLCB1 PLCB1 -0.6420079 0.3024846 -2.122448 0.0338001 0.0324093 0.0338001 0.0333069 5.262348e-01 0.2908735 9.520392e-01 Plcb1 up
105 SIDT1 SIDT1 -0.4174642 0.1983770 -2.104398 0.0353437 0.0278401 0.0353437 0.0339631 6.587150e-01 0.4465178 9.717541e-01 Sidt1 up
107 SLC1A2 SLC1A2 -0.2124443 0.1003561 -2.116904 0.0342680 0.0375824 0.0342680 0.0340428 8.086053e-01 0.6642221 9.843735e-01 Slc1a2 up
38 EMID1 EMID1 -0.4502308 0.2133506 -2.110287 0.0348337 0.0338802 0.0348337 0.0343860 6.374810e-01 0.4196265 9.684374e-01 Emid1 up
13 CACNA2D4 CACNA2D4 1.0245697 0.4891258 2.094696 0.0361980 0.0427101 0.0361980 0.0350024 2.785896e+00 1.0681207 7.266237e+00 Cacna2d4 up
76 NXPH3 NXPH3 -0.3774392 0.1806948 -2.088822 0.0367238 0.0409742 0.0367238 0.0363733 6.856149e-01 0.4811412 9.769850e-01 Nxph3 up
129 UNC13B UNC13B -0.7827685 0.3736143 -2.095125 0.0361599 0.0336327 0.0361599 0.0369294 4.571387e-01 0.2197996 9.507559e-01 Unc13b up
132 WNT9A WNT9A 0.6958626 0.3367280 2.066542 0.0387773 0.0463104 0.0387773 0.0378423 2.005438e+00 1.0365397 3.880008e+00 Wnt9a up
112 SMIM1 SMIM1 0.5206950 0.2527491 2.060126 0.0393865 0.0428917 0.0393865 0.0385225 1.683197e+00 1.0256390 2.762329e+00 Smim1 up
9 BAIAP3 BAIAP3 -0.2794113 0.1351514 -2.067396 0.0386969 0.0418946 0.0386969 0.0390339 7.562288e-01 0.5802460 9.855853e-01 Baiap3 up
33 DMKN DMKN -0.3291229 0.1606125 -2.049173 0.0404452 0.0368210 0.0404452 0.0393216 7.195546e-01 0.5252307 9.857741e-01 Dmkn up
115 SPRY3 SPRY3 0.4960903 0.2418322 2.051382 0.0402298 0.0386226 0.0402298 0.0404007 1.642288e+00 1.0223540 2.638136e+00 Spry3 up
2 ABHD3 ABHD3 0.5955091 0.2929307 2.032935 0.0420591 0.0407117 0.0420591 0.0409840 1.813954e+00 1.0216055 3.220842e+00 Abhd3 up
18 CD5L CD5L 0.7754014 0.3848963 2.014572 0.0439495 0.1129359 0.0439495 0.0414056 2.171464e+00 1.0212410 4.617181e+00 Cd5l down
58 LGI3 LGI3 0.1822722 0.0897599 2.030665 0.0422890 0.0443037 0.0422890 0.0414997 1.199941e+00 1.0063663 1.430749e+00 Lgi3 up
99 RSPO3 RSPO3 -0.6746499 0.3363098 -2.006037 0.0448523 0.0301619 0.0448523 0.0427121 5.093347e-01 0.2634728 9.846247e-01 Rspo3 up
32 DCHS2 DCHS2 -1.0486217 0.5210343 -2.012577 0.0441591 0.0349509 0.0441591 0.0427312 3.504204e-01 0.1262072 9.729591e-01 Dchs2 up
35 DNAH12 DNAH12 3.9025793 1.9420087 2.009558 0.0444780 0.0681526 0.0444780 0.0436603 4.953004e+01 1.1011029 2.227971e+03 Dnah12 up
31 CYB561 CYB561 -0.3508557 0.1754585 -1.999651 0.0455380 0.0350770 0.0455380 0.0445372 7.040854e-01 0.4992003 9.930608e-01 Cyb561 up
48 GPR176 GPR176 0.3455603 0.1729604 1.997916 0.0457257 0.0478815 0.0457257 0.0446132 1.412781e+00 1.0065858 1.982892e+00 Gpr176 up
34 DMRTC1 DMRTC1 98.5643120 49.8616264 1.976757 0.0480691 0.0630351 0.0480691 0.0448591 6.396418e+42 2.3101676 1.771047e+85 Dmrtc1a up
116 SPTBN5 SPTBN5 0.6025659 0.3021065 1.994548 0.0460922 0.0585582 0.0460922 0.0449381 1.826800e+00 1.0105029 3.302513e+00 Sptbn5 up
8 ARPP21 ARPP21 -0.3743726 0.1867061 -2.005144 0.0449477 0.0462126 0.0449477 0.0451881 6.877206e-01 0.4769661 9.916001e-01 Arpp21 up
7 ALDOC ALDOC -0.2765491 0.1381129 -2.002341 0.0452480 0.0542366 0.0452480 0.0455496 7.583964e-01 0.5785413 9.941643e-01 Aldoc up
23 CHST1 CHST1 -0.2144981 0.1081277 -1.983748 0.0472839 0.0521806 0.0472839 0.0467366 8.069463e-01 0.6528391 9.974316e-01 Chst1 up
131 WNT4 WNT4 -0.7042827 0.3598625 -1.957089 0.0503371 0.0247391 0.0503371 0.0469690 4.944631e-01 0.2442409 1.001035e+00 Wnt4 up
20 CDK6 CDK6 0.3824756 0.1938366 1.973185 0.0484744 0.0528413 0.0484744 0.0485995 1.465909e+00 1.0025661 2.143389e+00 Cdk6 down
97 RASGRF1 RASGRF1 -0.2693178 0.1370775 -1.964712 0.0494476 0.0439386 0.0494476 0.0487218 7.639004e-01 0.5839238 9.993493e-01 Rasgrf1 up
4 ADAMTS3 ADAMTS3 1.9769091 0.9586936 2.062086 0.0391995 0.0865033 0.0391995 0.0488657 7.220391e+00 1.1028571 4.727180e+01 Adamts3 up
119 SYT3 SYT3 -0.3410561 0.1739619 -1.960522 0.0499348 0.0391895 0.0499348 0.0489593 7.110190e-01 0.5055971 9.999029e-01 Syt3 up
81 PCDHGA4 PCDHGA4 1.0331251 0.5206786 1.984190 0.0472347 0.0638059 0.0472347 0.0497464 2.809833e+00 1.0126938 7.796199e+00 Pcdhga4 up
63 LSAMP LSAMP -0.6089189 0.3110885 -1.957382 0.0503026 0.0520013 0.0503026 0.0499826 5.439386e-01 0.2956316 1.000804e+00 Lsamp up

IDH_CODEL_NOCODEL

Gene-sets considered

UP and DOWN

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Table genes

Variable Term Beta StandardError Z P LRT Wald LogRank HR HRlower HRupper mm status
47 GPR139 GPR139 2.9954716 0.5459944 5.486268 0.0000000 0.0000008 0.0000000 0.0000000 1.999479e+01 6.8574946 5.829993e+01 Gpr139 up
11 BVES BVES 0.7842063 0.1424517 5.505070 0.0000000 0.0000025 0.0000000 0.0000001 2.190667e+00 1.6569958 2.896220e+00 Bves up
22 CHIC2 CHIC2 1.1744777 0.2267115 5.180495 0.0000002 0.0000079 0.0000002 0.0000002 3.236452e+00 2.0753531 5.047152e+00 Chic2 down
62 LRRK2 LRRK2 0.6724442 0.1341983 5.010825 0.0000005 0.0000059 0.0000005 0.0000002 1.959020e+00 1.5059447 2.548406e+00 Lrrk2 up
21 CEP135 CEP135 1.1901584 0.2479228 4.800520 0.0000016 0.0000491 0.0000016 0.0000014 3.287602e+00 2.0223064 5.344554e+00 Cep135 down
133 ZBTB8B ZBTB8B 1.1045218 0.2349319 4.701455 0.0000026 0.0000192 0.0000026 0.0000022 3.017781e+00 1.9042034 4.782579e+00 Zbtb8b up
86 PI4K2B PI4K2B 1.0371524 0.2498474 4.151143 0.0000331 0.0015532 0.0000331 0.0000217 2.821172e+00 1.7288568 4.603626e+00 Pi4k2b down
102 SERINC2 SERINC2 0.6263722 0.1610620 3.889012 0.0001007 0.0002453 0.0001007 0.0000827 1.870811e+00 1.3643749 2.565230e+00 Serinc2 up
104 SH3GL2 SH3GL2 -0.7907620 0.2005988 -3.942008 0.0000808 0.0000695 0.0000808 0.0001115 4.534991e-01 0.3060740 6.719337e-01 Sh3gl2 up
15 CCDC87 CCDC87 -0.7788043 0.2036870 -3.823535 0.0001316 0.0001516 0.0001316 0.0001223 4.589545e-01 0.3078867 6.841452e-01 Ccdc87 up
80 PCDHGA3 PCDHGA3 0.6336887 0.1854916 3.416266 0.0006349 0.0047731 0.0006349 0.0001990 1.884549e+00 1.3101371 2.710805e+00 Pcdhga3 up
101 SEPSECS SEPSECS 1.0745060 0.2684215 4.003055 0.0000625 0.0004790 0.0000625 0.0002610 2.928546e+00 1.7304985 4.956017e+00 Sepsecs down
78 PAX5 PAX5 4.3732708 1.3013911 3.360458 0.0007781 0.0111408 0.0007781 0.0002911 7.930259e+01 6.1878707 1.016327e+03 Pax5 down
54 KCNG1 KCNG1 -0.5347163 0.1540201 -3.471731 0.0005171 0.0001938 0.0005171 0.0004520 5.858355e-01 0.4331851 7.922784e-01 Kcng1 up
85 PHKG1 PHKG1 -0.3998301 0.1165522 -3.430480 0.0006025 0.0009269 0.0006025 0.0004617 6.704339e-01 0.5335149 8.424913e-01 Phkg1 up
50 HHIP HHIP 0.5367070 0.1575686 3.406179 0.0006588 0.0014311 0.0006588 0.0005304 1.710365e+00 1.2559323 2.329225e+00 Hhip up
36 EFCAB6 EFCAB6 -7.0065194 2.0604116 -3.400543 0.0006725 0.0002490 0.0006725 0.0005886 9.060000e-04 0.0000160 5.139640e-02 Efcab6 up
68 METTL11B METTL11B 2.6216611 0.8373169 3.131026 0.0017420 0.0097680 0.0017420 0.0007621 1.375856e+01 2.6659224 7.100655e+01 Mettl11b up
89 PLCXD1 PLCXD1 0.6979770 0.2051305 3.402601 0.0006675 0.0009493 0.0006675 0.0007977 2.009683e+00 1.3443743 3.004242e+00 Plcxd1 up
25 CLEC18A CLEC18A 2.0090652 0.6175386 3.253344 0.0011406 0.0037224 0.0011406 0.0009366 7.456344e+00 2.2226761 2.501357e+01 Clec18a up
82 PCDHGA8 PCDHGA8 4.5064285 1.4663795 3.073167 0.0021180 0.0114419 0.0021180 0.0016940 9.059767e+01 5.1160230 1.604359e+03 Pcdhga8 up
79 PCDH7 PCDH7 -0.7147787 0.2368258 -3.018163 0.0025431 0.0019136 0.0025431 0.0024481 4.893004e-01 0.3076020 7.783268e-01 Pcdh7 up
17 CCNB2 CCNB2 0.3221457 0.1089420 2.957039 0.0031061 0.0046368 0.0031061 0.0027830 1.380086e+00 1.1147424 1.708589e+00 Ccnb2 down
1 ABCA8 ABCA8 0.4256288 0.1413422 3.011336 0.0026010 0.0059862 0.0026010 0.0030725 1.530552e+00 1.1602125 2.019105e+00 Abca8b up
43 GDF10 GDF10 -0.3061819 0.1055962 -2.899555 0.0037369 0.0022250 0.0037369 0.0032660 7.362527e-01 0.5986090 9.055460e-01 Gdf10 up
44 GJA1 GJA1 -0.4050831 0.1380017 -2.935349 0.0033317 0.0035724 0.0033317 0.0034714 6.669214e-01 0.5088706 8.740613e-01 Gja1 up
29 CRTAC1 CRTAC1 -0.5539521 0.1912721 -2.896147 0.0037778 0.0040257 0.0037778 0.0037843 5.746742e-01 0.3950123 8.360510e-01 Crtac1 up
74 NRG3 NRG3 -2.4032161 0.8375289 -2.869413 0.0041123 0.0031459 0.0041123 0.0039243 9.042670e-02 0.0175142 4.668770e-01 Nrg3 up
123 TPSAB1 TPSAB1 -0.7426437 0.2748043 -2.702446 0.0068831 0.0004653 0.0068831 0.0039419 4.758542e-01 0.2776899 8.154320e-01 Tpsb2 down
128 TUB TUB -0.5196510 0.1808249 -2.873780 0.0040559 0.0047320 0.0040559 0.0041056 5.947281e-01 0.4172535 8.476897e-01 Tub up
103 SFTPC SFTPC 0.4223342 0.1487355 2.839498 0.0045185 0.0058762 0.0045185 0.0041667 1.525518e+00 1.1397603 2.041838e+00 Sftpc up
120 TCHH TCHH -0.5988549 0.2142769 -2.794771 0.0051936 0.0025865 0.0051936 0.0050215 5.494404e-01 0.3610171 8.362064e-01 Tchh up
130 VWC2 VWC2 -0.8118496 0.2985573 -2.719242 0.0065432 0.0042834 0.0065432 0.0057806 4.440360e-01 0.2473351 7.971695e-01 Vwc2 up
27 CNGA4 CNGA4 -1.0359853 0.3821171 -2.711172 0.0067046 0.0040296 0.0067046 0.0063590 3.548765e-01 0.1678103 7.504746e-01 Cnga4 up
114 SPHKAP SPHKAP -0.4625777 0.1721975 -2.686321 0.0072244 0.0065275 0.0072244 0.0068047 6.296585e-01 0.4492936 8.824291e-01 Sphkap up
46 GLT8D2 GLT8D2 -1.6440659 0.6170412 -2.664435 0.0077118 0.0045787 0.0077118 0.0071151 1.931929e-01 0.0576454 6.474670e-01 Glt8d2 up
40 FAM186B FAM186B 2.7648858 1.0270985 2.691938 0.0071038 0.0102688 0.0071038 0.0071928 1.587723e+01 2.1208349 1.188618e+02 Fam186b up
5 ADCY2 ADCY2 -0.5091532 0.1915128 -2.658586 0.0078469 0.0086014 0.0078469 0.0075234 6.010043e-01 0.4129159 8.747693e-01 Adcy2 up
87 PLA2G4E PLA2G4E 19.0823473 7.2463960 2.633357 0.0084545 0.0379296 0.0084545 0.0081310 1.938019e+08 131.5875091 2.854313e+14 Pla2g4e up
96 RAB42 RAB42 0.5038644 0.1915025 2.631111 0.0085106 0.0086515 0.0085106 0.0084776 1.655105e+00 1.1371513 2.408978e+00 Rab42 up
73 NR3C2 NR3C2 -1.1889369 0.4523989 -2.628072 0.0085870 0.0066070 0.0085870 0.0085969 3.045449e-01 0.1254783 7.391523e-01 Nr3c2 up
60 LRRC18 LRRC18 0.8248612 0.3172093 2.600369 0.0093124 0.0202333 0.0093124 0.0094480 2.281564e+00 1.2252469 4.248560e+00 Lrrc18 up
66 MAP6D1 MAP6D1 0.3520670 0.1365555 2.578198 0.0099317 0.0104100 0.0099317 0.0094586 1.422004e+00 1.0880893 1.858390e+00 Map6d1 up
69 MGAT4C MGAT4C -1.3821722 0.5241332 -2.637063 0.0083627 0.0040005 0.0083627 0.0095399 2.510327e-01 0.0898643 7.012506e-01 Mgat4c up
106 SLAIN2 SLAIN2 0.8455718 0.3292619 2.568083 0.0102263 0.0111327 0.0102263 0.0096223 2.329309e+00 1.2216841 4.441149e+00 Slain2 down
113 SPAG17 SPAG17 10.0872014 4.2371258 2.380671 0.0172812 0.0574988 0.0172812 0.0110288 2.403344e+04 5.9452191 9.715474e+07 Spag17 up
37 EFEMP1 EFEMP1 -0.2914440 0.1149583 -2.535214 0.0112379 0.0122232 0.0112379 0.0111204 7.471839e-01 0.5964510 9.360093e-01 Efemp1 up
12 CACNA2D2 CACNA2D2 -0.8043295 0.3205444 -2.509261 0.0120984 0.0098839 0.0120984 0.0118147 4.473878e-01 0.2386911 8.385559e-01 Cacna2d2 up
55 KLF14 KLF14 1.6071670 0.6370812 2.522703 0.0116457 0.0346226 0.0116457 0.0119965 4.988658e+00 1.4311964 1.738875e+01 Klf14 up
127 TTLL7 TTLL7 0.4510948 0.1808449 2.494374 0.0126179 0.0140847 0.0126179 0.0121624 1.570030e+00 1.1014697 2.237914e+00 Ttll7 up
28 CPA3 CPA3 -2.6676371 1.2839007 -2.077760 0.0377315 0.0010779 0.0377315 0.0122039 6.941610e-02 0.0056053 8.596431e-01 Cpa3 down
94 PRIMA1 PRIMA1 0.6222890 0.2488279 2.500881 0.0123885 0.0134312 0.0123885 0.0122378 1.863188e+00 1.1440737 3.034306e+00 Prima1 up
110 SLC7A11 SLC7A11 -0.5173928 0.2068672 -2.501087 0.0123813 0.0111473 0.0123813 0.0128561 5.960726e-01 0.3973869 8.940974e-01 Slc7a11 up
83 PDGFRA PDGFRA 0.3197732 0.1282574 2.493214 0.0126593 0.0114151 0.0126593 0.0129613 1.376815e+00 1.0707863 1.770307e+00 Pdgfra down
65 MAGEE2 MAGEE2 0.2072085 0.0847911 2.443752 0.0145354 0.0121291 0.0145354 0.0129998 1.230239e+00 1.0418739 1.452659e+00 Magee2 up
26 CLMN CLMN 0.5914685 0.2374123 2.491314 0.0127272 0.0186262 0.0127272 0.0131366 1.806639e+00 1.1344511 2.877115e+00 Clmn up
93 PPP2R2B PPP2R2B -0.7571162 0.3070699 -2.465615 0.0136778 0.0122080 0.0136778 0.0135049 4.690170e-01 0.2569273 8.561837e-01 Ppp2r2b up
70 MSR1 MSR1 0.6293928 0.2584362 2.435390 0.0148758 0.0257520 0.0148758 0.0144026 1.876471e+00 1.1307343 3.114032e+00 Msr1 down
16 CCL27 CCL27 -10.1807420 4.9394362 -2.061114 0.0392921 0.0011244 0.0392921 0.0147958 3.790000e-05 0.0000000 6.067582e-01 Ccl27a up
111 SLITRK5 SLITRK5 -0.4852339 0.1987193 -2.441806 0.0146140 0.0166802 0.0146140 0.0148097 6.155532e-01 0.4169802 9.086900e-01 Slitrk5 up
121 TFCP2L1 TFCP2L1 0.4640884 0.1932673 2.401277 0.0163379 0.0254705 0.0163379 0.0148488 1.590564e+00 1.0890344 2.323060e+00 Tfcp2l1 up
100 SCUBE3 SCUBE3 0.5114631 0.2125001 2.406884 0.0160893 0.0256815 0.0160893 0.0148709 1.667729e+00 1.0996264 2.529333e+00 Scube3 up
134 ZCCHC3 ZCCHC3 0.8449587 0.3501292 2.413277 0.0158098 0.0144719 0.0158098 0.0157013 2.327882e+00 1.1720075 4.623719e+00 Zcchc3 up
6 AHCYL2 AHCYL2 -0.4618186 0.1916865 -2.409239 0.0159858 0.0144949 0.0159858 0.0157534 6.301366e-01 0.4327837 9.174842e-01 Ahcyl2 up
84 PELI3 PELI3 -0.5361502 0.2219673 -2.415447 0.0157159 0.0125532 0.0157159 0.0158807 5.849960e-01 0.3786292 9.038405e-01 Peli3 up
117 SYT12 SYT12 -0.3974626 0.1658915 -2.395919 0.0165787 0.0103877 0.0165787 0.0161174 6.720231e-01 0.4854864 9.302320e-01 Syt12 up
61 LRRC6 LRRC6 -1.2100537 0.5083194 -2.380499 0.0172892 0.0148202 0.0172892 0.0162693 2.981813e-01 0.1101027 8.075373e-01 Lrrc6 up
77 OSR1 OSR1 0.2144682 0.0905432 2.368683 0.0178516 0.0251440 0.0178516 0.0166777 1.239203e+00 1.0377000 1.479834e+00 Osr1 up
90 PLK5 PLK5 -0.5414021 0.2291631 -2.362518 0.0181512 0.0166165 0.0181512 0.0175387 5.819318e-01 0.3713711 9.118766e-01 Plk5 up
59 LIX1 LIX1 -0.2840070 0.1205932 -2.355083 0.0185186 0.0237242 0.0185186 0.0177018 7.527614e-01 0.5943034 9.534687e-01 Lix1 up
45 GLRA3 GLRA3 -0.6180356 0.2634646 -2.345801 0.0189862 0.0133041 0.0189862 0.0185040 5.390022e-01 0.3216097 9.033416e-01 Glra3 up
71 NIPAL3 NIPAL3 0.3068599 0.1315510 2.332631 0.0196675 0.0202769 0.0196675 0.0189767 1.359150e+00 1.0502462 1.758911e+00 Nipal3 up
75 NSUN7 NSUN7 2.8988354 1.2476243 2.323484 0.0201532 0.0274793 0.0201532 0.0194083 1.815299e+01 1.5738687 2.093765e+02 Nsun7 up
3 ABLIM3 ABLIM3 -0.4204272 0.1804536 -2.329836 0.0198148 0.0196918 0.0198148 0.0196757 6.567662e-01 0.4611141 9.354340e-01 Ablim3 up
98 RNF32 RNF32 -0.7549155 0.3244026 -2.327095 0.0199602 0.0195812 0.0199602 0.0197767 4.700503e-01 0.2488928 8.877207e-01 Rnf32 up
30 CRYBB1 CRYBB1 -0.6109657 0.2598025 -2.351655 0.0186901 0.0162412 0.0186901 0.0199216 5.428264e-01 0.3262246 9.032443e-01 Crybb1 up
122 TNNI1 TNNI1 2.8923203 1.3335905 2.168822 0.0300962 0.0799377 0.0300962 0.0199732 1.803511e+01 1.3211876 2.461915e+02 Tnni1 up
91 POPDC3 POPDC3 0.3123546 0.1361879 2.293555 0.0218161 0.0284385 0.0218161 0.0201892 1.366639e+00 1.0464789 1.784749e+00 Popdc3 up
14 CAMSAP3 CAMSAP3 -0.2662145 0.1163447 -2.288152 0.0221286 0.0232764 0.0221286 0.0215514 7.662747e-01 0.6100307 9.625368e-01 Camsap3 up
42 FZD2 FZD2 0.3875964 0.1688566 2.295418 0.0217092 0.0214499 0.0217092 0.0216465 1.473435e+00 1.0582785 2.051455e+00 Fzd2 up
135 ZCCHC4 ZCCHC4 0.7571164 0.3109674 2.434713 0.0149036 0.0324878 0.0149036 0.0221649 2.132119e+00 1.1590857 3.921998e+00 Zcchc4 down
124 TPSB2 TPSB2 -0.4678065 0.2090684 -2.237576 0.0252487 0.0102559 0.0252487 0.0225107 6.263747e-01 0.4157908 9.436123e-01 Tpsb2 down
109 SLC4A4 SLC4A4 -0.4141597 0.1824616 -2.269846 0.0232169 0.0246088 0.0232169 0.0226269 6.608954e-01 0.4621906 9.450271e-01 Slc4a4 up
52 HTR2C HTR2C -3.1565775 1.3995778 -2.255378 0.0241096 0.0133067 0.0241096 0.0232918 4.257120e-02 0.0027403 6.613610e-01 Htr2c up
108 SLC35F4 SLC35F4 6.9660928 3.4145385 2.040127 0.0413377 0.1207829 0.0413377 0.0234941 1.060073e+03 1.3148471 8.546653e+05 Slc35f4 up
39 FAM111A FAM111A 0.4931808 0.2189509 2.252472 0.0242925 0.0261799 0.0242925 0.0238429 1.637517e+00 1.0661403 2.515110e+00 Fam111a down
118 SYT17 SYT17 -0.6691720 0.2974328 -2.249826 0.0244600 0.0230309 0.0244600 0.0240354 5.121324e-01 0.2858953 9.173975e-01 Syt17 up
95 PROK2 PROK2 1.8148931 0.8212733 2.209853 0.0271154 0.0412250 0.0271154 0.0258169 6.140420e+00 1.2278037 3.070911e+01 Prok2 up
136 ZNF519 ZNF519 0.7099944 0.3196717 2.221011 0.0263502 0.0282681 0.0263502 0.0258965 2.033980e+00 1.0870303 3.805850e+00 Zfp941 up
92 PPIL6 PPIL6 -0.8190445 0.3663250 -2.235841 0.0253622 0.0228182 0.0253622 0.0262949 4.408527e-01 0.2150191 9.038782e-01 Ppil6 up
67 MEIG1 MEIG1 -1.4153405 0.6416480 -2.205790 0.0273987 0.0165410 0.0273987 0.0263250 2.428429e-01 0.0690484 8.540773e-01 Meig1 up
41 FRY FRY -0.6736747 0.3074954 -2.190845 0.0284630 0.0283663 0.0284630 0.0281425 5.098316e-01 0.2790527 9.314667e-01 Fry up
24 CHST15 CHST15 -0.4167445 0.1902333 -2.190702 0.0284734 0.0278526 0.0284734 0.0281733 6.591893e-01 0.4540287 9.570553e-01 Chst15 up
19 CDH7 CDH7 -0.6616486 0.3054743 -2.165971 0.0303134 0.0216067 0.0303134 0.0286263 5.160000e-01 0.2835499 9.390093e-01 Cdh7 up
57 KNDC1 KNDC1 -0.2969632 0.1366881 -2.172560 0.0298134 0.0279141 0.0298134 0.0293196 7.430714e-01 0.5684358 9.713588e-01 Kndc1 up
125 TTC34 TTC34 -3.7733836 1.7457180 -2.161508 0.0306561 0.0235946 0.0306561 0.0297951 2.297420e-02 0.0007504 7.033933e-01 Ttc34 up
49 HHATL HHATL 0.2470745 0.1144943 2.157963 0.0309307 0.0303280 0.0309307 0.0308650 1.280274e+00 1.0229287 1.602363e+00 Hhatl up
53 KCNB1 KCNB1 -0.4829054 0.2251743 -2.144585 0.0319861 0.0281475 0.0319861 0.0316609 6.169882e-01 0.3968333 9.592804e-01 Kcnb1 up
51 HS6ST2 HS6ST2 0.8537621 0.4008883 2.129676 0.0331984 0.0357143 0.0331984 0.0317125 2.348466e+00 1.0704032 5.152535e+00 Hs6st2 up
126 TTLL11 TTLL11 1.3664702 0.6377193 2.142745 0.0321335 0.0412975 0.0321335 0.0321406 3.921484e+00 1.1236286 1.368605e+01 Ttll11 up
72 NLRP6 NLRP6 0.5442128 0.2548265 2.135621 0.0327103 0.0448962 0.0327103 0.0322133 1.723251e+00 1.0457789 2.839601e+00 Nlrp6 up
64 LUZP2 LUZP2 -0.3671389 0.1727341 -2.125457 0.0335485 0.0367364 0.0335485 0.0323780 6.927134e-01 0.4937670 9.718185e-01 Luzp2 up
10 BRINP1 BRINP1 -0.3392242 0.1600891 -2.118972 0.0340928 0.0305033 0.0340928 0.0324119 7.123227e-01 0.5204856 9.748658e-01 Brinp1 up
56 KLHDC9 KLHDC9 -0.2353128 0.1106619 -2.126413 0.0334689 0.0371299 0.0334689 0.0330566 7.903236e-01 0.6362230 9.817491e-01 Klhdc9 up
88 PLCB1 PLCB1 -0.6420079 0.3024846 -2.122448 0.0338001 0.0324093 0.0338001 0.0333069 5.262348e-01 0.2908735 9.520392e-01 Plcb1 up
105 SIDT1 SIDT1 -0.4174642 0.1983770 -2.104398 0.0353437 0.0278401 0.0353437 0.0339631 6.587150e-01 0.4465178 9.717541e-01 Sidt1 up
107 SLC1A2 SLC1A2 -0.2124443 0.1003561 -2.116904 0.0342680 0.0375824 0.0342680 0.0340428 8.086053e-01 0.6642221 9.843735e-01 Slc1a2 up
38 EMID1 EMID1 -0.4502308 0.2133506 -2.110287 0.0348337 0.0338802 0.0348337 0.0343860 6.374810e-01 0.4196265 9.684374e-01 Emid1 up
13 CACNA2D4 CACNA2D4 1.0245697 0.4891258 2.094696 0.0361980 0.0427101 0.0361980 0.0350024 2.785896e+00 1.0681207 7.266237e+00 Cacna2d4 up
76 NXPH3 NXPH3 -0.3774392 0.1806948 -2.088822 0.0367238 0.0409742 0.0367238 0.0363733 6.856149e-01 0.4811412 9.769850e-01 Nxph3 up
129 UNC13B UNC13B -0.7827685 0.3736143 -2.095125 0.0361599 0.0336327 0.0361599 0.0369294 4.571387e-01 0.2197996 9.507559e-01 Unc13b up
132 WNT9A WNT9A 0.6958626 0.3367280 2.066542 0.0387773 0.0463104 0.0387773 0.0378423 2.005438e+00 1.0365397 3.880008e+00 Wnt9a up
112 SMIM1 SMIM1 0.5206950 0.2527491 2.060126 0.0393865 0.0428917 0.0393865 0.0385225 1.683197e+00 1.0256390 2.762329e+00 Smim1 up
9 BAIAP3 BAIAP3 -0.2794113 0.1351514 -2.067396 0.0386969 0.0418946 0.0386969 0.0390339 7.562288e-01 0.5802460 9.855853e-01 Baiap3 up
33 DMKN DMKN -0.3291229 0.1606125 -2.049173 0.0404452 0.0368210 0.0404452 0.0393216 7.195546e-01 0.5252307 9.857741e-01 Dmkn up
115 SPRY3 SPRY3 0.4960903 0.2418322 2.051382 0.0402298 0.0386226 0.0402298 0.0404007 1.642288e+00 1.0223540 2.638136e+00 Spry3 up
2 ABHD3 ABHD3 0.5955091 0.2929307 2.032935 0.0420591 0.0407117 0.0420591 0.0409840 1.813954e+00 1.0216055 3.220842e+00 Abhd3 up
18 CD5L CD5L 0.7754014 0.3848963 2.014572 0.0439495 0.1129359 0.0439495 0.0414056 2.171464e+00 1.0212410 4.617181e+00 Cd5l down
58 LGI3 LGI3 0.1822722 0.0897599 2.030665 0.0422890 0.0443037 0.0422890 0.0414997 1.199941e+00 1.0063663 1.430749e+00 Lgi3 up
99 RSPO3 RSPO3 -0.6746499 0.3363098 -2.006037 0.0448523 0.0301619 0.0448523 0.0427121 5.093347e-01 0.2634728 9.846247e-01 Rspo3 up
32 DCHS2 DCHS2 -1.0486217 0.5210343 -2.012577 0.0441591 0.0349509 0.0441591 0.0427312 3.504204e-01 0.1262072 9.729591e-01 Dchs2 up
35 DNAH12 DNAH12 3.9025793 1.9420087 2.009558 0.0444780 0.0681526 0.0444780 0.0436603 4.953004e+01 1.1011029 2.227971e+03 Dnah12 up
31 CYB561 CYB561 -0.3508557 0.1754585 -1.999651 0.0455380 0.0350770 0.0455380 0.0445372 7.040854e-01 0.4992003 9.930608e-01 Cyb561 up
48 GPR176 GPR176 0.3455603 0.1729604 1.997916 0.0457257 0.0478815 0.0457257 0.0446132 1.412781e+00 1.0065858 1.982892e+00 Gpr176 up
34 DMRTC1 DMRTC1 98.5643120 49.8616264 1.976757 0.0480691 0.0630351 0.0480691 0.0448591 6.396418e+42 2.3101676 1.771047e+85 Dmrtc1a up
116 SPTBN5 SPTBN5 0.6025659 0.3021065 1.994548 0.0460922 0.0585582 0.0460922 0.0449381 1.826800e+00 1.0105029 3.302513e+00 Sptbn5 up
8 ARPP21 ARPP21 -0.3743726 0.1867061 -2.005144 0.0449477 0.0462126 0.0449477 0.0451881 6.877206e-01 0.4769661 9.916001e-01 Arpp21 up
7 ALDOC ALDOC -0.2765491 0.1381129 -2.002341 0.0452480 0.0542366 0.0452480 0.0455496 7.583964e-01 0.5785413 9.941643e-01 Aldoc up
23 CHST1 CHST1 -0.2144981 0.1081277 -1.983748 0.0472839 0.0521806 0.0472839 0.0467366 8.069463e-01 0.6528391 9.974316e-01 Chst1 up
131 WNT4 WNT4 -0.7042827 0.3598625 -1.957089 0.0503371 0.0247391 0.0503371 0.0469690 4.944631e-01 0.2442409 1.001035e+00 Wnt4 up
20 CDK6 CDK6 0.3824756 0.1938366 1.973185 0.0484744 0.0528413 0.0484744 0.0485995 1.465909e+00 1.0025661 2.143389e+00 Cdk6 down
97 RASGRF1 RASGRF1 -0.2693178 0.1370775 -1.964712 0.0494476 0.0439386 0.0494476 0.0487218 7.639004e-01 0.5839238 9.993493e-01 Rasgrf1 up
4 ADAMTS3 ADAMTS3 1.9769091 0.9586936 2.062086 0.0391995 0.0865033 0.0391995 0.0488657 7.220391e+00 1.1028571 4.727180e+01 Adamts3 up
119 SYT3 SYT3 -0.3410561 0.1739619 -1.960522 0.0499348 0.0391895 0.0499348 0.0489593 7.110190e-01 0.5055971 9.999029e-01 Syt3 up
81 PCDHGA4 PCDHGA4 1.0331251 0.5206786 1.984190 0.0472347 0.0638059 0.0472347 0.0497464 2.809833e+00 1.0126938 7.796199e+00 Pcdhga4 up
63 LSAMP LSAMP -0.6089189 0.3110885 -1.957382 0.0503026 0.0520013 0.0503026 0.0499826 5.439386e-01 0.2956316 1.000804e+00 Lsamp up

IDH_CODEL

Gene-sets considered

UP and DOWN

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Table genes

Variable Term Beta StandardError Z P LRT Wald LogRank HR HRlower HRupper mm status
47 GPR139 GPR139 2.9954716 0.5459944 5.486268 0.0000000 0.0000008 0.0000000 0.0000000 1.999479e+01 6.8574946 5.829993e+01 Gpr139 up
11 BVES BVES 0.7842063 0.1424517 5.505070 0.0000000 0.0000025 0.0000000 0.0000001 2.190667e+00 1.6569958 2.896220e+00 Bves up
22 CHIC2 CHIC2 1.1744777 0.2267115 5.180495 0.0000002 0.0000079 0.0000002 0.0000002 3.236452e+00 2.0753531 5.047152e+00 Chic2 down
62 LRRK2 LRRK2 0.6724442 0.1341983 5.010825 0.0000005 0.0000059 0.0000005 0.0000002 1.959020e+00 1.5059447 2.548406e+00 Lrrk2 up
21 CEP135 CEP135 1.1901584 0.2479228 4.800520 0.0000016 0.0000491 0.0000016 0.0000014 3.287602e+00 2.0223064 5.344554e+00 Cep135 down
133 ZBTB8B ZBTB8B 1.1045218 0.2349319 4.701455 0.0000026 0.0000192 0.0000026 0.0000022 3.017781e+00 1.9042034 4.782579e+00 Zbtb8b up
86 PI4K2B PI4K2B 1.0371524 0.2498474 4.151143 0.0000331 0.0015532 0.0000331 0.0000217 2.821172e+00 1.7288568 4.603626e+00 Pi4k2b down
102 SERINC2 SERINC2 0.6263722 0.1610620 3.889012 0.0001007 0.0002453 0.0001007 0.0000827 1.870811e+00 1.3643749 2.565230e+00 Serinc2 up
104 SH3GL2 SH3GL2 -0.7907620 0.2005988 -3.942008 0.0000808 0.0000695 0.0000808 0.0001115 4.534991e-01 0.3060740 6.719337e-01 Sh3gl2 up
15 CCDC87 CCDC87 -0.7788043 0.2036870 -3.823535 0.0001316 0.0001516 0.0001316 0.0001223 4.589545e-01 0.3078867 6.841452e-01 Ccdc87 up
80 PCDHGA3 PCDHGA3 0.6336887 0.1854916 3.416266 0.0006349 0.0047731 0.0006349 0.0001990 1.884549e+00 1.3101371 2.710805e+00 Pcdhga3 up
101 SEPSECS SEPSECS 1.0745060 0.2684215 4.003055 0.0000625 0.0004790 0.0000625 0.0002610 2.928546e+00 1.7304985 4.956017e+00 Sepsecs down
78 PAX5 PAX5 4.3732708 1.3013911 3.360458 0.0007781 0.0111408 0.0007781 0.0002911 7.930259e+01 6.1878707 1.016327e+03 Pax5 down
54 KCNG1 KCNG1 -0.5347163 0.1540201 -3.471731 0.0005171 0.0001938 0.0005171 0.0004520 5.858355e-01 0.4331851 7.922784e-01 Kcng1 up
85 PHKG1 PHKG1 -0.3998301 0.1165522 -3.430480 0.0006025 0.0009269 0.0006025 0.0004617 6.704339e-01 0.5335149 8.424913e-01 Phkg1 up
50 HHIP HHIP 0.5367070 0.1575686 3.406179 0.0006588 0.0014311 0.0006588 0.0005304 1.710365e+00 1.2559323 2.329225e+00 Hhip up
36 EFCAB6 EFCAB6 -7.0065194 2.0604116 -3.400543 0.0006725 0.0002490 0.0006725 0.0005886 9.060000e-04 0.0000160 5.139640e-02 Efcab6 up
68 METTL11B METTL11B 2.6216611 0.8373169 3.131026 0.0017420 0.0097680 0.0017420 0.0007621 1.375856e+01 2.6659224 7.100655e+01 Mettl11b up
89 PLCXD1 PLCXD1 0.6979770 0.2051305 3.402601 0.0006675 0.0009493 0.0006675 0.0007977 2.009683e+00 1.3443743 3.004242e+00 Plcxd1 up
25 CLEC18A CLEC18A 2.0090652 0.6175386 3.253344 0.0011406 0.0037224 0.0011406 0.0009366 7.456344e+00 2.2226761 2.501357e+01 Clec18a up
82 PCDHGA8 PCDHGA8 4.5064285 1.4663795 3.073167 0.0021180 0.0114419 0.0021180 0.0016940 9.059767e+01 5.1160230 1.604359e+03 Pcdhga8 up
79 PCDH7 PCDH7 -0.7147787 0.2368258 -3.018163 0.0025431 0.0019136 0.0025431 0.0024481 4.893004e-01 0.3076020 7.783268e-01 Pcdh7 up
17 CCNB2 CCNB2 0.3221457 0.1089420 2.957039 0.0031061 0.0046368 0.0031061 0.0027830 1.380086e+00 1.1147424 1.708589e+00 Ccnb2 down
1 ABCA8 ABCA8 0.4256288 0.1413422 3.011336 0.0026010 0.0059862 0.0026010 0.0030725 1.530552e+00 1.1602125 2.019105e+00 Abca8b up
43 GDF10 GDF10 -0.3061819 0.1055962 -2.899555 0.0037369 0.0022250 0.0037369 0.0032660 7.362527e-01 0.5986090 9.055460e-01 Gdf10 up
44 GJA1 GJA1 -0.4050831 0.1380017 -2.935349 0.0033317 0.0035724 0.0033317 0.0034714 6.669214e-01 0.5088706 8.740613e-01 Gja1 up
29 CRTAC1 CRTAC1 -0.5539521 0.1912721 -2.896147 0.0037778 0.0040257 0.0037778 0.0037843 5.746742e-01 0.3950123 8.360510e-01 Crtac1 up
74 NRG3 NRG3 -2.4032161 0.8375289 -2.869413 0.0041123 0.0031459 0.0041123 0.0039243 9.042670e-02 0.0175142 4.668770e-01 Nrg3 up
123 TPSAB1 TPSAB1 -0.7426437 0.2748043 -2.702446 0.0068831 0.0004653 0.0068831 0.0039419 4.758542e-01 0.2776899 8.154320e-01 Tpsb2 down
128 TUB TUB -0.5196510 0.1808249 -2.873780 0.0040559 0.0047320 0.0040559 0.0041056 5.947281e-01 0.4172535 8.476897e-01 Tub up
103 SFTPC SFTPC 0.4223342 0.1487355 2.839498 0.0045185 0.0058762 0.0045185 0.0041667 1.525518e+00 1.1397603 2.041838e+00 Sftpc up
120 TCHH TCHH -0.5988549 0.2142769 -2.794771 0.0051936 0.0025865 0.0051936 0.0050215 5.494404e-01 0.3610171 8.362064e-01 Tchh up
130 VWC2 VWC2 -0.8118496 0.2985573 -2.719242 0.0065432 0.0042834 0.0065432 0.0057806 4.440360e-01 0.2473351 7.971695e-01 Vwc2 up
27 CNGA4 CNGA4 -1.0359853 0.3821171 -2.711172 0.0067046 0.0040296 0.0067046 0.0063590 3.548765e-01 0.1678103 7.504746e-01 Cnga4 up
114 SPHKAP SPHKAP -0.4625777 0.1721975 -2.686321 0.0072244 0.0065275 0.0072244 0.0068047 6.296585e-01 0.4492936 8.824291e-01 Sphkap up
46 GLT8D2 GLT8D2 -1.6440659 0.6170412 -2.664435 0.0077118 0.0045787 0.0077118 0.0071151 1.931929e-01 0.0576454 6.474670e-01 Glt8d2 up
40 FAM186B FAM186B 2.7648858 1.0270985 2.691938 0.0071038 0.0102688 0.0071038 0.0071928 1.587723e+01 2.1208349 1.188618e+02 Fam186b up
5 ADCY2 ADCY2 -0.5091532 0.1915128 -2.658586 0.0078469 0.0086014 0.0078469 0.0075234 6.010043e-01 0.4129159 8.747693e-01 Adcy2 up
87 PLA2G4E PLA2G4E 19.0823473 7.2463960 2.633357 0.0084545 0.0379296 0.0084545 0.0081310 1.938019e+08 131.5875091 2.854313e+14 Pla2g4e up
96 RAB42 RAB42 0.5038644 0.1915025 2.631111 0.0085106 0.0086515 0.0085106 0.0084776 1.655105e+00 1.1371513 2.408978e+00 Rab42 up
73 NR3C2 NR3C2 -1.1889369 0.4523989 -2.628072 0.0085870 0.0066070 0.0085870 0.0085969 3.045449e-01 0.1254783 7.391523e-01 Nr3c2 up
60 LRRC18 LRRC18 0.8248612 0.3172093 2.600369 0.0093124 0.0202333 0.0093124 0.0094480 2.281564e+00 1.2252469 4.248560e+00 Lrrc18 up
66 MAP6D1 MAP6D1 0.3520670 0.1365555 2.578198 0.0099317 0.0104100 0.0099317 0.0094586 1.422004e+00 1.0880893 1.858390e+00 Map6d1 up
69 MGAT4C MGAT4C -1.3821722 0.5241332 -2.637063 0.0083627 0.0040005 0.0083627 0.0095399 2.510327e-01 0.0898643 7.012506e-01 Mgat4c up
106 SLAIN2 SLAIN2 0.8455718 0.3292619 2.568083 0.0102263 0.0111327 0.0102263 0.0096223 2.329309e+00 1.2216841 4.441149e+00 Slain2 down
113 SPAG17 SPAG17 10.0872014 4.2371258 2.380671 0.0172812 0.0574988 0.0172812 0.0110288 2.403344e+04 5.9452191 9.715474e+07 Spag17 up
37 EFEMP1 EFEMP1 -0.2914440 0.1149583 -2.535214 0.0112379 0.0122232 0.0112379 0.0111204 7.471839e-01 0.5964510 9.360093e-01 Efemp1 up
12 CACNA2D2 CACNA2D2 -0.8043295 0.3205444 -2.509261 0.0120984 0.0098839 0.0120984 0.0118147 4.473878e-01 0.2386911 8.385559e-01 Cacna2d2 up
55 KLF14 KLF14 1.6071670 0.6370812 2.522703 0.0116457 0.0346226 0.0116457 0.0119965 4.988658e+00 1.4311964 1.738875e+01 Klf14 up
127 TTLL7 TTLL7 0.4510948 0.1808449 2.494374 0.0126179 0.0140847 0.0126179 0.0121624 1.570030e+00 1.1014697 2.237914e+00 Ttll7 up
28 CPA3 CPA3 -2.6676371 1.2839007 -2.077760 0.0377315 0.0010779 0.0377315 0.0122039 6.941610e-02 0.0056053 8.596431e-01 Cpa3 down
94 PRIMA1 PRIMA1 0.6222890 0.2488279 2.500881 0.0123885 0.0134312 0.0123885 0.0122378 1.863188e+00 1.1440737 3.034306e+00 Prima1 up
110 SLC7A11 SLC7A11 -0.5173928 0.2068672 -2.501087 0.0123813 0.0111473 0.0123813 0.0128561 5.960726e-01 0.3973869 8.940974e-01 Slc7a11 up
83 PDGFRA PDGFRA 0.3197732 0.1282574 2.493214 0.0126593 0.0114151 0.0126593 0.0129613 1.376815e+00 1.0707863 1.770307e+00 Pdgfra down
65 MAGEE2 MAGEE2 0.2072085 0.0847911 2.443752 0.0145354 0.0121291 0.0145354 0.0129998 1.230239e+00 1.0418739 1.452659e+00 Magee2 up
26 CLMN CLMN 0.5914685 0.2374123 2.491314 0.0127272 0.0186262 0.0127272 0.0131366 1.806639e+00 1.1344511 2.877115e+00 Clmn up
93 PPP2R2B PPP2R2B -0.7571162 0.3070699 -2.465615 0.0136778 0.0122080 0.0136778 0.0135049 4.690170e-01 0.2569273 8.561837e-01 Ppp2r2b up
70 MSR1 MSR1 0.6293928 0.2584362 2.435390 0.0148758 0.0257520 0.0148758 0.0144026 1.876471e+00 1.1307343 3.114032e+00 Msr1 down
16 CCL27 CCL27 -10.1807420 4.9394362 -2.061114 0.0392921 0.0011244 0.0392921 0.0147958 3.790000e-05 0.0000000 6.067582e-01 Ccl27a up
111 SLITRK5 SLITRK5 -0.4852339 0.1987193 -2.441806 0.0146140 0.0166802 0.0146140 0.0148097 6.155532e-01 0.4169802 9.086900e-01 Slitrk5 up
121 TFCP2L1 TFCP2L1 0.4640884 0.1932673 2.401277 0.0163379 0.0254705 0.0163379 0.0148488 1.590564e+00 1.0890344 2.323060e+00 Tfcp2l1 up
100 SCUBE3 SCUBE3 0.5114631 0.2125001 2.406884 0.0160893 0.0256815 0.0160893 0.0148709 1.667729e+00 1.0996264 2.529333e+00 Scube3 up
134 ZCCHC3 ZCCHC3 0.8449587 0.3501292 2.413277 0.0158098 0.0144719 0.0158098 0.0157013 2.327882e+00 1.1720075 4.623719e+00 Zcchc3 up
6 AHCYL2 AHCYL2 -0.4618186 0.1916865 -2.409239 0.0159858 0.0144949 0.0159858 0.0157534 6.301366e-01 0.4327837 9.174842e-01 Ahcyl2 up
84 PELI3 PELI3 -0.5361502 0.2219673 -2.415447 0.0157159 0.0125532 0.0157159 0.0158807 5.849960e-01 0.3786292 9.038405e-01 Peli3 up
117 SYT12 SYT12 -0.3974626 0.1658915 -2.395919 0.0165787 0.0103877 0.0165787 0.0161174 6.720231e-01 0.4854864 9.302320e-01 Syt12 up
61 LRRC6 LRRC6 -1.2100537 0.5083194 -2.380499 0.0172892 0.0148202 0.0172892 0.0162693 2.981813e-01 0.1101027 8.075373e-01 Lrrc6 up
77 OSR1 OSR1 0.2144682 0.0905432 2.368683 0.0178516 0.0251440 0.0178516 0.0166777 1.239203e+00 1.0377000 1.479834e+00 Osr1 up
90 PLK5 PLK5 -0.5414021 0.2291631 -2.362518 0.0181512 0.0166165 0.0181512 0.0175387 5.819318e-01 0.3713711 9.118766e-01 Plk5 up
59 LIX1 LIX1 -0.2840070 0.1205932 -2.355083 0.0185186 0.0237242 0.0185186 0.0177018 7.527614e-01 0.5943034 9.534687e-01 Lix1 up
45 GLRA3 GLRA3 -0.6180356 0.2634646 -2.345801 0.0189862 0.0133041 0.0189862 0.0185040 5.390022e-01 0.3216097 9.033416e-01 Glra3 up
71 NIPAL3 NIPAL3 0.3068599 0.1315510 2.332631 0.0196675 0.0202769 0.0196675 0.0189767 1.359150e+00 1.0502462 1.758911e+00 Nipal3 up
75 NSUN7 NSUN7 2.8988354 1.2476243 2.323484 0.0201532 0.0274793 0.0201532 0.0194083 1.815299e+01 1.5738687 2.093765e+02 Nsun7 up
3 ABLIM3 ABLIM3 -0.4204272 0.1804536 -2.329836 0.0198148 0.0196918 0.0198148 0.0196757 6.567662e-01 0.4611141 9.354340e-01 Ablim3 up
98 RNF32 RNF32 -0.7549155 0.3244026 -2.327095 0.0199602 0.0195812 0.0199602 0.0197767 4.700503e-01 0.2488928 8.877207e-01 Rnf32 up
30 CRYBB1 CRYBB1 -0.6109657 0.2598025 -2.351655 0.0186901 0.0162412 0.0186901 0.0199216 5.428264e-01 0.3262246 9.032443e-01 Crybb1 up
122 TNNI1 TNNI1 2.8923203 1.3335905 2.168822 0.0300962 0.0799377 0.0300962 0.0199732 1.803511e+01 1.3211876 2.461915e+02 Tnni1 up
91 POPDC3 POPDC3 0.3123546 0.1361879 2.293555 0.0218161 0.0284385 0.0218161 0.0201892 1.366639e+00 1.0464789 1.784749e+00 Popdc3 up
14 CAMSAP3 CAMSAP3 -0.2662145 0.1163447 -2.288152 0.0221286 0.0232764 0.0221286 0.0215514 7.662747e-01 0.6100307 9.625368e-01 Camsap3 up
42 FZD2 FZD2 0.3875964 0.1688566 2.295418 0.0217092 0.0214499 0.0217092 0.0216465 1.473435e+00 1.0582785 2.051455e+00 Fzd2 up
135 ZCCHC4 ZCCHC4 0.7571164 0.3109674 2.434713 0.0149036 0.0324878 0.0149036 0.0221649 2.132119e+00 1.1590857 3.921998e+00 Zcchc4 down
124 TPSB2 TPSB2 -0.4678065 0.2090684 -2.237576 0.0252487 0.0102559 0.0252487 0.0225107 6.263747e-01 0.4157908 9.436123e-01 Tpsb2 down
109 SLC4A4 SLC4A4 -0.4141597 0.1824616 -2.269846 0.0232169 0.0246088 0.0232169 0.0226269 6.608954e-01 0.4621906 9.450271e-01 Slc4a4 up
52 HTR2C HTR2C -3.1565775 1.3995778 -2.255378 0.0241096 0.0133067 0.0241096 0.0232918 4.257120e-02 0.0027403 6.613610e-01 Htr2c up
108 SLC35F4 SLC35F4 6.9660928 3.4145385 2.040127 0.0413377 0.1207829 0.0413377 0.0234941 1.060073e+03 1.3148471 8.546653e+05 Slc35f4 up
39 FAM111A FAM111A 0.4931808 0.2189509 2.252472 0.0242925 0.0261799 0.0242925 0.0238429 1.637517e+00 1.0661403 2.515110e+00 Fam111a down
118 SYT17 SYT17 -0.6691720 0.2974328 -2.249826 0.0244600 0.0230309 0.0244600 0.0240354 5.121324e-01 0.2858953 9.173975e-01 Syt17 up
95 PROK2 PROK2 1.8148931 0.8212733 2.209853 0.0271154 0.0412250 0.0271154 0.0258169 6.140420e+00 1.2278037 3.070911e+01 Prok2 up
136 ZNF519 ZNF519 0.7099944 0.3196717 2.221011 0.0263502 0.0282681 0.0263502 0.0258965 2.033980e+00 1.0870303 3.805850e+00 Zfp941 up
92 PPIL6 PPIL6 -0.8190445 0.3663250 -2.235841 0.0253622 0.0228182 0.0253622 0.0262949 4.408527e-01 0.2150191 9.038782e-01 Ppil6 up
67 MEIG1 MEIG1 -1.4153405 0.6416480 -2.205790 0.0273987 0.0165410 0.0273987 0.0263250 2.428429e-01 0.0690484 8.540773e-01 Meig1 up
41 FRY FRY -0.6736747 0.3074954 -2.190845 0.0284630 0.0283663 0.0284630 0.0281425 5.098316e-01 0.2790527 9.314667e-01 Fry up
24 CHST15 CHST15 -0.4167445 0.1902333 -2.190702 0.0284734 0.0278526 0.0284734 0.0281733 6.591893e-01 0.4540287 9.570553e-01 Chst15 up
19 CDH7 CDH7 -0.6616486 0.3054743 -2.165971 0.0303134 0.0216067 0.0303134 0.0286263 5.160000e-01 0.2835499 9.390093e-01 Cdh7 up
57 KNDC1 KNDC1 -0.2969632 0.1366881 -2.172560 0.0298134 0.0279141 0.0298134 0.0293196 7.430714e-01 0.5684358 9.713588e-01 Kndc1 up
125 TTC34 TTC34 -3.7733836 1.7457180 -2.161508 0.0306561 0.0235946 0.0306561 0.0297951 2.297420e-02 0.0007504 7.033933e-01 Ttc34 up
49 HHATL HHATL 0.2470745 0.1144943 2.157963 0.0309307 0.0303280 0.0309307 0.0308650 1.280274e+00 1.0229287 1.602363e+00 Hhatl up
53 KCNB1 KCNB1 -0.4829054 0.2251743 -2.144585 0.0319861 0.0281475 0.0319861 0.0316609 6.169882e-01 0.3968333 9.592804e-01 Kcnb1 up
51 HS6ST2 HS6ST2 0.8537621 0.4008883 2.129676 0.0331984 0.0357143 0.0331984 0.0317125 2.348466e+00 1.0704032 5.152535e+00 Hs6st2 up
126 TTLL11 TTLL11 1.3664702 0.6377193 2.142745 0.0321335 0.0412975 0.0321335 0.0321406 3.921484e+00 1.1236286 1.368605e+01 Ttll11 up
72 NLRP6 NLRP6 0.5442128 0.2548265 2.135621 0.0327103 0.0448962 0.0327103 0.0322133 1.723251e+00 1.0457789 2.839601e+00 Nlrp6 up
64 LUZP2 LUZP2 -0.3671389 0.1727341 -2.125457 0.0335485 0.0367364 0.0335485 0.0323780 6.927134e-01 0.4937670 9.718185e-01 Luzp2 up
10 BRINP1 BRINP1 -0.3392242 0.1600891 -2.118972 0.0340928 0.0305033 0.0340928 0.0324119 7.123227e-01 0.5204856 9.748658e-01 Brinp1 up
56 KLHDC9 KLHDC9 -0.2353128 0.1106619 -2.126413 0.0334689 0.0371299 0.0334689 0.0330566 7.903236e-01 0.6362230 9.817491e-01 Klhdc9 up
88 PLCB1 PLCB1 -0.6420079 0.3024846 -2.122448 0.0338001 0.0324093 0.0338001 0.0333069 5.262348e-01 0.2908735 9.520392e-01 Plcb1 up
105 SIDT1 SIDT1 -0.4174642 0.1983770 -2.104398 0.0353437 0.0278401 0.0353437 0.0339631 6.587150e-01 0.4465178 9.717541e-01 Sidt1 up
107 SLC1A2 SLC1A2 -0.2124443 0.1003561 -2.116904 0.0342680 0.0375824 0.0342680 0.0340428 8.086053e-01 0.6642221 9.843735e-01 Slc1a2 up
38 EMID1 EMID1 -0.4502308 0.2133506 -2.110287 0.0348337 0.0338802 0.0348337 0.0343860 6.374810e-01 0.4196265 9.684374e-01 Emid1 up
13 CACNA2D4 CACNA2D4 1.0245697 0.4891258 2.094696 0.0361980 0.0427101 0.0361980 0.0350024 2.785896e+00 1.0681207 7.266237e+00 Cacna2d4 up
76 NXPH3 NXPH3 -0.3774392 0.1806948 -2.088822 0.0367238 0.0409742 0.0367238 0.0363733 6.856149e-01 0.4811412 9.769850e-01 Nxph3 up
129 UNC13B UNC13B -0.7827685 0.3736143 -2.095125 0.0361599 0.0336327 0.0361599 0.0369294 4.571387e-01 0.2197996 9.507559e-01 Unc13b up
132 WNT9A WNT9A 0.6958626 0.3367280 2.066542 0.0387773 0.0463104 0.0387773 0.0378423 2.005438e+00 1.0365397 3.880008e+00 Wnt9a up
112 SMIM1 SMIM1 0.5206950 0.2527491 2.060126 0.0393865 0.0428917 0.0393865 0.0385225 1.683197e+00 1.0256390 2.762329e+00 Smim1 up
9 BAIAP3 BAIAP3 -0.2794113 0.1351514 -2.067396 0.0386969 0.0418946 0.0386969 0.0390339 7.562288e-01 0.5802460 9.855853e-01 Baiap3 up
33 DMKN DMKN -0.3291229 0.1606125 -2.049173 0.0404452 0.0368210 0.0404452 0.0393216 7.195546e-01 0.5252307 9.857741e-01 Dmkn up
115 SPRY3 SPRY3 0.4960903 0.2418322 2.051382 0.0402298 0.0386226 0.0402298 0.0404007 1.642288e+00 1.0223540 2.638136e+00 Spry3 up
2 ABHD3 ABHD3 0.5955091 0.2929307 2.032935 0.0420591 0.0407117 0.0420591 0.0409840 1.813954e+00 1.0216055 3.220842e+00 Abhd3 up
18 CD5L CD5L 0.7754014 0.3848963 2.014572 0.0439495 0.1129359 0.0439495 0.0414056 2.171464e+00 1.0212410 4.617181e+00 Cd5l down
58 LGI3 LGI3 0.1822722 0.0897599 2.030665 0.0422890 0.0443037 0.0422890 0.0414997 1.199941e+00 1.0063663 1.430749e+00 Lgi3 up
99 RSPO3 RSPO3 -0.6746499 0.3363098 -2.006037 0.0448523 0.0301619 0.0448523 0.0427121 5.093347e-01 0.2634728 9.846247e-01 Rspo3 up
32 DCHS2 DCHS2 -1.0486217 0.5210343 -2.012577 0.0441591 0.0349509 0.0441591 0.0427312 3.504204e-01 0.1262072 9.729591e-01 Dchs2 up
35 DNAH12 DNAH12 3.9025793 1.9420087 2.009558 0.0444780 0.0681526 0.0444780 0.0436603 4.953004e+01 1.1011029 2.227971e+03 Dnah12 up
31 CYB561 CYB561 -0.3508557 0.1754585 -1.999651 0.0455380 0.0350770 0.0455380 0.0445372 7.040854e-01 0.4992003 9.930608e-01 Cyb561 up
48 GPR176 GPR176 0.3455603 0.1729604 1.997916 0.0457257 0.0478815 0.0457257 0.0446132 1.412781e+00 1.0065858 1.982892e+00 Gpr176 up
34 DMRTC1 DMRTC1 98.5643120 49.8616264 1.976757 0.0480691 0.0630351 0.0480691 0.0448591 6.396418e+42 2.3101676 1.771047e+85 Dmrtc1a up
116 SPTBN5 SPTBN5 0.6025659 0.3021065 1.994548 0.0460922 0.0585582 0.0460922 0.0449381 1.826800e+00 1.0105029 3.302513e+00 Sptbn5 up
8 ARPP21 ARPP21 -0.3743726 0.1867061 -2.005144 0.0449477 0.0462126 0.0449477 0.0451881 6.877206e-01 0.4769661 9.916001e-01 Arpp21 up
7 ALDOC ALDOC -0.2765491 0.1381129 -2.002341 0.0452480 0.0542366 0.0452480 0.0455496 7.583964e-01 0.5785413 9.941643e-01 Aldoc up
23 CHST1 CHST1 -0.2144981 0.1081277 -1.983748 0.0472839 0.0521806 0.0472839 0.0467366 8.069463e-01 0.6528391 9.974316e-01 Chst1 up
131 WNT4 WNT4 -0.7042827 0.3598625 -1.957089 0.0503371 0.0247391 0.0503371 0.0469690 4.944631e-01 0.2442409 1.001035e+00 Wnt4 up
20 CDK6 CDK6 0.3824756 0.1938366 1.973185 0.0484744 0.0528413 0.0484744 0.0485995 1.465909e+00 1.0025661 2.143389e+00 Cdk6 down
97 RASGRF1 RASGRF1 -0.2693178 0.1370775 -1.964712 0.0494476 0.0439386 0.0494476 0.0487218 7.639004e-01 0.5839238 9.993493e-01 Rasgrf1 up
4 ADAMTS3 ADAMTS3 1.9769091 0.9586936 2.062086 0.0391995 0.0865033 0.0391995 0.0488657 7.220391e+00 1.1028571 4.727180e+01 Adamts3 up
119 SYT3 SYT3 -0.3410561 0.1739619 -1.960522 0.0499348 0.0391895 0.0499348 0.0489593 7.110190e-01 0.5055971 9.999029e-01 Syt3 up
81 PCDHGA4 PCDHGA4 1.0331251 0.5206786 1.984190 0.0472347 0.0638059 0.0472347 0.0497464 2.809833e+00 1.0126938 7.796199e+00 Pcdhga4 up
63 LSAMP LSAMP -0.6089189 0.3110885 -1.957382 0.0503026 0.0520013 0.0503026 0.0499826 5.439386e-01 0.2956316 1.000804e+00 Lsamp up

IDH_NOCODEL

Gene-sets considered

UP and DOWN

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Table genes

Variable Term Beta StandardError Z P LRT Wald LogRank HR HRlower HRupper mm status
47 GPR139 GPR139 2.9954716 0.5459944 5.486268 0.0000000 0.0000008 0.0000000 0.0000000 1.999479e+01 6.8574946 5.829993e+01 Gpr139 up
11 BVES BVES 0.7842063 0.1424517 5.505070 0.0000000 0.0000025 0.0000000 0.0000001 2.190667e+00 1.6569958 2.896220e+00 Bves up
22 CHIC2 CHIC2 1.1744777 0.2267115 5.180495 0.0000002 0.0000079 0.0000002 0.0000002 3.236452e+00 2.0753531 5.047152e+00 Chic2 down
62 LRRK2 LRRK2 0.6724442 0.1341983 5.010825 0.0000005 0.0000059 0.0000005 0.0000002 1.959020e+00 1.5059447 2.548406e+00 Lrrk2 up
21 CEP135 CEP135 1.1901584 0.2479228 4.800520 0.0000016 0.0000491 0.0000016 0.0000014 3.287602e+00 2.0223064 5.344554e+00 Cep135 down
133 ZBTB8B ZBTB8B 1.1045218 0.2349319 4.701455 0.0000026 0.0000192 0.0000026 0.0000022 3.017781e+00 1.9042034 4.782579e+00 Zbtb8b up
86 PI4K2B PI4K2B 1.0371524 0.2498474 4.151143 0.0000331 0.0015532 0.0000331 0.0000217 2.821172e+00 1.7288568 4.603626e+00 Pi4k2b down
102 SERINC2 SERINC2 0.6263722 0.1610620 3.889012 0.0001007 0.0002453 0.0001007 0.0000827 1.870811e+00 1.3643749 2.565230e+00 Serinc2 up
104 SH3GL2 SH3GL2 -0.7907620 0.2005988 -3.942008 0.0000808 0.0000695 0.0000808 0.0001115 4.534991e-01 0.3060740 6.719337e-01 Sh3gl2 up
15 CCDC87 CCDC87 -0.7788043 0.2036870 -3.823535 0.0001316 0.0001516 0.0001316 0.0001223 4.589545e-01 0.3078867 6.841452e-01 Ccdc87 up
80 PCDHGA3 PCDHGA3 0.6336887 0.1854916 3.416266 0.0006349 0.0047731 0.0006349 0.0001990 1.884549e+00 1.3101371 2.710805e+00 Pcdhga3 up
101 SEPSECS SEPSECS 1.0745060 0.2684215 4.003055 0.0000625 0.0004790 0.0000625 0.0002610 2.928546e+00 1.7304985 4.956017e+00 Sepsecs down
78 PAX5 PAX5 4.3732708 1.3013911 3.360458 0.0007781 0.0111408 0.0007781 0.0002911 7.930259e+01 6.1878707 1.016327e+03 Pax5 down
54 KCNG1 KCNG1 -0.5347163 0.1540201 -3.471731 0.0005171 0.0001938 0.0005171 0.0004520 5.858355e-01 0.4331851 7.922784e-01 Kcng1 up
85 PHKG1 PHKG1 -0.3998301 0.1165522 -3.430480 0.0006025 0.0009269 0.0006025 0.0004617 6.704339e-01 0.5335149 8.424913e-01 Phkg1 up
50 HHIP HHIP 0.5367070 0.1575686 3.406179 0.0006588 0.0014311 0.0006588 0.0005304 1.710365e+00 1.2559323 2.329225e+00 Hhip up
36 EFCAB6 EFCAB6 -7.0065194 2.0604116 -3.400543 0.0006725 0.0002490 0.0006725 0.0005886 9.060000e-04 0.0000160 5.139640e-02 Efcab6 up
68 METTL11B METTL11B 2.6216611 0.8373169 3.131026 0.0017420 0.0097680 0.0017420 0.0007621 1.375856e+01 2.6659224 7.100655e+01 Mettl11b up
89 PLCXD1 PLCXD1 0.6979770 0.2051305 3.402601 0.0006675 0.0009493 0.0006675 0.0007977 2.009683e+00 1.3443743 3.004242e+00 Plcxd1 up
25 CLEC18A CLEC18A 2.0090652 0.6175386 3.253344 0.0011406 0.0037224 0.0011406 0.0009366 7.456344e+00 2.2226761 2.501357e+01 Clec18a up
82 PCDHGA8 PCDHGA8 4.5064285 1.4663795 3.073167 0.0021180 0.0114419 0.0021180 0.0016940 9.059767e+01 5.1160230 1.604359e+03 Pcdhga8 up
79 PCDH7 PCDH7 -0.7147787 0.2368258 -3.018163 0.0025431 0.0019136 0.0025431 0.0024481 4.893004e-01 0.3076020 7.783268e-01 Pcdh7 up
17 CCNB2 CCNB2 0.3221457 0.1089420 2.957039 0.0031061 0.0046368 0.0031061 0.0027830 1.380086e+00 1.1147424 1.708589e+00 Ccnb2 down
1 ABCA8 ABCA8 0.4256288 0.1413422 3.011336 0.0026010 0.0059862 0.0026010 0.0030725 1.530552e+00 1.1602125 2.019105e+00 Abca8b up
43 GDF10 GDF10 -0.3061819 0.1055962 -2.899555 0.0037369 0.0022250 0.0037369 0.0032660 7.362527e-01 0.5986090 9.055460e-01 Gdf10 up
44 GJA1 GJA1 -0.4050831 0.1380017 -2.935349 0.0033317 0.0035724 0.0033317 0.0034714 6.669214e-01 0.5088706 8.740613e-01 Gja1 up
29 CRTAC1 CRTAC1 -0.5539521 0.1912721 -2.896147 0.0037778 0.0040257 0.0037778 0.0037843 5.746742e-01 0.3950123 8.360510e-01 Crtac1 up
74 NRG3 NRG3 -2.4032161 0.8375289 -2.869413 0.0041123 0.0031459 0.0041123 0.0039243 9.042670e-02 0.0175142 4.668770e-01 Nrg3 up
123 TPSAB1 TPSAB1 -0.7426437 0.2748043 -2.702446 0.0068831 0.0004653 0.0068831 0.0039419 4.758542e-01 0.2776899 8.154320e-01 Tpsb2 down
128 TUB TUB -0.5196510 0.1808249 -2.873780 0.0040559 0.0047320 0.0040559 0.0041056 5.947281e-01 0.4172535 8.476897e-01 Tub up
103 SFTPC SFTPC 0.4223342 0.1487355 2.839498 0.0045185 0.0058762 0.0045185 0.0041667 1.525518e+00 1.1397603 2.041838e+00 Sftpc up
120 TCHH TCHH -0.5988549 0.2142769 -2.794771 0.0051936 0.0025865 0.0051936 0.0050215 5.494404e-01 0.3610171 8.362064e-01 Tchh up
130 VWC2 VWC2 -0.8118496 0.2985573 -2.719242 0.0065432 0.0042834 0.0065432 0.0057806 4.440360e-01 0.2473351 7.971695e-01 Vwc2 up
27 CNGA4 CNGA4 -1.0359853 0.3821171 -2.711172 0.0067046 0.0040296 0.0067046 0.0063590 3.548765e-01 0.1678103 7.504746e-01 Cnga4 up
114 SPHKAP SPHKAP -0.4625777 0.1721975 -2.686321 0.0072244 0.0065275 0.0072244 0.0068047 6.296585e-01 0.4492936 8.824291e-01 Sphkap up
46 GLT8D2 GLT8D2 -1.6440659 0.6170412 -2.664435 0.0077118 0.0045787 0.0077118 0.0071151 1.931929e-01 0.0576454 6.474670e-01 Glt8d2 up
40 FAM186B FAM186B 2.7648858 1.0270985 2.691938 0.0071038 0.0102688 0.0071038 0.0071928 1.587723e+01 2.1208349 1.188618e+02 Fam186b up
5 ADCY2 ADCY2 -0.5091532 0.1915128 -2.658586 0.0078469 0.0086014 0.0078469 0.0075234 6.010043e-01 0.4129159 8.747693e-01 Adcy2 up
87 PLA2G4E PLA2G4E 19.0823473 7.2463960 2.633357 0.0084545 0.0379296 0.0084545 0.0081310 1.938019e+08 131.5875091 2.854313e+14 Pla2g4e up
96 RAB42 RAB42 0.5038644 0.1915025 2.631111 0.0085106 0.0086515 0.0085106 0.0084776 1.655105e+00 1.1371513 2.408978e+00 Rab42 up
73 NR3C2 NR3C2 -1.1889369 0.4523989 -2.628072 0.0085870 0.0066070 0.0085870 0.0085969 3.045449e-01 0.1254783 7.391523e-01 Nr3c2 up
60 LRRC18 LRRC18 0.8248612 0.3172093 2.600369 0.0093124 0.0202333 0.0093124 0.0094480 2.281564e+00 1.2252469 4.248560e+00 Lrrc18 up
66 MAP6D1 MAP6D1 0.3520670 0.1365555 2.578198 0.0099317 0.0104100 0.0099317 0.0094586 1.422004e+00 1.0880893 1.858390e+00 Map6d1 up
69 MGAT4C MGAT4C -1.3821722 0.5241332 -2.637063 0.0083627 0.0040005 0.0083627 0.0095399 2.510327e-01 0.0898643 7.012506e-01 Mgat4c up
106 SLAIN2 SLAIN2 0.8455718 0.3292619 2.568083 0.0102263 0.0111327 0.0102263 0.0096223 2.329309e+00 1.2216841 4.441149e+00 Slain2 down
113 SPAG17 SPAG17 10.0872014 4.2371258 2.380671 0.0172812 0.0574988 0.0172812 0.0110288 2.403344e+04 5.9452191 9.715474e+07 Spag17 up
37 EFEMP1 EFEMP1 -0.2914440 0.1149583 -2.535214 0.0112379 0.0122232 0.0112379 0.0111204 7.471839e-01 0.5964510 9.360093e-01 Efemp1 up
12 CACNA2D2 CACNA2D2 -0.8043295 0.3205444 -2.509261 0.0120984 0.0098839 0.0120984 0.0118147 4.473878e-01 0.2386911 8.385559e-01 Cacna2d2 up
55 KLF14 KLF14 1.6071670 0.6370812 2.522703 0.0116457 0.0346226 0.0116457 0.0119965 4.988658e+00 1.4311964 1.738875e+01 Klf14 up
127 TTLL7 TTLL7 0.4510948 0.1808449 2.494374 0.0126179 0.0140847 0.0126179 0.0121624 1.570030e+00 1.1014697 2.237914e+00 Ttll7 up
28 CPA3 CPA3 -2.6676371 1.2839007 -2.077760 0.0377315 0.0010779 0.0377315 0.0122039 6.941610e-02 0.0056053 8.596431e-01 Cpa3 down
94 PRIMA1 PRIMA1 0.6222890 0.2488279 2.500881 0.0123885 0.0134312 0.0123885 0.0122378 1.863188e+00 1.1440737 3.034306e+00 Prima1 up
110 SLC7A11 SLC7A11 -0.5173928 0.2068672 -2.501087 0.0123813 0.0111473 0.0123813 0.0128561 5.960726e-01 0.3973869 8.940974e-01 Slc7a11 up
83 PDGFRA PDGFRA 0.3197732 0.1282574 2.493214 0.0126593 0.0114151 0.0126593 0.0129613 1.376815e+00 1.0707863 1.770307e+00 Pdgfra down
65 MAGEE2 MAGEE2 0.2072085 0.0847911 2.443752 0.0145354 0.0121291 0.0145354 0.0129998 1.230239e+00 1.0418739 1.452659e+00 Magee2 up
26 CLMN CLMN 0.5914685 0.2374123 2.491314 0.0127272 0.0186262 0.0127272 0.0131366 1.806639e+00 1.1344511 2.877115e+00 Clmn up
93 PPP2R2B PPP2R2B -0.7571162 0.3070699 -2.465615 0.0136778 0.0122080 0.0136778 0.0135049 4.690170e-01 0.2569273 8.561837e-01 Ppp2r2b up
70 MSR1 MSR1 0.6293928 0.2584362 2.435390 0.0148758 0.0257520 0.0148758 0.0144026 1.876471e+00 1.1307343 3.114032e+00 Msr1 down
16 CCL27 CCL27 -10.1807420 4.9394362 -2.061114 0.0392921 0.0011244 0.0392921 0.0147958 3.790000e-05 0.0000000 6.067582e-01 Ccl27a up
111 SLITRK5 SLITRK5 -0.4852339 0.1987193 -2.441806 0.0146140 0.0166802 0.0146140 0.0148097 6.155532e-01 0.4169802 9.086900e-01 Slitrk5 up
121 TFCP2L1 TFCP2L1 0.4640884 0.1932673 2.401277 0.0163379 0.0254705 0.0163379 0.0148488 1.590564e+00 1.0890344 2.323060e+00 Tfcp2l1 up
100 SCUBE3 SCUBE3 0.5114631 0.2125001 2.406884 0.0160893 0.0256815 0.0160893 0.0148709 1.667729e+00 1.0996264 2.529333e+00 Scube3 up
134 ZCCHC3 ZCCHC3 0.8449587 0.3501292 2.413277 0.0158098 0.0144719 0.0158098 0.0157013 2.327882e+00 1.1720075 4.623719e+00 Zcchc3 up
6 AHCYL2 AHCYL2 -0.4618186 0.1916865 -2.409239 0.0159858 0.0144949 0.0159858 0.0157534 6.301366e-01 0.4327837 9.174842e-01 Ahcyl2 up
84 PELI3 PELI3 -0.5361502 0.2219673 -2.415447 0.0157159 0.0125532 0.0157159 0.0158807 5.849960e-01 0.3786292 9.038405e-01 Peli3 up
117 SYT12 SYT12 -0.3974626 0.1658915 -2.395919 0.0165787 0.0103877 0.0165787 0.0161174 6.720231e-01 0.4854864 9.302320e-01 Syt12 up
61 LRRC6 LRRC6 -1.2100537 0.5083194 -2.380499 0.0172892 0.0148202 0.0172892 0.0162693 2.981813e-01 0.1101027 8.075373e-01 Lrrc6 up
77 OSR1 OSR1 0.2144682 0.0905432 2.368683 0.0178516 0.0251440 0.0178516 0.0166777 1.239203e+00 1.0377000 1.479834e+00 Osr1 up
90 PLK5 PLK5 -0.5414021 0.2291631 -2.362518 0.0181512 0.0166165 0.0181512 0.0175387 5.819318e-01 0.3713711 9.118766e-01 Plk5 up
59 LIX1 LIX1 -0.2840070 0.1205932 -2.355083 0.0185186 0.0237242 0.0185186 0.0177018 7.527614e-01 0.5943034 9.534687e-01 Lix1 up
45 GLRA3 GLRA3 -0.6180356 0.2634646 -2.345801 0.0189862 0.0133041 0.0189862 0.0185040 5.390022e-01 0.3216097 9.033416e-01 Glra3 up
71 NIPAL3 NIPAL3 0.3068599 0.1315510 2.332631 0.0196675 0.0202769 0.0196675 0.0189767 1.359150e+00 1.0502462 1.758911e+00 Nipal3 up
75 NSUN7 NSUN7 2.8988354 1.2476243 2.323484 0.0201532 0.0274793 0.0201532 0.0194083 1.815299e+01 1.5738687 2.093765e+02 Nsun7 up
3 ABLIM3 ABLIM3 -0.4204272 0.1804536 -2.329836 0.0198148 0.0196918 0.0198148 0.0196757 6.567662e-01 0.4611141 9.354340e-01 Ablim3 up
98 RNF32 RNF32 -0.7549155 0.3244026 -2.327095 0.0199602 0.0195812 0.0199602 0.0197767 4.700503e-01 0.2488928 8.877207e-01 Rnf32 up
30 CRYBB1 CRYBB1 -0.6109657 0.2598025 -2.351655 0.0186901 0.0162412 0.0186901 0.0199216 5.428264e-01 0.3262246 9.032443e-01 Crybb1 up
122 TNNI1 TNNI1 2.8923203 1.3335905 2.168822 0.0300962 0.0799377 0.0300962 0.0199732 1.803511e+01 1.3211876 2.461915e+02 Tnni1 up
91 POPDC3 POPDC3 0.3123546 0.1361879 2.293555 0.0218161 0.0284385 0.0218161 0.0201892 1.366639e+00 1.0464789 1.784749e+00 Popdc3 up
14 CAMSAP3 CAMSAP3 -0.2662145 0.1163447 -2.288152 0.0221286 0.0232764 0.0221286 0.0215514 7.662747e-01 0.6100307 9.625368e-01 Camsap3 up
42 FZD2 FZD2 0.3875964 0.1688566 2.295418 0.0217092 0.0214499 0.0217092 0.0216465 1.473435e+00 1.0582785 2.051455e+00 Fzd2 up
135 ZCCHC4 ZCCHC4 0.7571164 0.3109674 2.434713 0.0149036 0.0324878 0.0149036 0.0221649 2.132119e+00 1.1590857 3.921998e+00 Zcchc4 down
124 TPSB2 TPSB2 -0.4678065 0.2090684 -2.237576 0.0252487 0.0102559 0.0252487 0.0225107 6.263747e-01 0.4157908 9.436123e-01 Tpsb2 down
109 SLC4A4 SLC4A4 -0.4141597 0.1824616 -2.269846 0.0232169 0.0246088 0.0232169 0.0226269 6.608954e-01 0.4621906 9.450271e-01 Slc4a4 up
52 HTR2C HTR2C -3.1565775 1.3995778 -2.255378 0.0241096 0.0133067 0.0241096 0.0232918 4.257120e-02 0.0027403 6.613610e-01 Htr2c up
108 SLC35F4 SLC35F4 6.9660928 3.4145385 2.040127 0.0413377 0.1207829 0.0413377 0.0234941 1.060073e+03 1.3148471 8.546653e+05 Slc35f4 up
39 FAM111A FAM111A 0.4931808 0.2189509 2.252472 0.0242925 0.0261799 0.0242925 0.0238429 1.637517e+00 1.0661403 2.515110e+00 Fam111a down
118 SYT17 SYT17 -0.6691720 0.2974328 -2.249826 0.0244600 0.0230309 0.0244600 0.0240354 5.121324e-01 0.2858953 9.173975e-01 Syt17 up
95 PROK2 PROK2 1.8148931 0.8212733 2.209853 0.0271154 0.0412250 0.0271154 0.0258169 6.140420e+00 1.2278037 3.070911e+01 Prok2 up
136 ZNF519 ZNF519 0.7099944 0.3196717 2.221011 0.0263502 0.0282681 0.0263502 0.0258965 2.033980e+00 1.0870303 3.805850e+00 Zfp941 up
92 PPIL6 PPIL6 -0.8190445 0.3663250 -2.235841 0.0253622 0.0228182 0.0253622 0.0262949 4.408527e-01 0.2150191 9.038782e-01 Ppil6 up
67 MEIG1 MEIG1 -1.4153405 0.6416480 -2.205790 0.0273987 0.0165410 0.0273987 0.0263250 2.428429e-01 0.0690484 8.540773e-01 Meig1 up
41 FRY FRY -0.6736747 0.3074954 -2.190845 0.0284630 0.0283663 0.0284630 0.0281425 5.098316e-01 0.2790527 9.314667e-01 Fry up
24 CHST15 CHST15 -0.4167445 0.1902333 -2.190702 0.0284734 0.0278526 0.0284734 0.0281733 6.591893e-01 0.4540287 9.570553e-01 Chst15 up
19 CDH7 CDH7 -0.6616486 0.3054743 -2.165971 0.0303134 0.0216067 0.0303134 0.0286263 5.160000e-01 0.2835499 9.390093e-01 Cdh7 up
57 KNDC1 KNDC1 -0.2969632 0.1366881 -2.172560 0.0298134 0.0279141 0.0298134 0.0293196 7.430714e-01 0.5684358 9.713588e-01 Kndc1 up
125 TTC34 TTC34 -3.7733836 1.7457180 -2.161508 0.0306561 0.0235946 0.0306561 0.0297951 2.297420e-02 0.0007504 7.033933e-01 Ttc34 up
49 HHATL HHATL 0.2470745 0.1144943 2.157963 0.0309307 0.0303280 0.0309307 0.0308650 1.280274e+00 1.0229287 1.602363e+00 Hhatl up
53 KCNB1 KCNB1 -0.4829054 0.2251743 -2.144585 0.0319861 0.0281475 0.0319861 0.0316609 6.169882e-01 0.3968333 9.592804e-01 Kcnb1 up
51 HS6ST2 HS6ST2 0.8537621 0.4008883 2.129676 0.0331984 0.0357143 0.0331984 0.0317125 2.348466e+00 1.0704032 5.152535e+00 Hs6st2 up
126 TTLL11 TTLL11 1.3664702 0.6377193 2.142745 0.0321335 0.0412975 0.0321335 0.0321406 3.921484e+00 1.1236286 1.368605e+01 Ttll11 up
72 NLRP6 NLRP6 0.5442128 0.2548265 2.135621 0.0327103 0.0448962 0.0327103 0.0322133 1.723251e+00 1.0457789 2.839601e+00 Nlrp6 up
64 LUZP2 LUZP2 -0.3671389 0.1727341 -2.125457 0.0335485 0.0367364 0.0335485 0.0323780 6.927134e-01 0.4937670 9.718185e-01 Luzp2 up
10 BRINP1 BRINP1 -0.3392242 0.1600891 -2.118972 0.0340928 0.0305033 0.0340928 0.0324119 7.123227e-01 0.5204856 9.748658e-01 Brinp1 up
56 KLHDC9 KLHDC9 -0.2353128 0.1106619 -2.126413 0.0334689 0.0371299 0.0334689 0.0330566 7.903236e-01 0.6362230 9.817491e-01 Klhdc9 up
88 PLCB1 PLCB1 -0.6420079 0.3024846 -2.122448 0.0338001 0.0324093 0.0338001 0.0333069 5.262348e-01 0.2908735 9.520392e-01 Plcb1 up
105 SIDT1 SIDT1 -0.4174642 0.1983770 -2.104398 0.0353437 0.0278401 0.0353437 0.0339631 6.587150e-01 0.4465178 9.717541e-01 Sidt1 up
107 SLC1A2 SLC1A2 -0.2124443 0.1003561 -2.116904 0.0342680 0.0375824 0.0342680 0.0340428 8.086053e-01 0.6642221 9.843735e-01 Slc1a2 up
38 EMID1 EMID1 -0.4502308 0.2133506 -2.110287 0.0348337 0.0338802 0.0348337 0.0343860 6.374810e-01 0.4196265 9.684374e-01 Emid1 up
13 CACNA2D4 CACNA2D4 1.0245697 0.4891258 2.094696 0.0361980 0.0427101 0.0361980 0.0350024 2.785896e+00 1.0681207 7.266237e+00 Cacna2d4 up
76 NXPH3 NXPH3 -0.3774392 0.1806948 -2.088822 0.0367238 0.0409742 0.0367238 0.0363733 6.856149e-01 0.4811412 9.769850e-01 Nxph3 up
129 UNC13B UNC13B -0.7827685 0.3736143 -2.095125 0.0361599 0.0336327 0.0361599 0.0369294 4.571387e-01 0.2197996 9.507559e-01 Unc13b up
132 WNT9A WNT9A 0.6958626 0.3367280 2.066542 0.0387773 0.0463104 0.0387773 0.0378423 2.005438e+00 1.0365397 3.880008e+00 Wnt9a up
112 SMIM1 SMIM1 0.5206950 0.2527491 2.060126 0.0393865 0.0428917 0.0393865 0.0385225 1.683197e+00 1.0256390 2.762329e+00 Smim1 up
9 BAIAP3 BAIAP3 -0.2794113 0.1351514 -2.067396 0.0386969 0.0418946 0.0386969 0.0390339 7.562288e-01 0.5802460 9.855853e-01 Baiap3 up
33 DMKN DMKN -0.3291229 0.1606125 -2.049173 0.0404452 0.0368210 0.0404452 0.0393216 7.195546e-01 0.5252307 9.857741e-01 Dmkn up
115 SPRY3 SPRY3 0.4960903 0.2418322 2.051382 0.0402298 0.0386226 0.0402298 0.0404007 1.642288e+00 1.0223540 2.638136e+00 Spry3 up
2 ABHD3 ABHD3 0.5955091 0.2929307 2.032935 0.0420591 0.0407117 0.0420591 0.0409840 1.813954e+00 1.0216055 3.220842e+00 Abhd3 up
18 CD5L CD5L 0.7754014 0.3848963 2.014572 0.0439495 0.1129359 0.0439495 0.0414056 2.171464e+00 1.0212410 4.617181e+00 Cd5l down
58 LGI3 LGI3 0.1822722 0.0897599 2.030665 0.0422890 0.0443037 0.0422890 0.0414997 1.199941e+00 1.0063663 1.430749e+00 Lgi3 up
99 RSPO3 RSPO3 -0.6746499 0.3363098 -2.006037 0.0448523 0.0301619 0.0448523 0.0427121 5.093347e-01 0.2634728 9.846247e-01 Rspo3 up
32 DCHS2 DCHS2 -1.0486217 0.5210343 -2.012577 0.0441591 0.0349509 0.0441591 0.0427312 3.504204e-01 0.1262072 9.729591e-01 Dchs2 up
35 DNAH12 DNAH12 3.9025793 1.9420087 2.009558 0.0444780 0.0681526 0.0444780 0.0436603 4.953004e+01 1.1011029 2.227971e+03 Dnah12 up
31 CYB561 CYB561 -0.3508557 0.1754585 -1.999651 0.0455380 0.0350770 0.0455380 0.0445372 7.040854e-01 0.4992003 9.930608e-01 Cyb561 up
48 GPR176 GPR176 0.3455603 0.1729604 1.997916 0.0457257 0.0478815 0.0457257 0.0446132 1.412781e+00 1.0065858 1.982892e+00 Gpr176 up
34 DMRTC1 DMRTC1 98.5643120 49.8616264 1.976757 0.0480691 0.0630351 0.0480691 0.0448591 6.396418e+42 2.3101676 1.771047e+85 Dmrtc1a up
116 SPTBN5 SPTBN5 0.6025659 0.3021065 1.994548 0.0460922 0.0585582 0.0460922 0.0449381 1.826800e+00 1.0105029 3.302513e+00 Sptbn5 up
8 ARPP21 ARPP21 -0.3743726 0.1867061 -2.005144 0.0449477 0.0462126 0.0449477 0.0451881 6.877206e-01 0.4769661 9.916001e-01 Arpp21 up
7 ALDOC ALDOC -0.2765491 0.1381129 -2.002341 0.0452480 0.0542366 0.0452480 0.0455496 7.583964e-01 0.5785413 9.941643e-01 Aldoc up
23 CHST1 CHST1 -0.2144981 0.1081277 -1.983748 0.0472839 0.0521806 0.0472839 0.0467366 8.069463e-01 0.6528391 9.974316e-01 Chst1 up
131 WNT4 WNT4 -0.7042827 0.3598625 -1.957089 0.0503371 0.0247391 0.0503371 0.0469690 4.944631e-01 0.2442409 1.001035e+00 Wnt4 up
20 CDK6 CDK6 0.3824756 0.1938366 1.973185 0.0484744 0.0528413 0.0484744 0.0485995 1.465909e+00 1.0025661 2.143389e+00 Cdk6 down
97 RASGRF1 RASGRF1 -0.2693178 0.1370775 -1.964712 0.0494476 0.0439386 0.0494476 0.0487218 7.639004e-01 0.5839238 9.993493e-01 Rasgrf1 up
4 ADAMTS3 ADAMTS3 1.9769091 0.9586936 2.062086 0.0391995 0.0865033 0.0391995 0.0488657 7.220391e+00 1.1028571 4.727180e+01 Adamts3 up
119 SYT3 SYT3 -0.3410561 0.1739619 -1.960522 0.0499348 0.0391895 0.0499348 0.0489593 7.110190e-01 0.5055971 9.999029e-01 Syt3 up
81 PCDHGA4 PCDHGA4 1.0331251 0.5206786 1.984190 0.0472347 0.0638059 0.0472347 0.0497464 2.809833e+00 1.0126938 7.796199e+00 Pcdhga4 up
63 LSAMP LSAMP -0.6089189 0.3110885 -1.957382 0.0503026 0.0520013 0.0503026 0.0499826 5.439386e-01 0.2956316 1.000804e+00 Lsamp up

GBM_LGG

Gene-sets considered

UP and DOWN

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Table genes

Variable Term Beta StandardError Z P LRT Wald LogRank HR HRlower HRupper mm status
47 GPR139 GPR139 2.9954716 0.5459944 5.486268 0.0000000 0.0000008 0.0000000 0.0000000 1.999479e+01 6.8574946 5.829993e+01 Gpr139 up
11 BVES BVES 0.7842063 0.1424517 5.505070 0.0000000 0.0000025 0.0000000 0.0000001 2.190667e+00 1.6569958 2.896220e+00 Bves up
22 CHIC2 CHIC2 1.1744777 0.2267115 5.180495 0.0000002 0.0000079 0.0000002 0.0000002 3.236452e+00 2.0753531 5.047152e+00 Chic2 down
62 LRRK2 LRRK2 0.6724442 0.1341983 5.010825 0.0000005 0.0000059 0.0000005 0.0000002 1.959020e+00 1.5059447 2.548406e+00 Lrrk2 up
21 CEP135 CEP135 1.1901584 0.2479228 4.800520 0.0000016 0.0000491 0.0000016 0.0000014 3.287602e+00 2.0223064 5.344554e+00 Cep135 down
133 ZBTB8B ZBTB8B 1.1045218 0.2349319 4.701455 0.0000026 0.0000192 0.0000026 0.0000022 3.017781e+00 1.9042034 4.782579e+00 Zbtb8b up
86 PI4K2B PI4K2B 1.0371524 0.2498474 4.151143 0.0000331 0.0015532 0.0000331 0.0000217 2.821172e+00 1.7288568 4.603626e+00 Pi4k2b down
102 SERINC2 SERINC2 0.6263722 0.1610620 3.889012 0.0001007 0.0002453 0.0001007 0.0000827 1.870811e+00 1.3643749 2.565230e+00 Serinc2 up
104 SH3GL2 SH3GL2 -0.7907620 0.2005988 -3.942008 0.0000808 0.0000695 0.0000808 0.0001115 4.534991e-01 0.3060740 6.719337e-01 Sh3gl2 up
15 CCDC87 CCDC87 -0.7788043 0.2036870 -3.823535 0.0001316 0.0001516 0.0001316 0.0001223 4.589545e-01 0.3078867 6.841452e-01 Ccdc87 up
80 PCDHGA3 PCDHGA3 0.6336887 0.1854916 3.416266 0.0006349 0.0047731 0.0006349 0.0001990 1.884549e+00 1.3101371 2.710805e+00 Pcdhga3 up
101 SEPSECS SEPSECS 1.0745060 0.2684215 4.003055 0.0000625 0.0004790 0.0000625 0.0002610 2.928546e+00 1.7304985 4.956017e+00 Sepsecs down
78 PAX5 PAX5 4.3732708 1.3013911 3.360458 0.0007781 0.0111408 0.0007781 0.0002911 7.930259e+01 6.1878707 1.016327e+03 Pax5 down
54 KCNG1 KCNG1 -0.5347163 0.1540201 -3.471731 0.0005171 0.0001938 0.0005171 0.0004520 5.858355e-01 0.4331851 7.922784e-01 Kcng1 up
85 PHKG1 PHKG1 -0.3998301 0.1165522 -3.430480 0.0006025 0.0009269 0.0006025 0.0004617 6.704339e-01 0.5335149 8.424913e-01 Phkg1 up
50 HHIP HHIP 0.5367070 0.1575686 3.406179 0.0006588 0.0014311 0.0006588 0.0005304 1.710365e+00 1.2559323 2.329225e+00 Hhip up
36 EFCAB6 EFCAB6 -7.0065194 2.0604116 -3.400543 0.0006725 0.0002490 0.0006725 0.0005886 9.060000e-04 0.0000160 5.139640e-02 Efcab6 up
68 METTL11B METTL11B 2.6216611 0.8373169 3.131026 0.0017420 0.0097680 0.0017420 0.0007621 1.375856e+01 2.6659224 7.100655e+01 Mettl11b up
89 PLCXD1 PLCXD1 0.6979770 0.2051305 3.402601 0.0006675 0.0009493 0.0006675 0.0007977 2.009683e+00 1.3443743 3.004242e+00 Plcxd1 up
25 CLEC18A CLEC18A 2.0090652 0.6175386 3.253344 0.0011406 0.0037224 0.0011406 0.0009366 7.456344e+00 2.2226761 2.501357e+01 Clec18a up
82 PCDHGA8 PCDHGA8 4.5064285 1.4663795 3.073167 0.0021180 0.0114419 0.0021180 0.0016940 9.059767e+01 5.1160230 1.604359e+03 Pcdhga8 up
79 PCDH7 PCDH7 -0.7147787 0.2368258 -3.018163 0.0025431 0.0019136 0.0025431 0.0024481 4.893004e-01 0.3076020 7.783268e-01 Pcdh7 up
17 CCNB2 CCNB2 0.3221457 0.1089420 2.957039 0.0031061 0.0046368 0.0031061 0.0027830 1.380086e+00 1.1147424 1.708589e+00 Ccnb2 down
1 ABCA8 ABCA8 0.4256288 0.1413422 3.011336 0.0026010 0.0059862 0.0026010 0.0030725 1.530552e+00 1.1602125 2.019105e+00 Abca8b up
43 GDF10 GDF10 -0.3061819 0.1055962 -2.899555 0.0037369 0.0022250 0.0037369 0.0032660 7.362527e-01 0.5986090 9.055460e-01 Gdf10 up
44 GJA1 GJA1 -0.4050831 0.1380017 -2.935349 0.0033317 0.0035724 0.0033317 0.0034714 6.669214e-01 0.5088706 8.740613e-01 Gja1 up
29 CRTAC1 CRTAC1 -0.5539521 0.1912721 -2.896147 0.0037778 0.0040257 0.0037778 0.0037843 5.746742e-01 0.3950123 8.360510e-01 Crtac1 up
74 NRG3 NRG3 -2.4032161 0.8375289 -2.869413 0.0041123 0.0031459 0.0041123 0.0039243 9.042670e-02 0.0175142 4.668770e-01 Nrg3 up
123 TPSAB1 TPSAB1 -0.7426437 0.2748043 -2.702446 0.0068831 0.0004653 0.0068831 0.0039419 4.758542e-01 0.2776899 8.154320e-01 Tpsb2 down
128 TUB TUB -0.5196510 0.1808249 -2.873780 0.0040559 0.0047320 0.0040559 0.0041056 5.947281e-01 0.4172535 8.476897e-01 Tub up
103 SFTPC SFTPC 0.4223342 0.1487355 2.839498 0.0045185 0.0058762 0.0045185 0.0041667 1.525518e+00 1.1397603 2.041838e+00 Sftpc up
120 TCHH TCHH -0.5988549 0.2142769 -2.794771 0.0051936 0.0025865 0.0051936 0.0050215 5.494404e-01 0.3610171 8.362064e-01 Tchh up
130 VWC2 VWC2 -0.8118496 0.2985573 -2.719242 0.0065432 0.0042834 0.0065432 0.0057806 4.440360e-01 0.2473351 7.971695e-01 Vwc2 up
27 CNGA4 CNGA4 -1.0359853 0.3821171 -2.711172 0.0067046 0.0040296 0.0067046 0.0063590 3.548765e-01 0.1678103 7.504746e-01 Cnga4 up
114 SPHKAP SPHKAP -0.4625777 0.1721975 -2.686321 0.0072244 0.0065275 0.0072244 0.0068047 6.296585e-01 0.4492936 8.824291e-01 Sphkap up
46 GLT8D2 GLT8D2 -1.6440659 0.6170412 -2.664435 0.0077118 0.0045787 0.0077118 0.0071151 1.931929e-01 0.0576454 6.474670e-01 Glt8d2 up
40 FAM186B FAM186B 2.7648858 1.0270985 2.691938 0.0071038 0.0102688 0.0071038 0.0071928 1.587723e+01 2.1208349 1.188618e+02 Fam186b up
5 ADCY2 ADCY2 -0.5091532 0.1915128 -2.658586 0.0078469 0.0086014 0.0078469 0.0075234 6.010043e-01 0.4129159 8.747693e-01 Adcy2 up
87 PLA2G4E PLA2G4E 19.0823473 7.2463960 2.633357 0.0084545 0.0379296 0.0084545 0.0081310 1.938019e+08 131.5875091 2.854313e+14 Pla2g4e up
96 RAB42 RAB42 0.5038644 0.1915025 2.631111 0.0085106 0.0086515 0.0085106 0.0084776 1.655105e+00 1.1371513 2.408978e+00 Rab42 up
73 NR3C2 NR3C2 -1.1889369 0.4523989 -2.628072 0.0085870 0.0066070 0.0085870 0.0085969 3.045449e-01 0.1254783 7.391523e-01 Nr3c2 up
60 LRRC18 LRRC18 0.8248612 0.3172093 2.600369 0.0093124 0.0202333 0.0093124 0.0094480 2.281564e+00 1.2252469 4.248560e+00 Lrrc18 up
66 MAP6D1 MAP6D1 0.3520670 0.1365555 2.578198 0.0099317 0.0104100 0.0099317 0.0094586 1.422004e+00 1.0880893 1.858390e+00 Map6d1 up
69 MGAT4C MGAT4C -1.3821722 0.5241332 -2.637063 0.0083627 0.0040005 0.0083627 0.0095399 2.510327e-01 0.0898643 7.012506e-01 Mgat4c up
106 SLAIN2 SLAIN2 0.8455718 0.3292619 2.568083 0.0102263 0.0111327 0.0102263 0.0096223 2.329309e+00 1.2216841 4.441149e+00 Slain2 down
113 SPAG17 SPAG17 10.0872014 4.2371258 2.380671 0.0172812 0.0574988 0.0172812 0.0110288 2.403344e+04 5.9452191 9.715474e+07 Spag17 up
37 EFEMP1 EFEMP1 -0.2914440 0.1149583 -2.535214 0.0112379 0.0122232 0.0112379 0.0111204 7.471839e-01 0.5964510 9.360093e-01 Efemp1 up
12 CACNA2D2 CACNA2D2 -0.8043295 0.3205444 -2.509261 0.0120984 0.0098839 0.0120984 0.0118147 4.473878e-01 0.2386911 8.385559e-01 Cacna2d2 up
55 KLF14 KLF14 1.6071670 0.6370812 2.522703 0.0116457 0.0346226 0.0116457 0.0119965 4.988658e+00 1.4311964 1.738875e+01 Klf14 up
127 TTLL7 TTLL7 0.4510948 0.1808449 2.494374 0.0126179 0.0140847 0.0126179 0.0121624 1.570030e+00 1.1014697 2.237914e+00 Ttll7 up
28 CPA3 CPA3 -2.6676371 1.2839007 -2.077760 0.0377315 0.0010779 0.0377315 0.0122039 6.941610e-02 0.0056053 8.596431e-01 Cpa3 down
94 PRIMA1 PRIMA1 0.6222890 0.2488279 2.500881 0.0123885 0.0134312 0.0123885 0.0122378 1.863188e+00 1.1440737 3.034306e+00 Prima1 up
110 SLC7A11 SLC7A11 -0.5173928 0.2068672 -2.501087 0.0123813 0.0111473 0.0123813 0.0128561 5.960726e-01 0.3973869 8.940974e-01 Slc7a11 up
83 PDGFRA PDGFRA 0.3197732 0.1282574 2.493214 0.0126593 0.0114151 0.0126593 0.0129613 1.376815e+00 1.0707863 1.770307e+00 Pdgfra down
65 MAGEE2 MAGEE2 0.2072085 0.0847911 2.443752 0.0145354 0.0121291 0.0145354 0.0129998 1.230239e+00 1.0418739 1.452659e+00 Magee2 up
26 CLMN CLMN 0.5914685 0.2374123 2.491314 0.0127272 0.0186262 0.0127272 0.0131366 1.806639e+00 1.1344511 2.877115e+00 Clmn up
93 PPP2R2B PPP2R2B -0.7571162 0.3070699 -2.465615 0.0136778 0.0122080 0.0136778 0.0135049 4.690170e-01 0.2569273 8.561837e-01 Ppp2r2b up
70 MSR1 MSR1 0.6293928 0.2584362 2.435390 0.0148758 0.0257520 0.0148758 0.0144026 1.876471e+00 1.1307343 3.114032e+00 Msr1 down
16 CCL27 CCL27 -10.1807420 4.9394362 -2.061114 0.0392921 0.0011244 0.0392921 0.0147958 3.790000e-05 0.0000000 6.067582e-01 Ccl27a up
111 SLITRK5 SLITRK5 -0.4852339 0.1987193 -2.441806 0.0146140 0.0166802 0.0146140 0.0148097 6.155532e-01 0.4169802 9.086900e-01 Slitrk5 up
121 TFCP2L1 TFCP2L1 0.4640884 0.1932673 2.401277 0.0163379 0.0254705 0.0163379 0.0148488 1.590564e+00 1.0890344 2.323060e+00 Tfcp2l1 up
100 SCUBE3 SCUBE3 0.5114631 0.2125001 2.406884 0.0160893 0.0256815 0.0160893 0.0148709 1.667729e+00 1.0996264 2.529333e+00 Scube3 up
134 ZCCHC3 ZCCHC3 0.8449587 0.3501292 2.413277 0.0158098 0.0144719 0.0158098 0.0157013 2.327882e+00 1.1720075 4.623719e+00 Zcchc3 up
6 AHCYL2 AHCYL2 -0.4618186 0.1916865 -2.409239 0.0159858 0.0144949 0.0159858 0.0157534 6.301366e-01 0.4327837 9.174842e-01 Ahcyl2 up
84 PELI3 PELI3 -0.5361502 0.2219673 -2.415447 0.0157159 0.0125532 0.0157159 0.0158807 5.849960e-01 0.3786292 9.038405e-01 Peli3 up
117 SYT12 SYT12 -0.3974626 0.1658915 -2.395919 0.0165787 0.0103877 0.0165787 0.0161174 6.720231e-01 0.4854864 9.302320e-01 Syt12 up
61 LRRC6 LRRC6 -1.2100537 0.5083194 -2.380499 0.0172892 0.0148202 0.0172892 0.0162693 2.981813e-01 0.1101027 8.075373e-01 Lrrc6 up
77 OSR1 OSR1 0.2144682 0.0905432 2.368683 0.0178516 0.0251440 0.0178516 0.0166777 1.239203e+00 1.0377000 1.479834e+00 Osr1 up
90 PLK5 PLK5 -0.5414021 0.2291631 -2.362518 0.0181512 0.0166165 0.0181512 0.0175387 5.819318e-01 0.3713711 9.118766e-01 Plk5 up
59 LIX1 LIX1 -0.2840070 0.1205932 -2.355083 0.0185186 0.0237242 0.0185186 0.0177018 7.527614e-01 0.5943034 9.534687e-01 Lix1 up
45 GLRA3 GLRA3 -0.6180356 0.2634646 -2.345801 0.0189862 0.0133041 0.0189862 0.0185040 5.390022e-01 0.3216097 9.033416e-01 Glra3 up
71 NIPAL3 NIPAL3 0.3068599 0.1315510 2.332631 0.0196675 0.0202769 0.0196675 0.0189767 1.359150e+00 1.0502462 1.758911e+00 Nipal3 up
75 NSUN7 NSUN7 2.8988354 1.2476243 2.323484 0.0201532 0.0274793 0.0201532 0.0194083 1.815299e+01 1.5738687 2.093765e+02 Nsun7 up
3 ABLIM3 ABLIM3 -0.4204272 0.1804536 -2.329836 0.0198148 0.0196918 0.0198148 0.0196757 6.567662e-01 0.4611141 9.354340e-01 Ablim3 up
98 RNF32 RNF32 -0.7549155 0.3244026 -2.327095 0.0199602 0.0195812 0.0199602 0.0197767 4.700503e-01 0.2488928 8.877207e-01 Rnf32 up
30 CRYBB1 CRYBB1 -0.6109657 0.2598025 -2.351655 0.0186901 0.0162412 0.0186901 0.0199216 5.428264e-01 0.3262246 9.032443e-01 Crybb1 up
122 TNNI1 TNNI1 2.8923203 1.3335905 2.168822 0.0300962 0.0799377 0.0300962 0.0199732 1.803511e+01 1.3211876 2.461915e+02 Tnni1 up
91 POPDC3 POPDC3 0.3123546 0.1361879 2.293555 0.0218161 0.0284385 0.0218161 0.0201892 1.366639e+00 1.0464789 1.784749e+00 Popdc3 up
14 CAMSAP3 CAMSAP3 -0.2662145 0.1163447 -2.288152 0.0221286 0.0232764 0.0221286 0.0215514 7.662747e-01 0.6100307 9.625368e-01 Camsap3 up
42 FZD2 FZD2 0.3875964 0.1688566 2.295418 0.0217092 0.0214499 0.0217092 0.0216465 1.473435e+00 1.0582785 2.051455e+00 Fzd2 up
135 ZCCHC4 ZCCHC4 0.7571164 0.3109674 2.434713 0.0149036 0.0324878 0.0149036 0.0221649 2.132119e+00 1.1590857 3.921998e+00 Zcchc4 down
124 TPSB2 TPSB2 -0.4678065 0.2090684 -2.237576 0.0252487 0.0102559 0.0252487 0.0225107 6.263747e-01 0.4157908 9.436123e-01 Tpsb2 down
109 SLC4A4 SLC4A4 -0.4141597 0.1824616 -2.269846 0.0232169 0.0246088 0.0232169 0.0226269 6.608954e-01 0.4621906 9.450271e-01 Slc4a4 up
52 HTR2C HTR2C -3.1565775 1.3995778 -2.255378 0.0241096 0.0133067 0.0241096 0.0232918 4.257120e-02 0.0027403 6.613610e-01 Htr2c up
108 SLC35F4 SLC35F4 6.9660928 3.4145385 2.040127 0.0413377 0.1207829 0.0413377 0.0234941 1.060073e+03 1.3148471 8.546653e+05 Slc35f4 up
39 FAM111A FAM111A 0.4931808 0.2189509 2.252472 0.0242925 0.0261799 0.0242925 0.0238429 1.637517e+00 1.0661403 2.515110e+00 Fam111a down
118 SYT17 SYT17 -0.6691720 0.2974328 -2.249826 0.0244600 0.0230309 0.0244600 0.0240354 5.121324e-01 0.2858953 9.173975e-01 Syt17 up
95 PROK2 PROK2 1.8148931 0.8212733 2.209853 0.0271154 0.0412250 0.0271154 0.0258169 6.140420e+00 1.2278037 3.070911e+01 Prok2 up
136 ZNF519 ZNF519 0.7099944 0.3196717 2.221011 0.0263502 0.0282681 0.0263502 0.0258965 2.033980e+00 1.0870303 3.805850e+00 Zfp941 up
92 PPIL6 PPIL6 -0.8190445 0.3663250 -2.235841 0.0253622 0.0228182 0.0253622 0.0262949 4.408527e-01 0.2150191 9.038782e-01 Ppil6 up
67 MEIG1 MEIG1 -1.4153405 0.6416480 -2.205790 0.0273987 0.0165410 0.0273987 0.0263250 2.428429e-01 0.0690484 8.540773e-01 Meig1 up
41 FRY FRY -0.6736747 0.3074954 -2.190845 0.0284630 0.0283663 0.0284630 0.0281425 5.098316e-01 0.2790527 9.314667e-01 Fry up
24 CHST15 CHST15 -0.4167445 0.1902333 -2.190702 0.0284734 0.0278526 0.0284734 0.0281733 6.591893e-01 0.4540287 9.570553e-01 Chst15 up
19 CDH7 CDH7 -0.6616486 0.3054743 -2.165971 0.0303134 0.0216067 0.0303134 0.0286263 5.160000e-01 0.2835499 9.390093e-01 Cdh7 up
57 KNDC1 KNDC1 -0.2969632 0.1366881 -2.172560 0.0298134 0.0279141 0.0298134 0.0293196 7.430714e-01 0.5684358 9.713588e-01 Kndc1 up
125 TTC34 TTC34 -3.7733836 1.7457180 -2.161508 0.0306561 0.0235946 0.0306561 0.0297951 2.297420e-02 0.0007504 7.033933e-01 Ttc34 up
49 HHATL HHATL 0.2470745 0.1144943 2.157963 0.0309307 0.0303280 0.0309307 0.0308650 1.280274e+00 1.0229287 1.602363e+00 Hhatl up
53 KCNB1 KCNB1 -0.4829054 0.2251743 -2.144585 0.0319861 0.0281475 0.0319861 0.0316609 6.169882e-01 0.3968333 9.592804e-01 Kcnb1 up
51 HS6ST2 HS6ST2 0.8537621 0.4008883 2.129676 0.0331984 0.0357143 0.0331984 0.0317125 2.348466e+00 1.0704032 5.152535e+00 Hs6st2 up
126 TTLL11 TTLL11 1.3664702 0.6377193 2.142745 0.0321335 0.0412975 0.0321335 0.0321406 3.921484e+00 1.1236286 1.368605e+01 Ttll11 up
72 NLRP6 NLRP6 0.5442128 0.2548265 2.135621 0.0327103 0.0448962 0.0327103 0.0322133 1.723251e+00 1.0457789 2.839601e+00 Nlrp6 up
64 LUZP2 LUZP2 -0.3671389 0.1727341 -2.125457 0.0335485 0.0367364 0.0335485 0.0323780 6.927134e-01 0.4937670 9.718185e-01 Luzp2 up
10 BRINP1 BRINP1 -0.3392242 0.1600891 -2.118972 0.0340928 0.0305033 0.0340928 0.0324119 7.123227e-01 0.5204856 9.748658e-01 Brinp1 up
56 KLHDC9 KLHDC9 -0.2353128 0.1106619 -2.126413 0.0334689 0.0371299 0.0334689 0.0330566 7.903236e-01 0.6362230 9.817491e-01 Klhdc9 up
88 PLCB1 PLCB1 -0.6420079 0.3024846 -2.122448 0.0338001 0.0324093 0.0338001 0.0333069 5.262348e-01 0.2908735 9.520392e-01 Plcb1 up
105 SIDT1 SIDT1 -0.4174642 0.1983770 -2.104398 0.0353437 0.0278401 0.0353437 0.0339631 6.587150e-01 0.4465178 9.717541e-01 Sidt1 up
107 SLC1A2 SLC1A2 -0.2124443 0.1003561 -2.116904 0.0342680 0.0375824 0.0342680 0.0340428 8.086053e-01 0.6642221 9.843735e-01 Slc1a2 up
38 EMID1 EMID1 -0.4502308 0.2133506 -2.110287 0.0348337 0.0338802 0.0348337 0.0343860 6.374810e-01 0.4196265 9.684374e-01 Emid1 up
13 CACNA2D4 CACNA2D4 1.0245697 0.4891258 2.094696 0.0361980 0.0427101 0.0361980 0.0350024 2.785896e+00 1.0681207 7.266237e+00 Cacna2d4 up
76 NXPH3 NXPH3 -0.3774392 0.1806948 -2.088822 0.0367238 0.0409742 0.0367238 0.0363733 6.856149e-01 0.4811412 9.769850e-01 Nxph3 up
129 UNC13B UNC13B -0.7827685 0.3736143 -2.095125 0.0361599 0.0336327 0.0361599 0.0369294 4.571387e-01 0.2197996 9.507559e-01 Unc13b up
132 WNT9A WNT9A 0.6958626 0.3367280 2.066542 0.0387773 0.0463104 0.0387773 0.0378423 2.005438e+00 1.0365397 3.880008e+00 Wnt9a up
112 SMIM1 SMIM1 0.5206950 0.2527491 2.060126 0.0393865 0.0428917 0.0393865 0.0385225 1.683197e+00 1.0256390 2.762329e+00 Smim1 up
9 BAIAP3 BAIAP3 -0.2794113 0.1351514 -2.067396 0.0386969 0.0418946 0.0386969 0.0390339 7.562288e-01 0.5802460 9.855853e-01 Baiap3 up
33 DMKN DMKN -0.3291229 0.1606125 -2.049173 0.0404452 0.0368210 0.0404452 0.0393216 7.195546e-01 0.5252307 9.857741e-01 Dmkn up
115 SPRY3 SPRY3 0.4960903 0.2418322 2.051382 0.0402298 0.0386226 0.0402298 0.0404007 1.642288e+00 1.0223540 2.638136e+00 Spry3 up
2 ABHD3 ABHD3 0.5955091 0.2929307 2.032935 0.0420591 0.0407117 0.0420591 0.0409840 1.813954e+00 1.0216055 3.220842e+00 Abhd3 up
18 CD5L CD5L 0.7754014 0.3848963 2.014572 0.0439495 0.1129359 0.0439495 0.0414056 2.171464e+00 1.0212410 4.617181e+00 Cd5l down
58 LGI3 LGI3 0.1822722 0.0897599 2.030665 0.0422890 0.0443037 0.0422890 0.0414997 1.199941e+00 1.0063663 1.430749e+00 Lgi3 up
99 RSPO3 RSPO3 -0.6746499 0.3363098 -2.006037 0.0448523 0.0301619 0.0448523 0.0427121 5.093347e-01 0.2634728 9.846247e-01 Rspo3 up
32 DCHS2 DCHS2 -1.0486217 0.5210343 -2.012577 0.0441591 0.0349509 0.0441591 0.0427312 3.504204e-01 0.1262072 9.729591e-01 Dchs2 up
35 DNAH12 DNAH12 3.9025793 1.9420087 2.009558 0.0444780 0.0681526 0.0444780 0.0436603 4.953004e+01 1.1011029 2.227971e+03 Dnah12 up
31 CYB561 CYB561 -0.3508557 0.1754585 -1.999651 0.0455380 0.0350770 0.0455380 0.0445372 7.040854e-01 0.4992003 9.930608e-01 Cyb561 up
48 GPR176 GPR176 0.3455603 0.1729604 1.997916 0.0457257 0.0478815 0.0457257 0.0446132 1.412781e+00 1.0065858 1.982892e+00 Gpr176 up
34 DMRTC1 DMRTC1 98.5643120 49.8616264 1.976757 0.0480691 0.0630351 0.0480691 0.0448591 6.396418e+42 2.3101676 1.771047e+85 Dmrtc1a up
116 SPTBN5 SPTBN5 0.6025659 0.3021065 1.994548 0.0460922 0.0585582 0.0460922 0.0449381 1.826800e+00 1.0105029 3.302513e+00 Sptbn5 up
8 ARPP21 ARPP21 -0.3743726 0.1867061 -2.005144 0.0449477 0.0462126 0.0449477 0.0451881 6.877206e-01 0.4769661 9.916001e-01 Arpp21 up
7 ALDOC ALDOC -0.2765491 0.1381129 -2.002341 0.0452480 0.0542366 0.0452480 0.0455496 7.583964e-01 0.5785413 9.941643e-01 Aldoc up
23 CHST1 CHST1 -0.2144981 0.1081277 -1.983748 0.0472839 0.0521806 0.0472839 0.0467366 8.069463e-01 0.6528391 9.974316e-01 Chst1 up
131 WNT4 WNT4 -0.7042827 0.3598625 -1.957089 0.0503371 0.0247391 0.0503371 0.0469690 4.944631e-01 0.2442409 1.001035e+00 Wnt4 up
20 CDK6 CDK6 0.3824756 0.1938366 1.973185 0.0484744 0.0528413 0.0484744 0.0485995 1.465909e+00 1.0025661 2.143389e+00 Cdk6 down
97 RASGRF1 RASGRF1 -0.2693178 0.1370775 -1.964712 0.0494476 0.0439386 0.0494476 0.0487218 7.639004e-01 0.5839238 9.993493e-01 Rasgrf1 up
4 ADAMTS3 ADAMTS3 1.9769091 0.9586936 2.062086 0.0391995 0.0865033 0.0391995 0.0488657 7.220391e+00 1.1028571 4.727180e+01 Adamts3 up
119 SYT3 SYT3 -0.3410561 0.1739619 -1.960522 0.0499348 0.0391895 0.0499348 0.0489593 7.110190e-01 0.5055971 9.999029e-01 Syt3 up
81 PCDHGA4 PCDHGA4 1.0331251 0.5206786 1.984190 0.0472347 0.0638059 0.0472347 0.0497464 2.809833e+00 1.0126938 7.796199e+00 Pcdhga4 up
63 LSAMP LSAMP -0.6089189 0.3110885 -1.957382 0.0503026 0.0520013 0.0503026 0.0499826 5.439386e-01 0.2956316 1.000804e+00 Lsamp up

only GBM

Gene-sets considered

UP and DOWN

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Table genes

Variable Term Beta StandardError Z P LRT Wald LogRank HR HRlower HRupper mm status
47 GPR139 GPR139 2.9954716 0.5459944 5.486268 0.0000000 0.0000008 0.0000000 0.0000000 1.999479e+01 6.8574946 5.829993e+01 Gpr139 up
11 BVES BVES 0.7842063 0.1424517 5.505070 0.0000000 0.0000025 0.0000000 0.0000001 2.190667e+00 1.6569958 2.896220e+00 Bves up
22 CHIC2 CHIC2 1.1744777 0.2267115 5.180495 0.0000002 0.0000079 0.0000002 0.0000002 3.236452e+00 2.0753531 5.047152e+00 Chic2 down
62 LRRK2 LRRK2 0.6724442 0.1341983 5.010825 0.0000005 0.0000059 0.0000005 0.0000002 1.959020e+00 1.5059447 2.548406e+00 Lrrk2 up
21 CEP135 CEP135 1.1901584 0.2479228 4.800520 0.0000016 0.0000491 0.0000016 0.0000014 3.287602e+00 2.0223064 5.344554e+00 Cep135 down
133 ZBTB8B ZBTB8B 1.1045218 0.2349319 4.701455 0.0000026 0.0000192 0.0000026 0.0000022 3.017781e+00 1.9042034 4.782579e+00 Zbtb8b up
86 PI4K2B PI4K2B 1.0371524 0.2498474 4.151143 0.0000331 0.0015532 0.0000331 0.0000217 2.821172e+00 1.7288568 4.603626e+00 Pi4k2b down
102 SERINC2 SERINC2 0.6263722 0.1610620 3.889012 0.0001007 0.0002453 0.0001007 0.0000827 1.870811e+00 1.3643749 2.565230e+00 Serinc2 up
104 SH3GL2 SH3GL2 -0.7907620 0.2005988 -3.942008 0.0000808 0.0000695 0.0000808 0.0001115 4.534991e-01 0.3060740 6.719337e-01 Sh3gl2 up
15 CCDC87 CCDC87 -0.7788043 0.2036870 -3.823535 0.0001316 0.0001516 0.0001316 0.0001223 4.589545e-01 0.3078867 6.841452e-01 Ccdc87 up
80 PCDHGA3 PCDHGA3 0.6336887 0.1854916 3.416266 0.0006349 0.0047731 0.0006349 0.0001990 1.884549e+00 1.3101371 2.710805e+00 Pcdhga3 up
101 SEPSECS SEPSECS 1.0745060 0.2684215 4.003055 0.0000625 0.0004790 0.0000625 0.0002610 2.928546e+00 1.7304985 4.956017e+00 Sepsecs down
78 PAX5 PAX5 4.3732708 1.3013911 3.360458 0.0007781 0.0111408 0.0007781 0.0002911 7.930259e+01 6.1878707 1.016327e+03 Pax5 down
54 KCNG1 KCNG1 -0.5347163 0.1540201 -3.471731 0.0005171 0.0001938 0.0005171 0.0004520 5.858355e-01 0.4331851 7.922784e-01 Kcng1 up
85 PHKG1 PHKG1 -0.3998301 0.1165522 -3.430480 0.0006025 0.0009269 0.0006025 0.0004617 6.704339e-01 0.5335149 8.424913e-01 Phkg1 up
50 HHIP HHIP 0.5367070 0.1575686 3.406179 0.0006588 0.0014311 0.0006588 0.0005304 1.710365e+00 1.2559323 2.329225e+00 Hhip up
36 EFCAB6 EFCAB6 -7.0065194 2.0604116 -3.400543 0.0006725 0.0002490 0.0006725 0.0005886 9.060000e-04 0.0000160 5.139640e-02 Efcab6 up
68 METTL11B METTL11B 2.6216611 0.8373169 3.131026 0.0017420 0.0097680 0.0017420 0.0007621 1.375856e+01 2.6659224 7.100655e+01 Mettl11b up
89 PLCXD1 PLCXD1 0.6979770 0.2051305 3.402601 0.0006675 0.0009493 0.0006675 0.0007977 2.009683e+00 1.3443743 3.004242e+00 Plcxd1 up
25 CLEC18A CLEC18A 2.0090652 0.6175386 3.253344 0.0011406 0.0037224 0.0011406 0.0009366 7.456344e+00 2.2226761 2.501357e+01 Clec18a up
82 PCDHGA8 PCDHGA8 4.5064285 1.4663795 3.073167 0.0021180 0.0114419 0.0021180 0.0016940 9.059767e+01 5.1160230 1.604359e+03 Pcdhga8 up
79 PCDH7 PCDH7 -0.7147787 0.2368258 -3.018163 0.0025431 0.0019136 0.0025431 0.0024481 4.893004e-01 0.3076020 7.783268e-01 Pcdh7 up
17 CCNB2 CCNB2 0.3221457 0.1089420 2.957039 0.0031061 0.0046368 0.0031061 0.0027830 1.380086e+00 1.1147424 1.708589e+00 Ccnb2 down
1 ABCA8 ABCA8 0.4256288 0.1413422 3.011336 0.0026010 0.0059862 0.0026010 0.0030725 1.530552e+00 1.1602125 2.019105e+00 Abca8b up
43 GDF10 GDF10 -0.3061819 0.1055962 -2.899555 0.0037369 0.0022250 0.0037369 0.0032660 7.362527e-01 0.5986090 9.055460e-01 Gdf10 up
44 GJA1 GJA1 -0.4050831 0.1380017 -2.935349 0.0033317 0.0035724 0.0033317 0.0034714 6.669214e-01 0.5088706 8.740613e-01 Gja1 up
29 CRTAC1 CRTAC1 -0.5539521 0.1912721 -2.896147 0.0037778 0.0040257 0.0037778 0.0037843 5.746742e-01 0.3950123 8.360510e-01 Crtac1 up
74 NRG3 NRG3 -2.4032161 0.8375289 -2.869413 0.0041123 0.0031459 0.0041123 0.0039243 9.042670e-02 0.0175142 4.668770e-01 Nrg3 up
123 TPSAB1 TPSAB1 -0.7426437 0.2748043 -2.702446 0.0068831 0.0004653 0.0068831 0.0039419 4.758542e-01 0.2776899 8.154320e-01 Tpsb2 down
128 TUB TUB -0.5196510 0.1808249 -2.873780 0.0040559 0.0047320 0.0040559 0.0041056 5.947281e-01 0.4172535 8.476897e-01 Tub up
103 SFTPC SFTPC 0.4223342 0.1487355 2.839498 0.0045185 0.0058762 0.0045185 0.0041667 1.525518e+00 1.1397603 2.041838e+00 Sftpc up
120 TCHH TCHH -0.5988549 0.2142769 -2.794771 0.0051936 0.0025865 0.0051936 0.0050215 5.494404e-01 0.3610171 8.362064e-01 Tchh up
130 VWC2 VWC2 -0.8118496 0.2985573 -2.719242 0.0065432 0.0042834 0.0065432 0.0057806 4.440360e-01 0.2473351 7.971695e-01 Vwc2 up
27 CNGA4 CNGA4 -1.0359853 0.3821171 -2.711172 0.0067046 0.0040296 0.0067046 0.0063590 3.548765e-01 0.1678103 7.504746e-01 Cnga4 up
114 SPHKAP SPHKAP -0.4625777 0.1721975 -2.686321 0.0072244 0.0065275 0.0072244 0.0068047 6.296585e-01 0.4492936 8.824291e-01 Sphkap up
46 GLT8D2 GLT8D2 -1.6440659 0.6170412 -2.664435 0.0077118 0.0045787 0.0077118 0.0071151 1.931929e-01 0.0576454 6.474670e-01 Glt8d2 up
40 FAM186B FAM186B 2.7648858 1.0270985 2.691938 0.0071038 0.0102688 0.0071038 0.0071928 1.587723e+01 2.1208349 1.188618e+02 Fam186b up
5 ADCY2 ADCY2 -0.5091532 0.1915128 -2.658586 0.0078469 0.0086014 0.0078469 0.0075234 6.010043e-01 0.4129159 8.747693e-01 Adcy2 up
87 PLA2G4E PLA2G4E 19.0823473 7.2463960 2.633357 0.0084545 0.0379296 0.0084545 0.0081310 1.938019e+08 131.5875091 2.854313e+14 Pla2g4e up
96 RAB42 RAB42 0.5038644 0.1915025 2.631111 0.0085106 0.0086515 0.0085106 0.0084776 1.655105e+00 1.1371513 2.408978e+00 Rab42 up
73 NR3C2 NR3C2 -1.1889369 0.4523989 -2.628072 0.0085870 0.0066070 0.0085870 0.0085969 3.045449e-01 0.1254783 7.391523e-01 Nr3c2 up
60 LRRC18 LRRC18 0.8248612 0.3172093 2.600369 0.0093124 0.0202333 0.0093124 0.0094480 2.281564e+00 1.2252469 4.248560e+00 Lrrc18 up
66 MAP6D1 MAP6D1 0.3520670 0.1365555 2.578198 0.0099317 0.0104100 0.0099317 0.0094586 1.422004e+00 1.0880893 1.858390e+00 Map6d1 up
69 MGAT4C MGAT4C -1.3821722 0.5241332 -2.637063 0.0083627 0.0040005 0.0083627 0.0095399 2.510327e-01 0.0898643 7.012506e-01 Mgat4c up
106 SLAIN2 SLAIN2 0.8455718 0.3292619 2.568083 0.0102263 0.0111327 0.0102263 0.0096223 2.329309e+00 1.2216841 4.441149e+00 Slain2 down
113 SPAG17 SPAG17 10.0872014 4.2371258 2.380671 0.0172812 0.0574988 0.0172812 0.0110288 2.403344e+04 5.9452191 9.715474e+07 Spag17 up
37 EFEMP1 EFEMP1 -0.2914440 0.1149583 -2.535214 0.0112379 0.0122232 0.0112379 0.0111204 7.471839e-01 0.5964510 9.360093e-01 Efemp1 up
12 CACNA2D2 CACNA2D2 -0.8043295 0.3205444 -2.509261 0.0120984 0.0098839 0.0120984 0.0118147 4.473878e-01 0.2386911 8.385559e-01 Cacna2d2 up
55 KLF14 KLF14 1.6071670 0.6370812 2.522703 0.0116457 0.0346226 0.0116457 0.0119965 4.988658e+00 1.4311964 1.738875e+01 Klf14 up
127 TTLL7 TTLL7 0.4510948 0.1808449 2.494374 0.0126179 0.0140847 0.0126179 0.0121624 1.570030e+00 1.1014697 2.237914e+00 Ttll7 up
28 CPA3 CPA3 -2.6676371 1.2839007 -2.077760 0.0377315 0.0010779 0.0377315 0.0122039 6.941610e-02 0.0056053 8.596431e-01 Cpa3 down
94 PRIMA1 PRIMA1 0.6222890 0.2488279 2.500881 0.0123885 0.0134312 0.0123885 0.0122378 1.863188e+00 1.1440737 3.034306e+00 Prima1 up
110 SLC7A11 SLC7A11 -0.5173928 0.2068672 -2.501087 0.0123813 0.0111473 0.0123813 0.0128561 5.960726e-01 0.3973869 8.940974e-01 Slc7a11 up
83 PDGFRA PDGFRA 0.3197732 0.1282574 2.493214 0.0126593 0.0114151 0.0126593 0.0129613 1.376815e+00 1.0707863 1.770307e+00 Pdgfra down
65 MAGEE2 MAGEE2 0.2072085 0.0847911 2.443752 0.0145354 0.0121291 0.0145354 0.0129998 1.230239e+00 1.0418739 1.452659e+00 Magee2 up
26 CLMN CLMN 0.5914685 0.2374123 2.491314 0.0127272 0.0186262 0.0127272 0.0131366 1.806639e+00 1.1344511 2.877115e+00 Clmn up
93 PPP2R2B PPP2R2B -0.7571162 0.3070699 -2.465615 0.0136778 0.0122080 0.0136778 0.0135049 4.690170e-01 0.2569273 8.561837e-01 Ppp2r2b up
70 MSR1 MSR1 0.6293928 0.2584362 2.435390 0.0148758 0.0257520 0.0148758 0.0144026 1.876471e+00 1.1307343 3.114032e+00 Msr1 down
16 CCL27 CCL27 -10.1807420 4.9394362 -2.061114 0.0392921 0.0011244 0.0392921 0.0147958 3.790000e-05 0.0000000 6.067582e-01 Ccl27a up
111 SLITRK5 SLITRK5 -0.4852339 0.1987193 -2.441806 0.0146140 0.0166802 0.0146140 0.0148097 6.155532e-01 0.4169802 9.086900e-01 Slitrk5 up
121 TFCP2L1 TFCP2L1 0.4640884 0.1932673 2.401277 0.0163379 0.0254705 0.0163379 0.0148488 1.590564e+00 1.0890344 2.323060e+00 Tfcp2l1 up
100 SCUBE3 SCUBE3 0.5114631 0.2125001 2.406884 0.0160893 0.0256815 0.0160893 0.0148709 1.667729e+00 1.0996264 2.529333e+00 Scube3 up
134 ZCCHC3 ZCCHC3 0.8449587 0.3501292 2.413277 0.0158098 0.0144719 0.0158098 0.0157013 2.327882e+00 1.1720075 4.623719e+00 Zcchc3 up
6 AHCYL2 AHCYL2 -0.4618186 0.1916865 -2.409239 0.0159858 0.0144949 0.0159858 0.0157534 6.301366e-01 0.4327837 9.174842e-01 Ahcyl2 up
84 PELI3 PELI3 -0.5361502 0.2219673 -2.415447 0.0157159 0.0125532 0.0157159 0.0158807 5.849960e-01 0.3786292 9.038405e-01 Peli3 up
117 SYT12 SYT12 -0.3974626 0.1658915 -2.395919 0.0165787 0.0103877 0.0165787 0.0161174 6.720231e-01 0.4854864 9.302320e-01 Syt12 up
61 LRRC6 LRRC6 -1.2100537 0.5083194 -2.380499 0.0172892 0.0148202 0.0172892 0.0162693 2.981813e-01 0.1101027 8.075373e-01 Lrrc6 up
77 OSR1 OSR1 0.2144682 0.0905432 2.368683 0.0178516 0.0251440 0.0178516 0.0166777 1.239203e+00 1.0377000 1.479834e+00 Osr1 up
90 PLK5 PLK5 -0.5414021 0.2291631 -2.362518 0.0181512 0.0166165 0.0181512 0.0175387 5.819318e-01 0.3713711 9.118766e-01 Plk5 up
59 LIX1 LIX1 -0.2840070 0.1205932 -2.355083 0.0185186 0.0237242 0.0185186 0.0177018 7.527614e-01 0.5943034 9.534687e-01 Lix1 up
45 GLRA3 GLRA3 -0.6180356 0.2634646 -2.345801 0.0189862 0.0133041 0.0189862 0.0185040 5.390022e-01 0.3216097 9.033416e-01 Glra3 up
71 NIPAL3 NIPAL3 0.3068599 0.1315510 2.332631 0.0196675 0.0202769 0.0196675 0.0189767 1.359150e+00 1.0502462 1.758911e+00 Nipal3 up
75 NSUN7 NSUN7 2.8988354 1.2476243 2.323484 0.0201532 0.0274793 0.0201532 0.0194083 1.815299e+01 1.5738687 2.093765e+02 Nsun7 up
3 ABLIM3 ABLIM3 -0.4204272 0.1804536 -2.329836 0.0198148 0.0196918 0.0198148 0.0196757 6.567662e-01 0.4611141 9.354340e-01 Ablim3 up
98 RNF32 RNF32 -0.7549155 0.3244026 -2.327095 0.0199602 0.0195812 0.0199602 0.0197767 4.700503e-01 0.2488928 8.877207e-01 Rnf32 up
30 CRYBB1 CRYBB1 -0.6109657 0.2598025 -2.351655 0.0186901 0.0162412 0.0186901 0.0199216 5.428264e-01 0.3262246 9.032443e-01 Crybb1 up
122 TNNI1 TNNI1 2.8923203 1.3335905 2.168822 0.0300962 0.0799377 0.0300962 0.0199732 1.803511e+01 1.3211876 2.461915e+02 Tnni1 up
91 POPDC3 POPDC3 0.3123546 0.1361879 2.293555 0.0218161 0.0284385 0.0218161 0.0201892 1.366639e+00 1.0464789 1.784749e+00 Popdc3 up
14 CAMSAP3 CAMSAP3 -0.2662145 0.1163447 -2.288152 0.0221286 0.0232764 0.0221286 0.0215514 7.662747e-01 0.6100307 9.625368e-01 Camsap3 up
42 FZD2 FZD2 0.3875964 0.1688566 2.295418 0.0217092 0.0214499 0.0217092 0.0216465 1.473435e+00 1.0582785 2.051455e+00 Fzd2 up
135 ZCCHC4 ZCCHC4 0.7571164 0.3109674 2.434713 0.0149036 0.0324878 0.0149036 0.0221649 2.132119e+00 1.1590857 3.921998e+00 Zcchc4 down
124 TPSB2 TPSB2 -0.4678065 0.2090684 -2.237576 0.0252487 0.0102559 0.0252487 0.0225107 6.263747e-01 0.4157908 9.436123e-01 Tpsb2 down
109 SLC4A4 SLC4A4 -0.4141597 0.1824616 -2.269846 0.0232169 0.0246088 0.0232169 0.0226269 6.608954e-01 0.4621906 9.450271e-01 Slc4a4 up
52 HTR2C HTR2C -3.1565775 1.3995778 -2.255378 0.0241096 0.0133067 0.0241096 0.0232918 4.257120e-02 0.0027403 6.613610e-01 Htr2c up
108 SLC35F4 SLC35F4 6.9660928 3.4145385 2.040127 0.0413377 0.1207829 0.0413377 0.0234941 1.060073e+03 1.3148471 8.546653e+05 Slc35f4 up
39 FAM111A FAM111A 0.4931808 0.2189509 2.252472 0.0242925 0.0261799 0.0242925 0.0238429 1.637517e+00 1.0661403 2.515110e+00 Fam111a down
118 SYT17 SYT17 -0.6691720 0.2974328 -2.249826 0.0244600 0.0230309 0.0244600 0.0240354 5.121324e-01 0.2858953 9.173975e-01 Syt17 up
95 PROK2 PROK2 1.8148931 0.8212733 2.209853 0.0271154 0.0412250 0.0271154 0.0258169 6.140420e+00 1.2278037 3.070911e+01 Prok2 up
136 ZNF519 ZNF519 0.7099944 0.3196717 2.221011 0.0263502 0.0282681 0.0263502 0.0258965 2.033980e+00 1.0870303 3.805850e+00 Zfp941 up
92 PPIL6 PPIL6 -0.8190445 0.3663250 -2.235841 0.0253622 0.0228182 0.0253622 0.0262949 4.408527e-01 0.2150191 9.038782e-01 Ppil6 up
67 MEIG1 MEIG1 -1.4153405 0.6416480 -2.205790 0.0273987 0.0165410 0.0273987 0.0263250 2.428429e-01 0.0690484 8.540773e-01 Meig1 up
41 FRY FRY -0.6736747 0.3074954 -2.190845 0.0284630 0.0283663 0.0284630 0.0281425 5.098316e-01 0.2790527 9.314667e-01 Fry up
24 CHST15 CHST15 -0.4167445 0.1902333 -2.190702 0.0284734 0.0278526 0.0284734 0.0281733 6.591893e-01 0.4540287 9.570553e-01 Chst15 up
19 CDH7 CDH7 -0.6616486 0.3054743 -2.165971 0.0303134 0.0216067 0.0303134 0.0286263 5.160000e-01 0.2835499 9.390093e-01 Cdh7 up
57 KNDC1 KNDC1 -0.2969632 0.1366881 -2.172560 0.0298134 0.0279141 0.0298134 0.0293196 7.430714e-01 0.5684358 9.713588e-01 Kndc1 up
125 TTC34 TTC34 -3.7733836 1.7457180 -2.161508 0.0306561 0.0235946 0.0306561 0.0297951 2.297420e-02 0.0007504 7.033933e-01 Ttc34 up
49 HHATL HHATL 0.2470745 0.1144943 2.157963 0.0309307 0.0303280 0.0309307 0.0308650 1.280274e+00 1.0229287 1.602363e+00 Hhatl up
53 KCNB1 KCNB1 -0.4829054 0.2251743 -2.144585 0.0319861 0.0281475 0.0319861 0.0316609 6.169882e-01 0.3968333 9.592804e-01 Kcnb1 up
51 HS6ST2 HS6ST2 0.8537621 0.4008883 2.129676 0.0331984 0.0357143 0.0331984 0.0317125 2.348466e+00 1.0704032 5.152535e+00 Hs6st2 up
126 TTLL11 TTLL11 1.3664702 0.6377193 2.142745 0.0321335 0.0412975 0.0321335 0.0321406 3.921484e+00 1.1236286 1.368605e+01 Ttll11 up
72 NLRP6 NLRP6 0.5442128 0.2548265 2.135621 0.0327103 0.0448962 0.0327103 0.0322133 1.723251e+00 1.0457789 2.839601e+00 Nlrp6 up
64 LUZP2 LUZP2 -0.3671389 0.1727341 -2.125457 0.0335485 0.0367364 0.0335485 0.0323780 6.927134e-01 0.4937670 9.718185e-01 Luzp2 up
10 BRINP1 BRINP1 -0.3392242 0.1600891 -2.118972 0.0340928 0.0305033 0.0340928 0.0324119 7.123227e-01 0.5204856 9.748658e-01 Brinp1 up
56 KLHDC9 KLHDC9 -0.2353128 0.1106619 -2.126413 0.0334689 0.0371299 0.0334689 0.0330566 7.903236e-01 0.6362230 9.817491e-01 Klhdc9 up
88 PLCB1 PLCB1 -0.6420079 0.3024846 -2.122448 0.0338001 0.0324093 0.0338001 0.0333069 5.262348e-01 0.2908735 9.520392e-01 Plcb1 up
105 SIDT1 SIDT1 -0.4174642 0.1983770 -2.104398 0.0353437 0.0278401 0.0353437 0.0339631 6.587150e-01 0.4465178 9.717541e-01 Sidt1 up
107 SLC1A2 SLC1A2 -0.2124443 0.1003561 -2.116904 0.0342680 0.0375824 0.0342680 0.0340428 8.086053e-01 0.6642221 9.843735e-01 Slc1a2 up
38 EMID1 EMID1 -0.4502308 0.2133506 -2.110287 0.0348337 0.0338802 0.0348337 0.0343860 6.374810e-01 0.4196265 9.684374e-01 Emid1 up
13 CACNA2D4 CACNA2D4 1.0245697 0.4891258 2.094696 0.0361980 0.0427101 0.0361980 0.0350024 2.785896e+00 1.0681207 7.266237e+00 Cacna2d4 up
76 NXPH3 NXPH3 -0.3774392 0.1806948 -2.088822 0.0367238 0.0409742 0.0367238 0.0363733 6.856149e-01 0.4811412 9.769850e-01 Nxph3 up
129 UNC13B UNC13B -0.7827685 0.3736143 -2.095125 0.0361599 0.0336327 0.0361599 0.0369294 4.571387e-01 0.2197996 9.507559e-01 Unc13b up
132 WNT9A WNT9A 0.6958626 0.3367280 2.066542 0.0387773 0.0463104 0.0387773 0.0378423 2.005438e+00 1.0365397 3.880008e+00 Wnt9a up
112 SMIM1 SMIM1 0.5206950 0.2527491 2.060126 0.0393865 0.0428917 0.0393865 0.0385225 1.683197e+00 1.0256390 2.762329e+00 Smim1 up
9 BAIAP3 BAIAP3 -0.2794113 0.1351514 -2.067396 0.0386969 0.0418946 0.0386969 0.0390339 7.562288e-01 0.5802460 9.855853e-01 Baiap3 up
33 DMKN DMKN -0.3291229 0.1606125 -2.049173 0.0404452 0.0368210 0.0404452 0.0393216 7.195546e-01 0.5252307 9.857741e-01 Dmkn up
115 SPRY3 SPRY3 0.4960903 0.2418322 2.051382 0.0402298 0.0386226 0.0402298 0.0404007 1.642288e+00 1.0223540 2.638136e+00 Spry3 up
2 ABHD3 ABHD3 0.5955091 0.2929307 2.032935 0.0420591 0.0407117 0.0420591 0.0409840 1.813954e+00 1.0216055 3.220842e+00 Abhd3 up
18 CD5L CD5L 0.7754014 0.3848963 2.014572 0.0439495 0.1129359 0.0439495 0.0414056 2.171464e+00 1.0212410 4.617181e+00 Cd5l down
58 LGI3 LGI3 0.1822722 0.0897599 2.030665 0.0422890 0.0443037 0.0422890 0.0414997 1.199941e+00 1.0063663 1.430749e+00 Lgi3 up
99 RSPO3 RSPO3 -0.6746499 0.3363098 -2.006037 0.0448523 0.0301619 0.0448523 0.0427121 5.093347e-01 0.2634728 9.846247e-01 Rspo3 up
32 DCHS2 DCHS2 -1.0486217 0.5210343 -2.012577 0.0441591 0.0349509 0.0441591 0.0427312 3.504204e-01 0.1262072 9.729591e-01 Dchs2 up
35 DNAH12 DNAH12 3.9025793 1.9420087 2.009558 0.0444780 0.0681526 0.0444780 0.0436603 4.953004e+01 1.1011029 2.227971e+03 Dnah12 up
31 CYB561 CYB561 -0.3508557 0.1754585 -1.999651 0.0455380 0.0350770 0.0455380 0.0445372 7.040854e-01 0.4992003 9.930608e-01 Cyb561 up
48 GPR176 GPR176 0.3455603 0.1729604 1.997916 0.0457257 0.0478815 0.0457257 0.0446132 1.412781e+00 1.0065858 1.982892e+00 Gpr176 up
34 DMRTC1 DMRTC1 98.5643120 49.8616264 1.976757 0.0480691 0.0630351 0.0480691 0.0448591 6.396418e+42 2.3101676 1.771047e+85 Dmrtc1a up
116 SPTBN5 SPTBN5 0.6025659 0.3021065 1.994548 0.0460922 0.0585582 0.0460922 0.0449381 1.826800e+00 1.0105029 3.302513e+00 Sptbn5 up
8 ARPP21 ARPP21 -0.3743726 0.1867061 -2.005144 0.0449477 0.0462126 0.0449477 0.0451881 6.877206e-01 0.4769661 9.916001e-01 Arpp21 up
7 ALDOC ALDOC -0.2765491 0.1381129 -2.002341 0.0452480 0.0542366 0.0452480 0.0455496 7.583964e-01 0.5785413 9.941643e-01 Aldoc up
23 CHST1 CHST1 -0.2144981 0.1081277 -1.983748 0.0472839 0.0521806 0.0472839 0.0467366 8.069463e-01 0.6528391 9.974316e-01 Chst1 up
131 WNT4 WNT4 -0.7042827 0.3598625 -1.957089 0.0503371 0.0247391 0.0503371 0.0469690 4.944631e-01 0.2442409 1.001035e+00 Wnt4 up
20 CDK6 CDK6 0.3824756 0.1938366 1.973185 0.0484744 0.0528413 0.0484744 0.0485995 1.465909e+00 1.0025661 2.143389e+00 Cdk6 down
97 RASGRF1 RASGRF1 -0.2693178 0.1370775 -1.964712 0.0494476 0.0439386 0.0494476 0.0487218 7.639004e-01 0.5839238 9.993493e-01 Rasgrf1 up
4 ADAMTS3 ADAMTS3 1.9769091 0.9586936 2.062086 0.0391995 0.0865033 0.0391995 0.0488657 7.220391e+00 1.1028571 4.727180e+01 Adamts3 up
119 SYT3 SYT3 -0.3410561 0.1739619 -1.960522 0.0499348 0.0391895 0.0499348 0.0489593 7.110190e-01 0.5055971 9.999029e-01 Syt3 up
81 PCDHGA4 PCDHGA4 1.0331251 0.5206786 1.984190 0.0472347 0.0638059 0.0472347 0.0497464 2.809833e+00 1.0126938 7.796199e+00 Pcdhga4 up
63 LSAMP LSAMP -0.6089189 0.3110885 -1.957382 0.0503026 0.0520013 0.0503026 0.0499826 5.439386e-01 0.2956316 1.000804e+00 Lsamp up